DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KSR2 and ksr-1

DIOPT Version :9

Sequence 1:	NP_775869.4	Gene:	KSR2 / 283455	HGNCID:	18610	Length:	950	Species:	Homo sapiens
Sequence 2:	NP_509396.1	Gene:	ksr-1 / 181082	WormBaseID:	WBGene00002239	Length:	771	Species:	Caenorhabditis elegans

Alignment Length:	726	Identity:	208/726 - (28%)
Similarity:	337/726 - (46%)	Gaps:	135/726 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   294 SSRKLIHL----IPGFTALHRSKSHEFQ-LGHRVDEAHTPKAKKKSKPLNLKIH-------SSVG 346
            |::.:.||    |..|.||....:.|.: |..|.......|.|.....:.|:.|       :|.|
Worm    93 SAQNIRHLEICSITDFNALFSITNQELRSLADRGRLDVETKRKLLQSTVILQNHWNAYHSRTSSG 157

Human   347 SCENIPSQQRSPLLSERS----LRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDL 407
            |.:. ||.|.:|.:...|    :.|..|..|..:.|:         |....:.|: ||:...| |
Worm   158 STDE-PSGQSTPAIVTPSPKFNVPSLSVTSAKMIQSS---------SMGFATTPK-SPKTSSR-L 210

Human   408 GNSIKHRF--STKYWMS--QTCTVCGKGMLFGL-----KCKNCKLKCHNKCTKEA------PPCH 457
            .::|.|::  |||:..|  ..|..|.:.:.||.     ||::||.|.|.:|....      .|.|
Worm   211 VHAIPHKWHRSTKFRFSGDAVCHFCQRPLGFGFLNAWEKCRSCKWKVHTQCKGRVGDSCGLTPDH 275

Human   458 LLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSS-SNP 521
            |..:.    .:|::      :.|..:.|.|        |::|.:..:|:   |....||:: .:.
Worm   276 LRFLF----DKLIQ------ENNGGMWKDP--------QSVPGSRSMNE---PAFQFPDTAIDSS 319

Human   522 SSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPT 586
            |||.||.||:||.|...|....|...|                  |:.:::|:|||.... ....
Worm   320 SSTNSSAPSTPALPAGISGNVSSLTAP------------------YRSERKFLFPDTENY-SVHN 365

Human   587 RAPQVIL----HPVTSN-------------PILEGNPLLQIEVEPT--------SENEEVHDEAE 626
            |.|.:::    ||.|:.             ..:.||    ||.|.|        :.::||..||.
Worm   366 RLPILVISEGDHPTTTEIQQETENHNKSAAASMSGN----IESEGTIVANHEDSTGSQEVDSEAA 426

Human   627 ESEDDFEEMNLSLLSARSFPRKASQTSIF-----LQEWD---IPFEQLEIGE---LIGKGRFGQV 680
            .|::..::.|.......::.|.|...|..     ...|:   |.||.:|..:   :||:||||:|
Worm   427 PSQEAVDKFNKRADGGFTWERHAWNMSTIRGPNAQASWNEVTIQFETIEFDKQAPIIGRGRFGKV 491

Human   681 YHGRWHGEVAIRLIDIERDNEDQLKA--FKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCK 743
            ..|..:|:||:::..:|..::...||  ||.||.||:.|||:|:.||:|..||.....::.||.|
Worm   492 LRGFHYGDVAVKVYTMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQYGMVMSLSK 556

Human   744 G-RTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDN-GKVVITDFGL 806
            | ::||:::...:..||:..||:|||:|.:.:.|||.|.||||||:|||:..:: .||||||||:
Worm   557 GSQSLYTLLHVVREKLDLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGI 621

Human   807 FSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEE---DKLPFSKHSDVFALGTIWYELH 868
            .|:..:....::...| ....|..::|||:...:..:.:|   |..|||::|||:|.|.:|:|:.
Worm   622 LSMKRLAHPKQKSGYL-TSKFWTNYIAPELAMAMRTEYDEYECDDFPFSENSDVYAFGCVWFEML 685

Human   869 AREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPK 933
            ....|:..:....|::....|::|.|..:...:|:.::|:.||....::|||.|.:...|..|||
Worm   686 TGALPYAGELPHQILFAKTQGIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKLTALPK 750

Human   934 R---NRRLSHP 941
            :   ||..|.|
Worm   751 KPRVNRSPSFP 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KSR2	NP_775869.4	KSR1-SAM	24..152	CDD:404435
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..296		1/1 (100%)
		C1	408..464	CDD:412127	20/70 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..556		18/58 (31%)
		PK_KSR2	665..934	CDD:271055	99/278 (36%)
ksr-1	NP_509396.1	C1	216..269	CDD:237996	16/52 (31%)
		Pkinase_Tyr	474..741	CDD:285015	96/267 (36%)
		PKc_like	482..751	CDD:304357	98/269 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	179	1.000	Domainoid score	I2355
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I2619
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	1	1.000	-	-		mtm5004
orthoMCL	1	0.900	-	-		OOG6_105530
Panther	1	1.100	-	-	O	PTHR23257
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3270
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.000