Protein Alignment SLC13A5 and Indy

DIOPT Version :10

• Sequence 1: NP_808218.1
• Gene: SLC13A5 / 284111
• HGNCID: 23089
• Length: 568
• Species: Homo sapiens
• Sequence 2: NP_730363.2
• Gene: Indy / 40049
• FlyBaseID: FBgn0036816
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 577
• Identity: 217/577 - (37%)
• Similarity: 337/577 - (58%)
• Gaps: 54/577 - (9%)

Human     7 YVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQ 71
            :.:.:|..|: |:.|||.||:::|......||.|::::|||:|.||.:||.|||::|::.||:..
  Fly    37 FANHWKGLVV-FLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMG 100

Human    72 ILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLS 136
            |:.|.|.|..|.|||.::|:||::||:|||..|||||:|||.:..||..|.||..|.:.||..||
  Fly   101 IMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLS 165

Human   137 MWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQER 201
            |||||.|.||||.||::|:|::::|....           |....|..|::  |......||:
  Fly   166 MWISNAACTAMMCPIIQAVLEELQAQGVC-----------KINHEPQYQIV--GGNKKNNEDE-- 215

Human   202 KRLCKAMTLC----ICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNML 262
            ......:|||    |.||:|:||..|:.||..|:...|.....|.:|.:.::|.::..::.|:||
  Fly   216 PPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSML 280

Human   263 VMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKA------------ALKVLQEEYRKLGPLSFA 315
            |..|..:::||:.:|          ||...|:::|            |.||:.:.|:.|||:|..
  Fly   281 VYTLLTFVFLQWHFM----------GLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIH 335

Human   316 EINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNF- 379
            ||.|:|.|..:|:::|:|.||...||..:.    .:|.:.::...|||..:.|::|:   .:.|
  Fly   336 EIQVMILFIFMVVMYFTRKPGIFLGWADLL----NSKDIRNSMPTIFVVVMCFMLPA---NYAFL 393

Human   380 RSQTEEERKTPFYP-PPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAV 443
            |..|......|..| |.|:.||..|.|||||:|.|||||||||:||:.||::..:|..:..|..:
  Fly   394 RYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVL 458

Human   444 PPAAITLILSLLVAVF-TECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVA 507
            |.:.:.|:: :||||| |..:||||...:.:|:.|.||.:|.::|||::||..|:.|.||.|||:
  Fly   459 PNSVLLLVV-ILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVS 522

Human   508 TPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIF-DLDHFPDWANV 563
            |||||:|..|.:::..||...|:...||.:..:|:...|||..:: :|:.||:||.:
  Fly   523 TPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQI 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC13A5	NP_808218.1	CitMHS	<11..164	CDD:460985	75/152 (49%)
		CitT	91..547	CDD:440239	174/474 (37%)
Indy	NP_730363.2	CitT	120..545	CDD:440239	170/457 (37%)