Protein Alignment SLC24A5 and CG14743

DIOPT Version :10

• Sequence 1: XP_047288350.1
• Gene: SLC24A5 / 283652
• HGNCID: 20611
• Length: 531
• Species: Homo sapiens
• Sequence 2: NP_610408.2
• Gene: CG14743 / 35860
• FlyBaseID: FBgn0033326
• Length: 611
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 102/549 - (18%)
• Similarity: 189/549 - (34%)
• Gaps: 193/549 - (35%)

Human    69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGKYCS 133
            |..:||.|:|..:      :.||.|:|:|.:..:.:::.:||...:...:|.|:|:
  Fly    82 IYCFFLCILYEGV------NSYFAPTLKIAALKMRINEYMAGVVLVGVANSTPDLL--------- 131

Human   134 LYFLLTQCDFYFLQVN---TNLAGTILHIGVFITKGDIGISTILGSAIYNLLG-ICAACGLLSNT 194
                          ||   ..:.|...:|                 |:.|.|. ||.:.|.:
  Fly   132 --------------VNLSPVRMEGLTFNI-----------------AMANALTIICLSGGAV--- 162

Human   195 VSTLSCW---------PLFRDCAAYTISAAAVLGIIYDNQVY-WYEGALLLLIYGLYVLVLCFDI 249
                 |:         .:|||.....:....|...:.|..:. |.:||:||.||.:|:|:...|:
  Fly   163 -----CFIRPFRMNGHSIFRDLLFLLLIIELVRFFMNDTALAPWIKGAILLSIYPIYLLINIVDL 222

Human   250 KINQYIIKKCSPCCACLAKAMERSEQQPL----------MGWEDEGQPF---IRRQSRTDSGIFY 301
            .:.:|.|:|.......|.::....|...:          :..:||.|..   :.|:...::|.|.
  Fly   223 ILLRYAIRKLRADIEVLRQSPSSREHDLILTEKIVRLNNLQQDDEIQILESKLYRKRTYNAGFFV 287

Human   302 EDS---GYSQLSIS-----LHGLSQVSEDPPSVFNMPE----------------ADLKRIFWVLS 342
            ...   .:.::.:.     ||.    ..:|.::|...|                ....||..:|.
  Fly   288 TPKPLIHHKEVDVETNRRILHS----KANPKNLFLFSEFLQAINPIDSEGWYLSGTCARILQILK 348

Human   343 LPIITLLFLTTP---------------DCRK------------------KFWKNYFVITFFMSAI 374
            .|:..:|.|..|               :|.:                  |:.:.|:|..|.| ||
  Fly   349 APVTLMLHLVVPLVDYQLVKHGWSKMLNCLQIVLTPFVIFALVETMLVHKYAEWYYVPQFRM-AI 412

Human   375 W-----------------------------------ISAFTYILVW----MVTITGETLEIPDTV 400
            |                                   :..|.:|..|    :::|.|...::..:.
  Fly   413 WSLLVTMPLAIVVFLHSRTDIPPFYHSSYCALTISTVIIFFWICAWEMDALISIIGVVFDLAPSY 477

Human   401 MGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDM-LCLGIPWFIKTAFINGSAPAEV 464
            |.:|..:...:..|.||...:|:.|.|.||...|:|.:|:.: :.:||...::         .::
  Fly   478 MSITFNSVSAATADLIAYAHLAKHGYGKMAFGAIIGGSVYSLAVNVGIELVLQ---------KKL 533

Human   465 NSRGLTYITISLNISI-IFLFLAVHFNGW 492
            ||||...:.....::| |||.:.:....|
  Fly   534 NSRGQVVLYGDDGVTIYIFLVITITTTLW 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC24A5	XP_047288350.1	2A1904	<20..>255	CDD:273344	41/199 (21%)
		2A1904	<321..521	CDD:273344	48/262 (18%)
CG14743	NP_610408.2	ECM27	106..>221	CDD:440296	30/162 (19%)
		PLN03151	<337..529	CDD:215604	36/192 (19%)
		Na_Ca_ex	450..591	CDD:426387	29/122 (24%)