Protein Alignment SLC13A5 and Indy-2

DIOPT Version :10

• Sequence 1: NP_808218.1
• Gene: SLC13A5 / 284111
• HGNCID: 23089
• Length: 568
• Species: Homo sapiens
• Sequence 2: NP_001027201.1
• Gene: Indy-2 / 3772456
• FlyBaseID: FBgn0260466
• Length: 562
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 201/564 - (35%)
• Similarity: 300/564 - (53%)
• Gaps: 44/564 - (7%)

Human    19 VTPLLLLPLVI----LMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVC 79
            :.||:.||::|    ...|:| :|.::|:.||:.|.||.:|:.||:|.|::..||..::::..||
  Fly    27 IIPLITLPILIYGFQTDMAEF-KCLWLIVTMALLWITETLPIYVTALFPLVFCPLLGLVNASIVC 90

Human    80 VQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTAT 144
            .||..||.::||||||||:.:|..|||.|||||.:..||..|.||.:|.|.|:..:.:||||:|.
  Fly    91 KQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLMSVSTFMGLWISNSAG 155

Human   145 TAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCKAMT 209
            ||||.|||:|::.:::..                |..|......|.| :.:.|.....::..|..
  Fly   156 TAMMCPIVKALVNELDTN----------------KIFPVYMTQEEEP-VEEGEPPHPSKITVAFY 203

Human   210 LCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLV----MLLFAWL 270
            ..|.||:||||..||.|||.|:|..|...|.||.|...:.||::..::.|.|::    :::.|:|
  Fly   204 AGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIPLMVIVNVTLVIIAFL 268

Human   271 WLQFVYMRFNFKKSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDP 335
            .......|.| .|:.....|:..|.|....||::.:..|||:|..||.:.|.|..:::|..:|.|
  Fly   269 ITHMGLFRPN-SKTGKIIAEANTNRKLMEDVLRQRHIDLGPMSCHEIQMAIAFAFMIVLLITRKP 332

Human   336 GFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNFRSQTEEERKTPFYP---PPLL 397
            ||:|||..:.    ..|.|..|:...|:..|:|.:|:|...|.:..     .|.||..   ..:|
  Fly   333 GFVPGWSDLI----NRKVVGSASGLSFIVLLIFALPTQYTFFKYCC-----GKGPFTAQAIDAIL 388

Human   398 DWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTEC 462
            .|:.....:|||::.|||||||||..|..:||::.:.|.|:.|..:|...:..|..:|...|:..
  Fly   389 SWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQSITFVLANFFSAF 453

Human   463 TSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVK 527
            .:||....:.|||...||.::.|:||.:.||..|..|..:.|||:|||||||..|.|:|......
  Fly   454 NANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHIKTKYFAC 518

Human   528 TGVIMNIIGVFCVFLAVNTWGRAIF-DLDHFPDWA----NVTHI 566
            .|::..|||:....:..||||..|| :...|||||    |.|.|
  Fly   519 CGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAKEIKNQTKI 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC13A5	NP_808218.1	CitMHS	<11..164	CDD:460985	65/148 (44%)
		CitT	91..547	CDD:440239	160/462 (35%)
Indy-2	NP_001027201.1	CitT	102..544	CDD:440239	164/468 (35%)