DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UTS2R and AstA-R2

DIOPT Version :9

Sequence 1:	NP_001368826.1	Gene:	UTS2R / 2837	HGNCID:	4468	Length:	389	Species:	Homo sapiens
Sequence 2:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster

Alignment Length:	317	Identity:	89/317 - (28%)
Similarity:	146/317 - (46%)	Gaps:	26/317 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    29 NATLNSSWASPTEPSSLED---LVATGT----IGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASM 86
            |.:||::.......|...|   |...||    :|.....:.:.|..||...::|...:....::.
  Fly     9 NISLNATRNEENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTT 73

Human    87 YVYVVNLALADLLY-LLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYA 150
            .:.:||||.|||:: :|.|||....|:...|.:|...||.:..|..:|..|||:||.:||.:|:.
  Fly    74 NLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFL 138

Human   151 AVLRPL-DTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLV------RRGPKSLCL----PAWG 204
            ||:.|: ..:.|.:....:..:..|::.|::::||.....:|      :.....:|.    ...|
  Fly   139 AVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLG 203

Human   205 PRAHRAYLTLLFATSIAGPGLLIGLLYAR-LARAYRRSQ--RASFKRARRPGARALRLVLGIVLL 266
            |   |.|....|.:|...|.::|..||.| :.|.:|:..  |.| |.::|...|..|||:.:|:.
  Fly   204 P---RTYQVTFFISSYLLPLMIISGLYMRMIMRLWRQGTGVRMS-KESQRGRKRVTRLVVVVVIA 264

Human   267 FWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYR 323
            |.:.:||..|..||...........|..::......|.|.:||.||.||..|:.|:|
  Fly   265 FASLWLPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFR 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UTS2R	NP_001368826.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		3/9 (33%)
		7tmA_UII-R	53..326	CDD:320130	82/290 (28%)
		TM helix 1	54..78	CDD:320130	5/23 (22%)
		TM helix 2	87..108	CDD:320130	11/21 (52%)
		TM helix 3	124..146	CDD:320130	9/21 (43%)
		TM helix 4	168..184	CDD:320130	2/15 (13%)
		TM helix 5	209..232	CDD:320130	7/22 (32%)
		TM helix 6	257..279	CDD:320130	8/21 (38%)
		TM helix 7	294..319	CDD:320130	8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..389
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	34/116 (29%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	74/261 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010