DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KSR2 and ksr

DIOPT Version :9

Sequence 1:	NP_775869.4	Gene:	KSR2 / 283455	HGNCID:	18610	Length:	950	Species:	Homo sapiens
Sequence 2:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster

Alignment Length:	1052	Identity:	345/1052 - (32%)
Similarity:	496/1052 - (47%)	Gaps:	251/1052 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    26 LVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFP 90
            ::|:|||||.::||||||:||.|:.|||:|||.||||||:|||..|..|.:  |.||.......|
  Fly    35 IIQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMR--LNERIPANGLVP 97

Human    91 -----QLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANR--EECARLNASL 148
                 :||.|.|:|.:.:..|........:||..|.::||::.:.:....:.|  ||..||..::
  Fly    98 HTTGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAM 162

Human   149 SCLRNV--HMSGGNLSKQDWTIQW-------PT-------TETGKENNPVCPPEPTPWIRTH--- 194
            ..||..  .:..|..:..:...||       ||       ...|..||....|      |||
  Fly   163 QNLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRGSVGNIGLGNNSTASP------RTHHRQ 221

Human   195 ---------LSQSPRVPSKCVQHYCHTSPTPGAPV-YTHVDRLTVDAYPGLCPPPPLESGHRSLP 249
                     |:.|....|.      ..||:....: .|...:||:.    |.|.||
  Fly   222 HGVKGKNSALANSTNFKSG------RQSPSATEELNSTQGSQLTLT----LTPSPP--------- 267

Human   250 PSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSH 314
                      ..|.||:...:.:..|||...:       ||||| :||...|:        |:||
  Fly   268 ----------NSPFTPSSGLSSSLNGTPQRSR-------GTPPP-ARKHQTLL--------SQSH 306

Human   315 EFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPST 379
            .     :||.....:.:..:.| :...|||..|                   ..||.     |:|
  Fly   307 V-----QVDGEQLARNRLPTDP-SPDSHSSTSS-------------------DIFVD-----PNT 341

Human   380 PPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLF-GLKCKNCKL 443
            ..  :....|:|.|.|| .||.:....:|::|||||:.......|||:|.|.:.. .:||.:||.
  Fly   342 NA--SSGGSSSNVLMVP-CSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVFHRWMKCTDCKY 403

Human   444 KCHNKCTKEAPP-CHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDL-HI-----SQTLPKT 501
            .||..|....|| |       |.|...|       |....:::...|:.| |:     ...|.|.
  Fly   404 ICHKSCAPHVPPSC-------GLPREYV-------DEFRHIKEQGGYASLPHVHGAAKGSPLVKK 454

Human   502 NKINKDHIPVPYQPDSSSNPSST-TSSTPSSPA------PPLPPSATPPSP-LHPSPQCTRQQKN 558
            :.:.|   |:..|...||:|||: |||||||||      ..|..:.:..|. |.|:|...:.|.:
  Fly   455 STLGK---PLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPSLGKHQPS 516

Human   559 FNLPASHYYKYKQQFIFPDVV----------------PVPETPTRAPQV---------------- 591
                         ||.||:|.                ||||....||..
  Fly   517 -------------QFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHM 568

Human   592 --ILHPVTSN----PILEGN----------------PLLQIEVEP----TSENEEVHDEAEESED 630
              ::...|||    ..|.|:                .|....|:.    |||..:.|    :|.|
  Fly   569 SSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTH----KSND 629

Human   631 DFEEMNLSLLSARSFPR--------------KASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVY 681
            ..:.::||..::....|              :..|.||.|:|||||:..|.:.|.||:||||.|:
  Fly   630 SDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVH 694

Human   682 HGRWHGEVAIRLIDIE-RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGR 745
            ...|||:||::|::.: ..:|..|:.|:.||..::.|||||:||||||||:||:|||:||||||.
  Fly   695 RALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGN 759

Human   746 TLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSIS 810
            |||:.:...:....:|:|..|||:|.:|||||||:.|:||||::||:|.:||||:||||||||.:
  Fly   760 TLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSST 824

Human   811 GVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDK-LPFSKHSDVFALGTIWYELHAREWPF 874
            .:|..   :..|.:.:.|||:||||:||.|.|:....: |.|:.:|||::.||:||||...|:.|
  Fly   825 KLLYC---DMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTF 886

Human   875 KTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRN--RR 937
            |.||||:||||:|.|||.:|:.:..|:::.|:|:.||.:|:|.||.|.:|:.:||.|||:.  |.
  Fly   887 KDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARS 951

Human   938 LSHPGHFWKSAE 949
            .|||.:..:|||
  Fly   952 PSHPVNLSRSAE 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KSR2	NP_775869.4	KSR1-SAM	24..152	CDD:404435	52/132 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..296		13/56 (23%)
		C1	408..464	CDD:412127	21/57 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..556		24/65 (37%)
		PK_KSR2	665..934	CDD:271055	135/270 (50%)
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	52/132 (39%)
		C1_1	368..419	CDD:278556	20/57 (35%)
		PK_KSR	678..946	CDD:270965	135/270 (50%)
		Pkinase_Tyr	679..940	CDD:285015	131/263 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	283	1.000	Domainoid score	I1649
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1655
Isobase	1	0.950	-	0	Normalized mean entropy	S4491
OMA	1	1.010	-	-		QHG45551
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	1	1.000	-	-		otm41675
orthoMCL	1	0.900	-	-		OOG6_105530
Panther	1	1.100	-	-	O	PTHR23257
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3270
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	13.010