Protein Alignment SLC24A5 and CG5348

DIOPT Version :10

• Sequence 1: XP_047288350.1
• Gene: SLC24A5 / 283652
• HGNCID: 20611
• Length: 531
• Species: Homo sapiens
• Sequence 2: NP_611156.3
• Gene: CG5348 / 36877
• FlyBaseID: FBgn0034156
• Length: 625
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 122/617 - (19%)
• Similarity: 205/617 - (33%)
• Gaps: 232/617 - (37%)

Human    46 CVISPSSEFPEGFFTRQERRDGGIIIY----FLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQ 106
            |.:...::|.|..|         |.::    |.|:|.:...|::    |:.|:|:.:|..|.:::
  Fly    69 CDLKCINQFQEMIF---------IALFVAFCFQILVLLIYTINV----YYSPALKAVSRFLHMNE 120

Human   107 DVAGTTFMAAGSSAPELVTAFLGKYCSLYFLLTQCDFYFLQVNTNLAGTILHIGVFIT--KGDIG 169
            .:||.|.||.|:                    |..||:     .|||....|:.||..  ...:.
  Fly   121 HLAGVTLMAFGN--------------------TSADFF-----ANLASVERHVPVFANNLSSALF 160

Human   170 ISTILGSAIYNLLGICAACGLLSNTVST------LSCWPLFRDCAAYTISAAAVLGIIYDNQVYW 228
            :.||.|..|:.:      .....|:..|      |....|..|..|||.:..| ||       |.
  Fly   161 VITISGGLIFYI------SPFKMNSYETVRDILFLLLATLLMDYFAYTTNHFA-LG-------YE 211

Human   229 YEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQ------- 286
            ::..::||:|..|:::...|:    |:::|        ..|..|::.|.|:   ||.|
  Fly   212 FKFFIVLLVYISYIIINVADV----YLLQK--------TIASTRTKMQKLL---DEKQTPEIALK 261

Human   287 --------PFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSV-----FNM--------- 329
                    .:..:.:|.:  |..:.|..|...|....:..:.....||     .||
  Fly   262 LQDLERKLEYYSQDTRVE--ILEKSSSISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQSKN 324

Human   330 -------------------PEAD-LKRIFWVLSLPIITLLFLTTP----DCRKKFWK------NY 364
                               .:|: |.|:..::..|.:.:..|..|    :..|..|.      |.
  Fly   325 QGIFRDFFLALRPIKCQAWKQAELLNRVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINV 389

Human   365 FV-----ITFFMS-------AIW---------ISAFTYILV--------------------WMVT 388
            .|     |:.|:|       .:|         ..|.:::|.                    |:.|
  Fly   390 VVNPALSISIFLSFMHRKGNFLWYISLQNTLIYGASSFVLTVPFAVFILFHARTDVPPSYHWVFT 454

Human   389 I-----------------------TGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMA 430
            |                       .|..|.|.|..||.|:.|...::....|:..||..|...||
  Fly   455 IMNLTGSMFLIFLCATEIDTVLEVIGNILSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPKMA 519

Human   431 MSNIVGSNVFDMLCLGIPWFIKTAFINGSAPAEVNS----RGLTYITISLNISIIFLFLAVHFN- 490
            .::.:|.:.|            |..:.|:..|.|.|    |...::.....|:.|||.:|: |.
  Fly   520 FASAIGGSFF------------TIVVTGNTVAYVRSLVGNRSEHHMEEYGEIAFIFLNMAL-FTI 571

Human   491 -------GWKLDRKLGIVCL---LSYLGLATL 512
                   |:...|.:|:..:   :.||...||
  Fly   572 LLWSTTLGFFARRSMGLYSIGLYVVYLLFVTL 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC24A5	XP_047288350.1	2A1904	<20..>255	CDD:273344	50/220 (23%)
		2A1904	<321..521	CDD:273344	58/315 (18%)
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:426387	30/134 (22%)
		Na_Ca_ex	458..603	CDD:426387	33/157 (21%)