DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KSR2 and TPK3

DIOPT Version :9

Sequence 1:	NP_775869.4	Gene:	KSR2 / 283455	HGNCID:	18610	Length:	950	Species:	Homo sapiens
Sequence 2:	NP_012755.1	Gene:	TPK3 / 853688	SGDID:	S000001649	Length:	398	Species:	Saccharomyces cerevisiae

Alignment Length:	321	Identity:	62/321 - (19%)
Similarity:	127/321 - (39%)	Gaps:	83/321 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   595 PVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSI----- 654
            |:.:|.|.:.:...:.|..|.:..:::...|....::........::.|:..:...:.|.
Yeast     5 PMNNNEIRKLSITAKTETTPDNVGQDIPVNAHSVHEECSSNTPVEINGRNSGKLKEEASAGICLV 69

Human   655 ---FLQEWD----IPFEQLEIGELIGKGRFGQV------YHGRWHG------EVAIRLIDIERDN 700
               .||..|    ......:|...:|.|.||:|      ::||::.      ...::|..:|..|
Yeast    70 KKPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTN 134

Human   701 EDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ 765
            ::      |.:::.  ..|..::...|.......:.::....:|..|:|::|         |:::
Yeast   135 DE------RRMLSI--VSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLR---------KSQR 182

Human   766 I--------AQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGL--------FSISGVL 813
            .        |.|:...:.|||:|.|:::|||.:|:..| ||.:.|||||.        :::.|..
Yeast   183 FPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTP 247

Human   814 QAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF 874
            .                ::|||::         ...|::|..|.::.|.:.||:.|...||
Yeast   248 D----------------YIAPEVV---------STKPYNKSVDWWSFGVLIYEMLAGYTPF 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KSR2	NP_775869.4	KSR1-SAM	24..152	CDD:404435
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..296
		C1	408..464	CDD:412127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..556
		PK_KSR2	665..934	CDD:271055	51/239 (21%)
TPK3	NP_012755.1	STKc_PKA_like	86..376	CDD:270732	51/240 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910