DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TSSK4 and par-1

DIOPT Version :9

Sequence 1:	NP_001171668.1	Gene:	TSSK4 / 283629	HGNCID:	19825	Length:	338	Species:	Homo sapiens
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	323	Identity:	107/323 - (33%)
Similarity:	169/323 - (52%)	Gaps:	42/323 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFY 89
            |::.|.||.|::..|..|.:......||:|||.|.:.:...|.| |.||:::||:|.|..::..:
  Fly   253 YKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQK-LFREVRIMKMLDHPNIVKLF 316

Human    90 RAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRLMPSLSA 154
            :.||:...:|:|:|.|.||:|.:::..:|...|..|...|.|:...:.|.|.|.|:|
  Fly   317 QVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIH-------- 373

Human   155 AGRDLKLENLLLDKWENVKISDFGFA-KMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPE 218
              ||||.||||||...|:||:||||: :..|.::                 ..|:|||..||.||
  Fly   374 --RDLKAENLLLDSELNIKIADFGFSNEFTPGSK-----------------LDTFCGSPPYAAPE 419

Human   219 ILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTISQECKNLILQ 283
            :.:|..|:....|.||:||||||||...||||.:.|:: |||......:.....:|.:|:||:.:
  Fly   420 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRE-LRERVLRGKYRIPFYMSTDCENLLRK 483

Human   284 ML-RQATKRATILDIIKDSWV--------LK--FQPEQPTHEIRLLEAMCQL-HNTTKQHQSL 334
            .| ....|||::..|:.|.|:        ||  .:|:....:.:.:||:..: :|.::...||
  Fly   484 FLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TSSK4	NP_001171668.1	STKc_TSSK4-like	24..303	CDD:271064	98/279 (35%)
TSSK4	NP_001171668.1	S_TKc	25..303	CDD:214567	98/279 (35%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	98/279 (35%)
		S_TKc	253..504	CDD:214567	98/279 (35%)
		UBA_MARK_Par1	525..563	CDD:270522	5/22 (23%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910