DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KSR2 and CDC15

DIOPT Version :9

Sequence 1:	NP_775869.4	Gene:	KSR2 / 283455	HGNCID:	18610	Length:	950	Species:	Homo sapiens
Sequence 2:	NP_009411.2	Gene:	CDC15 / 851274	SGDID:	S000000072	Length:	974	Species:	Saccharomyces cerevisiae

Alignment Length:	333	Identity:	72/333 - (21%)
Similarity:	141/333 - (42%)	Gaps:	59/333 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   631 DFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHG-RWHGEVAIRLI 694
            |.:.:||:.:      ::||:.|:          |..:.::||:|.:|.||.. ..|.:..:.:.
Yeast     6 DTDRVNLTPI------QRASEKSV----------QYHLKQVIGRGSYGVVYKAINKHTDQVVAIK 54

Human   695 DIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLD 759
            ::..:|:::|.....|:...:...|.|:|.:.|.......|.|:...|...:|..::..:...|.
Yeast    55 EVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLS 119

Human   760 VNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFY--DNGKVVITDFGLFSI---SGVLQAGRRE 819
            .|:::....:.:.|:.|||.:|::|:|:|:.|:..  || .|.:.|||:.:|   |.:..||..
Yeast   120 ENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADN-TVKLADFGVSTIVNSSALTLAGTL- 182

Human   820 DKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIW 884
                   .|   :||||:......|         .||:::||....|:..:..|:.......|.:
Yeast   183 -------NW---MAPEILGNRGAST---------LSDIWSLGATVVEMLTKNPPYHNLTDANIYY 228

Human   885 --QMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMD----------MLEKLPKRNRR 937
              :..|...|:    ...:.:.|.|..|:.....:|||..:|:.          .::||.|....
Yeast   229 AVENDTYYPPS----SFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWINSTENVKVDKLNKFKED 289

Human   938 LSHPGHFW 945
            .:...:.|
Yeast   290 FTDADYHW 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KSR2	NP_775869.4	KSR1-SAM	24..152	CDD:404435
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..296
		C1	408..464	CDD:412127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..556
		PK_KSR2	665..934	CDD:271055	64/286 (22%)
CDC15	NP_009411.2	PKc_like	24..272	CDD:419665	62/272 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910