Protein Alignment SLC13A5 and slc13a5

DIOPT Version :10

• Sequence 1: NP_808218.1
• Gene: SLC13A5 / 284111
• HGNCID: 23089
• Length: 568
• Species: Homo sapiens
• Sequence 2: XP_004911787.1
• Gene: slc13a5 / 100490590
• XenbaseID: XB-GENE-983513
• Length: 603
• Species: Xenopus tropicalis
• Alignment Length: 596
• Identity: 370/596 - (62%)
• Similarity: 452/596 - (75%)
• Gaps: 42/596 - (7%)

Human     1 MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVL 65
            ||..:.::...|.|:|||:||||||||.:|:..|...|||.|||||:||||||||||||:|:|||
 Frog    17 MAPCMKWLLNCKRFLILFITPLLLLPLPLLIKTKEASCAYCIILMAVYWCTEVIPLAVTALLPVL 81

Human    66 LFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMG 130
            |||:|.||:|::||:||:|||||||:||||||||||.|||||||||:.||.||.:||.|||||||
 Frog    82 LFPMFGILESKKVCMQYLKDTNMLFVGGLIVAVAVEHWNLHKRIALKVLLIVGVRPALLMLGFMG 146

Human   131 VTALLSMWISNTATTAMMVPIVEAILQQ----------MEATSAATEAGLEL------------- 172
            |||.||||||||||||||||||:|:|.|          :|:....|...|||
 Frog   147 VTAFLSMWISNTATTAMMVPIVQAVLSQLNTAGEDPSMLESLEGQTNPALELETKNAIPLEPVQI 211

Human   173 VDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQM 237
            |..|...|:|.     |.|     |..||||:.|.|.||:||||||||||||||||||:||.||.
 Frog   212 VSNGHVAEIPE-----EAP-----EKDERKRISKGMMLCVCYAASIGGTATLTGTGPNLVLKGQF 266

Human   238 NELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALKVL 302
            .::||::.|::||||||.||||||.|||..:|.||||.::.|||||:||||..:.:.|:||..|:
 Frog   267 TQIFPNNGDILNFASWFGFAFPNMAVMLCMSWFWLQFSFIGFNFKKTWGCGATTSEKERAAYNVI 331

Human   303 QEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLL 367
            :||||||||:|:||.:||..|.|||:|||:|||||:.||.|:.:.:...:||:|||||:|||.||
 Frog   332 REEYRKLGPISYAESSVLFLFILLVLLWFTRDPGFVIGWATILFNKDNIEYVTDATVAVFVAFLL 396

Human   368 FIVPSQKPK---------FNFRSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKG 423
            ||:|:.:||         |:.....:.|.|..|:..|||.|||..:::||.||||||||||||||
 Frog   397 FILPASRPKISCCKARKSFDLEEFEQAEEKDTFFSAPLLTWKVVHKQMPWSIVLLLGGGFALAKG 461

Human   424 SEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPL 488
            |:|||||.|:|:||.|||.:||.||.:||||::||||||.|||||.||||||.|||:||||:|||
 Frog   462 SDASGLSHWLGQQMAPLHTIPPWAIAIILSLMIAVFTECASNVATATLFLPILASMTRSIGVNPL 526

Human   489 YIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFD 553
            |||:|||||.|||||||||||||||||:||||:|:||||||::|||||:.|..||:|||||.:|.
 Frog   527 YIMIPCTLSTSFAFMLPVATPPNAIVFSYGHLRVSDMVKTGIVMNIIGIICTTLAINTWGRPMFS 591

Human   554 LDHFPDWANVT 564
            ||.||.|||:|
 Frog   592 LDTFPQWANIT 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC13A5	NP_808218.1	CitMHS	<11..164	CDD:460985	114/162 (70%)
		CitT	91..547	CDD:440239	298/487 (61%)
slc13a5	XP_004911787.1	ArsB_NhaD_permease	50..592	CDD:473875	346/551 (63%)