DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR17 and gpr17

DIOPT Version :9

Sequence 1:	NP_001154887.1	Gene:	GPR17 / 2840	HGNCID:	4471	Length:	367	Species:	Homo sapiens
Sequence 2:	XP_004917917.1	Gene:	gpr17 / 100491781	XenbaseID:	XB-GENE-1012430	Length:	337	Species:	Xenopus tropicalis

Alignment Length:	353	Identity:	179/353 - (50%)
Similarity:	238/353 - (67%)	Gaps:	30/353 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    28 SMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGT 92
            |:.|.|:|.|  :...||...:.|.:||.|||.|.:..|.|..::..:||.|||.|||:|.:..:
Frog     2 SVMGAELALP--VNATSLVWVDTCVRETSLENALLSLCYFLGLLVGGLGNILALSLFIQDRQQRS 64

Human    93 PANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADR 157
            |:::||:|||::||..:|.|||||.||.|.|.||||.:.|||:.|:||||||||:|||..||.||
Frog    65 PSDIFLLHLAISDLFLLLSLPTRLFYHLSSNSWPFGALPCRLSAFVFYLNMYASLYFLAGISIDR 129

Human   158 FLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTV---VCLQLYREKASH 219
            :||||||:.|:|:||||:||:.|.||||:||.|.||||:.     ..|..   .|..||||..|.
Frog   130 YLAIVHPLNSVKIRRPLHAHVTCGFLWVIVAFATAPLLIG-----NGHATDDRACRLLYRETPSL 189

Human   220 HALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRS 284
            .||.||:.||..||:.|||||.||::.||.|  .:::.|.:||:|:.:||.|||:||||||::|:
Frog   190 RALSSLSAAFAIPFLGTVTCYGLILKRLRNG--GDRKPKERAVKMVLLVLTIFLICFVPYHLSRA 252

Human   285 VYVLHYRSHG-------ASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHAL-CNLLC 341
            :|  |....|       :||:.::.||||||.||||::||.||||::|||..:|||.|| |
Frog   253 LY--HVLMPGGEAQAPMSSCSLRQGLALANRFTSCLSTLNAALDPLVYFFAVKKFREALPC---- 311

Human   342 GKRLKGPPP--SFEGKTNESSLSAKSEL 367
              |.|||..  |.||||.:||||||:|:
Frog   312 --RNKGPDAARSREGKTEDSSLSAKTEV 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR17	NP_001154887.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		179/353 (51%)
GPR17	NP_001154887.1	7tm_1	76..325	CDD:278431	138/258 (53%)
gpr17	XP_004917917.1	7tm_GPCRs	32..309	CDD:391938	147/285 (52%)
		TM helix 1	34..58	CDD:341315	9/23 (39%)
		TM helix 2	67..88	CDD:341315	11/20 (55%)
		TM helix 3	105..127	CDD:341315	15/21 (71%)
		TM helix 4	150..166	CDD:341315	9/15 (60%)
		TM helix 5	188..211	CDD:341315	13/22 (59%)
		TM helix 6	227..252	CDD:341315	14/24 (58%)
		TM helix 7	277..302	CDD:341315	18/24 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	274	1.000	Domainoid score	I10537
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H83191
Inparanoid	1	1.050	325	1.000	Inparanoid score	I10236
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1166460at2759
OrthoFinder	1	1.000	-	-		FOG0007811
OrthoInspector	1	1.000	-	-		oto152804
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060