Protein Alignment SLC24A5 and CG14744

DIOPT Version :10

• Sequence 1: XP_047288350.1
• Gene: SLC24A5 / 283652
• HGNCID: 20611
• Length: 531
• Species: Homo sapiens
• Sequence 2: NP_001097232.2
• Gene: CG14744 / 35858
• FlyBaseID: FBgn0033324
• Length: 620
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 121/587 - (20%)
• Similarity: 215/587 - (36%)
• Gaps: 191/587 - (32%)

Human    69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGKYCS 133
            ::..|:.:.:::: :|.....||.|.|:|||..|.:::.:||.||:|.|:.:||::       .:
  Fly    79 LLFAFICVAFLWL-MSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEII-------AN 135

Human   134 LYFLLTQCDFYFLQVNTNLA------GTILHIGVFITKGDIGISTILGSAIYNLLGICAACGLLS 192
            |..:......:.:.|...||      ||:..:..|...|    .:.|...::.|||:
  Fly   136 LMPVRADAPIFTITVGNTLAIILLSGGTVCFLRPFRMNG----HSTLRDLLFLLLGV-------- 188

Human   193 NTVSTLSCWPLFRDCAAYTI--SAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYI 255
                         :...:.:  ..|..||          ||.:|.|||.:||.:...|:.:.:|.
  Fly   189 -------------EVLRFVMIKEGAVTLG----------EGIVLFLIYVVYVAINIADLALLRYY 230

Human   256 IKKCSPCCACLAKAME-------------RSEQQPLMGWEDEGQPFIR-----RQSR-------- 294
            |:|       |.:.::             .::.:.|:.||::....|:     |:||
  Fly   231 IRK-------LRRELDYLEGLTPPPITEINAKIRKLISWEEQDDIGIKDTTKYRRSRDTGNHFSN 288

Human   295 -TDSGIF-------------YE-------DS---------------------------GYS---- 307
             |.||.|             ||       ||                           |:|
  Fly   289 MTSSGYFVTPIPERRSEHVDYELNRTALHDSENPKNLQLFTEFFQSLNPVDAEAWQLGGWSNRIY 353

Human   308 -----------QLSISL-------HGLS------QVSEDPPSVFNMPEADLKRIF---------- 338
                       ||.|.:       ||.|      |:..:|..|..:..:.:..::
  Fly   354 LIARCPLVFVLQLFIPVVDYEKIKHGWSKLLNCTQIVTNPFVVITLVHSGVSSVYKTWHITLDFS 418

Human   339 ---W--VLSLPIITLLFL-TTPDCRKKFWKNYFVITFF--MSAIWISAFTYILVWMVTITGETLE 395
               |  .|::|:..::|| :..|....:...:.::|||  |..:|: |.|.:.| :..|.|....
  Fly   419 ISMWSPCLTVPLAIVIFLHSRTDVPPSYHHLFIILTFFSSMVTLWL-AVTELEV-LSEIVGIVFN 481

Human   396 IPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFIKTAFINGSA 460
            :.::.|.:|..|...:.||.||:..:|.:|.|.||.:.|:|..||.:|.     .:..|||....
  Fly   482 LSESFMAVTFEAVSNATPDIIANYQLALQGYGRMAFAAIIGGPVFAILV-----SMSLAFIFNHR 541

Human   461 PAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLD------RKLGIVCLLSYLGLATLSVLYELG 519
            ..||.:....|..:..|..:..:...|....|.:.      |..|:...|.||.....:|..|..
  Fly   542 VREVGANSWVYGDLGDNCYLFLVITIVTTMWWSVTFDFHARRSAGVFLWLVYLQFLLYAVCVEWD 606

Human   520 II 521
            ::
  Fly   607 VV 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC24A5	XP_047288350.1	2A1904	<20..>255	CDD:273344	42/193 (22%)
		2A1904	<321..521	CDD:273344	51/223 (23%)
CG14744	NP_001097232.2	PLN03151	55..601	CDD:215604	119/578 (21%)
		Na_Ca_ex	450..601	CDD:426387	41/157 (26%)