DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPR21 and CG13579

DIOPT Version :9

Sequence 1:	NP_005285.1	Gene:	GPR21 / 2844	HGNCID:	4476	Length:	349	Species:	Homo sapiens
Sequence 2:	NP_001261169.1	Gene:	CG13579 / 37905	FlyBaseID:	FBgn0035010	Length:	716	Species:	Drosophila melanogaster

Alignment Length:	448	Identity:	93/448 - (20%)
Similarity:	149/448 - (33%)	Gaps:	147/448 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    10 SSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVF----HCAPLLNHHTTSYFIQT 70
            |.|.| :...|..||:     |.::|:.||:.:|..|.:||||.    :.|.:  |....|.:.:
  Fly    25 SGHNF-IAHIGIAETI-----EAVLILVLTLGVIGANCLVIFVINNRRYAAYI--HQQPRYLLTS 81

Human    71 MAYADLFVGVSCVVP--SLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASLACISIDRYIAITK 133
            :|..||.:|: .:.|  .:..|.|..|..| :.|||...:...|...|...|.|:::|||:....
  Fly    82 LALNDLTIGL-LITPFGLMPALFHCWPYGE-IFCQIQALLRGALSQQSAVILVCMAVDRYMCALH 144

Human   134 PLTYNTLVTPWRLRLCIFLIWLYSTLVF----LPSFFHWGKPGYHGDVFQWCAESWHTDSYFTLF 194
            |..|....:.......:.|.|:.|..||    ||..:::...|.      ...|.:::...:.:.
  Fly   145 PRRYYQHSSKKGCVAILSLTWIISLTVFGFLVLPKGYYFNNTGL------MACEPFYSKPSYRIL 203

Human   195 IVMMLYAPAALIVCFTYFNIFRIC-----------------------------------QQH--- 221
            ....||.|..:::.:.|.:.|.:.                                   |||
  Fly   204 STCALYFPTTMVLMYCYGSSFHMSRFRLNDPTMPLTAAAHHPHPHPHPTAAQQLQMHQHQQHHQQ 268

Human   222 -----------------------------------------------------------TKDISE 227
                                                                       ||.|..
  Fly   269 AGMHSHLYHGHSHHPSHPSHPNHPNHHGHPHHHGPPVMGHLSMAMSMGLAGMPNMTNKITKKIVP 333

Human   228 RQARFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS-NRFASFLTTW 291
            .|.:  :.||.|....|.           |:..|.::..|:.|..::.:.||.. ..|..||.||
  Fly   334 IQEK--NSSGSTSRSMAA-----------ISLGFIVMVTPWTIQEIVTACTGSKLPPFLDFLVTW 385

Human   292 LAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI 349
            .|:|||..|..:|.|.||.|:|..::|....|.          |:....:.....|||
  Fly   386 TALSNSLWNPFMYWLLNSDFRRMSRQLMPNKCF----------PHEDTPEHKSGCCHI 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR21	NP_005285.1	7tm_classA_rhodopsin-like	31..308	CDD:320086	77/384 (20%)
		TM helix 1	31..56	CDD:320086	10/28 (36%)
		TM helix 2	64..90	CDD:320086	6/27 (22%)
		TM helix 3	102..132	CDD:320086	10/29 (34%)
		TM helix 4	145..164	CDD:320086	6/22 (27%)
		TM helix 5	188..213	CDD:320086	4/24 (17%)
		TM helix 6	238..275	CDD:320086	6/36 (17%)
		TM helix 7	283..308	CDD:320086	12/24 (50%)
CG13579	NP_001261169.1	7tm_4	51..>148	CDD:304433	29/100 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910