DRSC/TRiP Functional Genomics Resources

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Protein Alignment WDR62 and Wdr62

DIOPT Version :10

Sequence 1:NP_001077430.1 Gene:WDR62 / 284403 HGNCID:24502 Length:1523 Species:Homo sapiens
Sequence 2:NP_001259886.1 Gene:Wdr62 / 33367 FlyBaseID:FBgn0031374 Length:2397 Species:Drosophila melanogaster


Alignment Length:1524 Identity:511/1524 - (33%)
Similarity:750/1524 - (49%) Gaps:339/1524 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    20 SVMAGVP----------ARRGQSSPPPAPPICLRRRTRLSTASEETV------------QNRVSL 62
            |:.|..|          |.:.||..|.|.|:         |.|..:|            ..::.|
  Fly     5 SLSASTPTLSTLHHQRMALQSQSQSPLASPL---------TPSPSSVFGSPKFPANYERSEKIKL 60

Human    63 EKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIV 127
            :||||:|..:::.|...|.:|.:||.|||.||:.:.|...|.::.||:||:.:::|||..|:|:.
  Fly    61 KKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVA 125

Human   128 TGENGHRPAVRIWDVEEKN----------QVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLN 182
            |||.|..||:::|::|..|          .|||.:.|||.|.||||||..|::||:|.||||::|
  Fly   126 TGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVN 190

Human   183 VWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGIL 247
            |:||:.::.:||||:|.:|.|:.||||.|||||||||||::|:||...:.|  ..:||:|||.||
  Fly   191 VFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYK--DPIPLMGRSAIL 253

Human   248 GELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGC 312
            |:|.:|.||.||||:|..|.||:.::..|.|.:|:.:|:|:||:..:.:.::|:||::..|..||
  Fly   254 GDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGC 318

Human   313 TDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCV 377
            .:.|:|||.:.:|.|:..||:.||||||||||::.:.:.....:|.:||.:|:.||.....:|||
  Fly   319 AESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCV 383

Human   378 YKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYP---EFEDQRACLPSGSFLTCSSDNTIRF 439
            |.|||:||||::||:||||..|.|:||:.:|.||..|   |.|..:. ||...|:|||||:|||.
  Fly   384 YNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQT-LPEECFVTCSSDDTIRV 447

Human   440 WNLDSSPDSH-WQKNIFSNTLLKVVYVENDIQHLQDM--SHFPDRGSENGTPMDVKAGVRVMQVS 501
            |.||...::. :::||:|..|||:||.::::|.::|.  |.|...|:.:   .|.:.|||.:::|
  Fly   448 WGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSS---YDGRNGVRCIKIS 509

Human   502 PDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNV 566
            |:.||||||||.||:|::.|..:..|..:|||::||||||||..:....|||||||||||||.:|
  Fly   510 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDV 574

Human   567 EKNYNLEQTLDDHSSSITAIKFAG-NRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTT 630
            .:||.|.|||||||||||:|||.| ..:.|||||||||||.|||.|    |..|:|..:.:.|||
  Fly   575 AQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTT 635

Human   631 LYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDK 695
            ||||::|...|::..||||||||||.|.|.||.|.:|||..|||||:|:.:||||.::||||:||
  Fly   636 LYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDK 700

Human   696 SISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEID 760
            :::|.|:||.||:|:|:||||::|.:|||.||.|||:.|||.|:|||.:..::       ::.:.
  Fly   701 TLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDM-------IVTMQ 758

Human   761 HRQQQQHTNDKKRSGH---PRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDP 822
            .|..||    :.||||   ||....:|.|..|...||..:.|   :.:.:|:..:.....|.   
  Fly   759 ARMSQQ----RLRSGHAPLPRPLAPISPPDGIVLESPTSEIE---QPQLQPKFGVAERFSDV--- 813

Human   823 DPRCLLTNGKLPLWAKRLLGDDDVADGLA-------------FHAKRSY---------------- 858
                    |:||.||.|....|..:..|:             .||..|.                
  Fly   814 --------GQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAP 870

Human   859 QPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESP----QE 919
            :..||||:|:.|      |:..|                           .|.|.||||    ..
  Fly   871 RARGRWAQRSTQ------LETAD---------------------------DLRSNSESPLGTVSS 902

Human   920 AGRGHPSFLPQQKE-SSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGD---------- 973
            .| ||.....|..: :|.:|:.|.|:    .|....||     .:::|...::|:          
  Fly   903 VG-GHSGVNVQTSDYNSASSKDITYN----QTYLSEDS-----SIDSGMETRRGELKFIGSSNNG 957

Human   974 SYLRVSS-----DSPKDQSPPEDSGESEADLECSFAAIHSPAPPPD----PAPRFATSLPHFPGC 1029
            :.:.|||     .|..:.:....||.::..|:.           ||    |..||.|   |....
  Fly   958 TVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQL-----------PDKRLKPGLRFDT---HTHDH 1008

