DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEK8 and fin1

DIOPT Version :9

Sequence 1:	NP_835464.1	Gene:	NEK8 / 284086	HGNCID:	13387	Length:	692	Species:	Homo sapiens
Sequence 2:	NP_593305.1	Gene:	fin1 / 2542237	PomBaseID:	SPAC19E9.02	Length:	722	Species:	Schizosaccharomyces pombe

Alignment Length:	290	Identity:	100/290 - (34%)
Similarity:	151/290 - (52%)	Gaps:	29/290 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIE 65
            ||||:.:..:|.|:||.::...|..|..|:..|:|....:|::|:|...:|..:|:.|.|||:::
pombe     1 MEKYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQYIADEVNILRNLKHPNIVQ 65

Human    66 YYENFLEDKALMI--AMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALHHVH------ 120
            |....|...|.:|  .|||...|.||..||  |.......|:.:|.||.|:||||:..|
pombe    66 YCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRCHYGENAP 130

Human   121 -------------THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYT--VVGTPCYI 170
                         ...:||||:|..||.||::.. ||:||||:||:|.: ::.:|  .||||.|:
pombe   131 ACDSQWPREIFHPKQSVLHRDIKPANIFLDENNS-VKLGDFGLSKLLDN-TRVFTQSYVGTPYYM 193

Human   171 SPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLV 235
            |||:....||:.|||:||||||::|:..|...||..:...|...|..|..:.....||.::..|:
pombe   194 SPEIIRSSPYSAKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQGNLSCWDHHYSDDVFLLI 258

Human   236 LSLLSLEPAQRPPLSHIMAQPLC--IRALL 263
            ...|.:....||....::..|:.  ||:.|
pombe   259 RHCLEVNSDLRPTTYQLLRSPILSDIRSKL 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEK8	NP_835464.1	STKc_Nek8	3..258	CDD:270859	95/279 (34%)
		RCC1	276..657	CDD:332518
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..301
		RCC1 1	312..350
		RCC1 2	410..461
		RCC1 3	462..513
		RCC1 4	580..631
		RCC1 5	632..684
fin1	NP_593305.1	STKc_Nek2	3..281	CDD:270857	95/279 (34%)
fin1	NP_593305.1	S_TKc	4..281	CDD:214567	94/278 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940