DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KSR2 and ksr2

DIOPT Version :9

Sequence 1:	NP_775869.4	Gene:	KSR2 / 283455	HGNCID:	18610	Length:	950	Species:	Homo sapiens
Sequence 2:	XP_009299513.1	Gene:	ksr2 / 569127	ZFINID:	ZDB-GENE-030131-8047	Length:	966	Species:	Danio rerio

Alignment Length:	980	Identity:	782/980 - (79%)
Similarity:	856/980 - (87%)	Gaps:	48/980 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVK 65
            |||||||||||.. ||||||||||||||||||:|||:|||||||||||||||||||||||.||||
Zfish     1 MDEENMTKSEEHH-LSLQKALQQCELVQNMIDISISSLEGLRTKCATSNDLTQKEIRTLEGKLVK 64

Human    66 YFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCET 130
            |||||||.|:||:||||||||||||:|.||||||::|||||||||||:|:||.||||.|:||||.
Zfish    65 YFSRQLSYKRKVSLQERNAELDGFPRLGHWFRIVNMRKEVLEEISPGELTLEALLEMVDDQVCEE 129

Human   131 VEKYGANREECARLNASLSCLRNVHMS-----------GGNLSKQDWTIQWPTTETGKENNPVCP 184
            ::|:||:.||||||||||||||:.|.|           ||  |||||:|||||:|:||||.||.|
Zfish   130 LKKFGASDEECARLNASLSCLRSAHQSEQLEDDKLHSNGG--SKQDWSIQWPTSESGKENTPVGP 192

Human   185 PEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYT---HVDRLTVDAYPGLCPPPPLESGHR 246
            .:.:.|:|..|||||::.|:..||.|.:......|.|:   |.|||||||:    .|.|||:||.
Zfish   193 SDHSQWVRLQLSQSPKLHSRYSQHLCQSPQALVPPFYSPHPHSDRLTVDAH----FPSPLETGHH 253

Human   247 SLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRS 311
            ||||||||||...||||||.:|.|:||||||.:|::||||.||||||:|||||||:|||||||||
Zfish   254 SLPPSPRQRHFAHTPPRTPLVVNTMTPPGTPQVRRRNKLKAPGTPPPASRKLIHLLPGFTALHRS 318

Human   312 KSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSV-GSCENIPSQQRSPLLSERSLRSFFVGHAPF 375
            ||||||||:|:|:|.|||||||:||||||||||| |||||:|: |||||.|:.||||||..:  |
Zfish   319 KSHEFQLGNRIDDAQTPKAKKKNKPLNLKIHSSVAGSCENLPT-QRSPLHSDHSLRSFFFPN--F 380

Human   376 LPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKN 440
            :|||||||::.. |||||||||||||||||||||||||||||||||||||.||||||||||||||
Zfish   381 VPSTPPVHSDTP-SANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCIVCGKGMLFGLKCKN 444

Human   441 CKLKCHNKCTKEAPPCHLLIIHRG--DPAR-------------LVRTESVPCDINNPLRKPPRYS 490
            ||||||||||||||||||||.|||  :|.|             |||||||||||||||    |||
Zfish   445 CKLKCHNKCTKEAPPCHLLIYHRGGREPFRDQVTSQGKEEARQLVRTESVPCDINNPL----RYS 505

Human   491 DLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQ 555
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..||
Zfish   506 DLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQSARQ 570

Human   556 QKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEE 620
            ||..||.|||:||||||||||||  .||.||||||||||||.|.|..:|:|||||||||||:|||
Zfish   571 QKQSNLTASHFYKYKQQFIFPDV--APEVPTRAPQVILHPVLSEPGPKGSPLLQIEVEPTSDNEE 633

Human   621 VHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRW 685
            .:||||.|.|:||||||||||||:||||||||||||||||||.||:|||||||||||||||||||
Zfish   634 GNDEAEGSADEFEEMNLSLLSARNFPRKASQTSIFLQEWDIPMEQVEIGELIGKGRFGQVYHGRW 698

Human   686 HGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSV 750
            ||||||||||||||||:|||||||||||||.||||||||||||||.|||||||||||||||||||
Zfish   699 HGEVAIRLIDIERDNEEQLKAFKREVMAYRNTRHENVVLFMGACMRPPHLAIITSLCKGRTLYSV 763

Human   751 VRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQA 815
            |||||:|||||||||||||:||||||||||||||||:||||||||||||||||||||:|||||||
Zfish   764 VRDAKVVLDVNKTRQIAQEMVKGMGYLHAKGILHKDMKSKNVFYDNGKVVITDFGLFTISGVLQA 828

Human   816 G-RREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPA 879
            | ||:|||||.:|||||||||:||||||:|.|::|||||.|||||.|||||||||||||||.|||
Zfish   829 GSRRKDKLRIPSGWLCHLAPELIRQLSPETAENQLPFSKQSDVFAFGTIWYELHAREWPFKNQPA 893

Human   880 EAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHF 944
            |.||||:|:||||.|:|||||||||||||||||:||||||:|:|||::||||||||||||||.||
Zfish   894 EVIIWQVGSGMKPILTQIGMGKEISDILLFCWAYEQEERPSFSKLMELLEKLPKRNRRLSHPVHF 958

Human   945 WKSAE 949
            |||||
Zfish   959 WKSAE 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KSR2	NP_775869.4	KSR1-SAM	24..152	CDD:404435	106/127 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..296		40/56 (71%)
		C1	408..464	CDD:412127	53/55 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..556		55/57 (96%)
		PK_KSR2	665..934	CDD:271055	239/269 (89%)
ksr2	XP_009299513.1	KSR1-SAM	23..151	CDD:290277	106/127 (83%)
		C1	417..459	CDD:237996	40/41 (98%)
		PKc_like	678..948	CDD:304357	239/269 (89%)
		Pkinase_Tyr	679..942	CDD:285015	233/262 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194342004
Domainoid	1	1.000	790	1.000	Domainoid score	I822
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45469
Inparanoid	1	1.050	1557	1.000	Inparanoid score	I858
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45551
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	1	1.000	-	-		oto46263
orthoMCL	1	0.900	-	-		OOG6_105530
Panther	1	1.100	-	-	LDO	PTHR23257
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.410