Human  1030 AGPTEDELSLPEGPSVPS-------SSLPQTPEQEKFLRHHFETLTESPCRELF--------PAA 1079
            .|..||   :.:|....|       :..|.||...|....:.:.|.:|..|:.|        |:|
  Fly  1009 DGDVED---ISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSA 1070

Human  1080 LG----------DVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKS--PE-- 1130
            |.          ....|:.||....|....:.:.|:|....|  :...|..:|...:.:  ||  
  Fly  1071 LSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGS--SENLPQSSTNSFLHAALPEGP 1133

Human  1131 --VKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLP---- 1189
              ...|:||||..|:.:...:.:....:||             ||.:|...:......:|.    
  Fly  1134 GLTTPMERGGSSRRSISAKHNTENGKSVAA-------------PPTITKSYTSTKKEELLQVINK 1185

Human  1190 --------TDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEG----PIV 1242
                    |.:|..|..:|    :|:..|.|...|:..:..|..|.:..|.:.|...|    |:.
  Fly  1186 VKQQLENGTRKNGNTRLNA----IAEVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPVD 1246

Human  1243 ATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDG 1307
            :........|.:              ||||....:::.|                          
  Fly  1247 SHDTSQYTSPQN--------------TTATAAPTNTQQQ-------------------------- 1271

Human  1308 LLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRP------SLPAPES------------- 1353
             :||||..|         :..|....:.|.:.|.....|      :..||:|             
  Fly  1272 -IQPPVQQQ---------YQIPKEPHQQAQQQHQQYAPPASQQFFNCAAPKSKLQQNFQTMRQVQ 1326

Human  1354 ---PGLPAHPSNPQLPEARPGIP-GGTAS 1378
               |..|.|....|: ...||:| ||:|:
  Fly  1327 QHYPPYPHHVGVHQI-HPPPGVPFGGSAA 1354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR62NP_001077430.1 WD40 42..567 CDD:441893 244/552 (44%)
WD 1 109..150 18/50 (36%)
WD40 repeat 114..153 CDD:293791 17/48 (35%)
WD 2 153..194 22/40 (55%)
WD40 repeat 159..197 CDD:293791 21/37 (57%)
WD 3 196..234 22/37 (59%)
WD40 repeat 201..239 CDD:293791 21/37 (57%)
WD40 repeat 270..332 CDD:293791 19/61 (31%)
WD 4 291..330 12/38 (32%)
WD40 repeat 350..399 CDD:293791 23/48 (48%)
WD 5 357..396 21/38 (55%)
WD40 <364..744 CDD:441893 208/386 (54%)
WD 6 402..450 22/51 (43%)
WD40 repeat 407..442 CDD:293791 18/37 (49%)
WD 7 490..529 19/38 (50%)
WD40 repeat 498..532 CDD:293791 15/33 (45%)
WD 8 532..574 27/41 (66%)
WD40 repeat 538..578 CDD:293791 26/39 (67%)
WD 9 578..618 27/40 (68%)
WD40 repeat 583..620 CDD:293791 22/37 (59%)
WD 10 626..665 23/38 (61%)
WD40 repeat 632..667 CDD:293791 20/34 (59%)
WD 11 671..713 24/41 (59%)
WD40 repeat 676..712 CDD:293791 19/35 (54%)
WD 12 714..752 19/37 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..824 17/64 (27%)
WD 13 803..846 9/42 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 908..935 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..1055 23/118 (19%)
WD 14 1137..1178 9/40 (23%)
PHA03247 <1170..1413 CDD:223021 46/248 (19%)
WD 15 1260..1298 5/37 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1382 14/58 (24%)
Wdr62NP_001259886.1 WD40 <73..236 CDD:441893 79/162 (49%)
WD40 repeat 73..107 CDD:293791 12/33 (36%)
WD40 repeat 113..161 CDD:293791 17/47 (36%)
WD40 156..573 CDD:475233 205/422 (49%)
WD40 repeat 167..207 CDD:293791 22/39 (56%)
WD40 repeat 209..285 CDD:293791 42/77 (55%)
WD40 repeat 303..338 CDD:293791 12/34 (35%)
WD40 repeat 353..407 CDD:293791 24/53 (45%)
WD40 <437..750 CDD:441893 175/319 (55%)
WD40 repeat 505..540 CDD:293791 15/34 (44%)
WD40 repeat 546..586 CDD:293791 26/39 (67%)
WD40 repeat 591..631 CDD:293791 24/43 (56%)
WD40 repeat 637..672 CDD:293791 20/34 (59%)
WD40 repeat 679..717 CDD:293791 21/37 (57%)
WD40 repeat 723..749 CDD:293791 16/25 (64%)

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