Protein Alignment GPR12 and npr-19

DIOPT Version :10

• Sequence 1: NP_005279.1
• Gene: GPR12 / 2835
• HGNCID: 4466
• Length: 334
• Species: Homo sapiens
• Sequence 2: NP_508147.2
• Gene: npr-19 / 182130
• WormBaseID: WBGene00015364
• Length: 420
• Species: Caenorhabditis elegans
• Alignment Length: 337
• Identity: 71/337 - (21%)
• Similarity: 134/337 - (39%)
• Gaps: 66/337 - (19%)

Human    42 LVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLR-APMFLLIGSLALADLLAGIGLITNFVFAY 105
            :.|:.|.|:|..:  |||  |.:::..|..:.::| |..:..|.|:|:.|:|.....:.:.|.|.
 Worm    30 IAVSIWTIMLLYA--LIS--NMLILAGIARSSTMRSATSYWFIISIAICDILMTFISLGHLVPAT 90

Human   106 LLQSEATKLVTIGLIVASF------SASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVML 164
            ....|..:..:|..||..|      ...|..|..:..:|::|:.|.:.|  :...:.|..:.::|
 Worm    91 AFHEEYVQFKSIRNIVMIFFYDLFWYTGVVQLGLMAGNRFVSIVYPMEY--KHIFSRTRSLYLIL 153

Human   165 WGTSICLGL---LPVMGWNC---LRDESTCSVV--RPLTKNNAAILSVSFLFMFALMLQLYIQIC 221
            :|  ..||.   ||.: ::|   |.|.:....|  :|.|......::|:.:.:..:::...:.|.
 Worm   154 FG--YFLGFLVSLPTL-FDCCHTLWDSNYYITVYEKPDTLYKYVDMAVNSISLCMMIISYAVIIL 215

Human   222 KI------------VMRHAHQIALQHHFL---------ATSHYVTTRKGVS-------------T 252
            |:            .:|...|.||.:...         .||.....|..||             :
 Worm   216 KVRASGRAMAKYQLTIRTRQQNALVNGVSLSCQMSECGRTSSVRPPRSQVSKKEMRLFIQFFVVS 280

Human   253 LAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICC 317
            |..:|......|:|:...|..|.:...|::        ..|:.:||.:|...|.::::.|..:.|
 Worm   281 LVFLLTWTTWQWLPYMSESKWAYFVMTSLF--------FINNSVNPTVYIIFNTQLRRELHYLIC 337

Human   318 GCIPSSLAQRAR 329
            .....:.||..|
 Worm   338 RHHVITTAQNKR 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR12	NP_005279.1	7tmA_GPR12	45..312	CDD:320627	65/315 (21%)
		TM helix 1	46..72	CDD:320627	8/25 (32%)
		TM helix 2	79..104	CDD:320627	6/24 (25%)
		TM helix 3	113..143	CDD:320627	8/35 (23%)
		TM helix 4	155..175	CDD:320627	5/22 (23%)
		TM helix 5	194..223	CDD:320627	3/28 (11%)
		TM helix 6	244..274	CDD:320627	8/42 (19%)
		TM helix 7	280..305	CDD:320627	5/24 (21%)
npr-19	NP_508147.2	7tm_classA_rhodopsin-like	32..325	CDD:410626	65/309 (21%)
		TM helix 1	32..56	CDD:410626	9/27 (33%)
		TM helix 2	63..92	CDD:410626	7/28 (25%)
		TM helix 3	104..134	CDD:410626	7/29 (24%)
		TM helix 4	147..166	CDD:410626	5/20 (25%)
		TM helix 5	191..212	CDD:410626	1/20 (5%)
		TM helix 6	267..291	CDD:410626	2/23 (9%)
		TM helix 7	300..325	CDD:410626	6/32 (19%)