DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KSR2 and DUN1

DIOPT Version :9

Sequence 1:	NP_775869.4	Gene:	KSR2 / 283455	HGNCID:	18610	Length:	950	Species:	Homo sapiens
Sequence 2:	NP_010182.1	Gene:	DUN1 / 851457	SGDID:	S000002259	Length:	513	Species:	Saccharomyces cerevisiae

Alignment Length:	300	Identity:	63/300 - (21%)
Similarity:	127/300 - (42%)	Gaps:	60/300 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   616 SENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIP---FEQLEIGELIGKGRF 677
            :::|:|..|:...::|.|......:||.|.....:..:|.......|   |::..:|:.:|.|.:
Yeast   147 NDDEKVSSESRSYKNDDEVFKKPQISATSSQNATTSAAIRKLNKTRPVSFFDKYLLGKELGAGHY 211

Human   678 GQVYHG---RWHGEVAIRLIDIERDNEDQL--KAFKREVMAYRQTRHENVVLFMGACMSP----- 732
            ..|...   :...:||:::...:: |:||.  |.|:.|.....:.:|.|:|..:.:.:.|
Yeast   212 ALVKEAKNKKTGQQVAVKIFHAQQ-NDDQKKNKQFREETNILMRVQHPNIVNLLDSFVEPISKSQ 275

Human   733 -PHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVF--- 793
             ....::..:..|.....:||  |..|..::::.:.::::.|:.|||.:.|:|:|:|.:|:.
Yeast   276 IQKYLVLEKIDDGELFERIVR--KTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNI 338

Human   794 -------------YDNG----KVVITDFGLFSISGVLQAGRREDKLRIQNGWLC----HLAPEII 837
                         :|..    :|.|.||||...:|.:|.          ...||    ::|||::
Yeast   339 TRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQF----------TNTLCGTPSYVAPEVL 393

Human   838 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQ 877
                     .|..::...|:::.|.|.|.......||..|
Yeast   394 ---------TKKGYTSKVDLWSAGVILYVCLCGFPPFSDQ 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KSR2	NP_775869.4	KSR1-SAM	24..152	CDD:404435
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..296
		C1	408..464	CDD:412127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..556
		PK_KSR2	665..934	CDD:271055	51/247 (21%)
DUN1	NP_010182.1	FHA	36..136	CDD:238017
DUN1	NP_010182.1	STKc_CAMK	199..479	CDD:270687	51/247 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910