DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KSR2 and ksr2

DIOPT Version :9

Sequence 1:	NP_775869.4	Gene:	KSR2 / 283455	HGNCID:	18610	Length:	950	Species:	Homo sapiens
Sequence 2:	XP_031748677.1	Gene:	ksr2 / 100498480	XenbaseID:	XB-GENE-484751	Length:	956	Species:	Xenopus tropicalis

Alignment Length:	966	Identity:	847/966 - (87%)
Similarity:	895/966 - (92%)	Gaps:	26/966 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVK 65
            |||:|:..|:| ||||||||||||||||||||:||||||||||||||||||||||||||||||||
Frog     1 MDEDNVPSSDE-QPLSLQKALQQCELVQNMIDISISNLEGLRTKCATSNDLTQKEIRTLESKLVK 64

Human    66 YFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCET 130
            |||||||||:|||||||||||:|||||.||||||::||||:|||.||||:||:||:|:|:|||||
Frog    65 YFSRQLSCKRKVALQERNAELEGFPQLMHWFRIVNIRKEVMEEIDPGQLTLEELLDMSDDQVCET 129

Human   131 VEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHL 195
            :||:||:.|||.||||||||||:||.||.:||||||.||||.||:|||||||...|...||||||
Frog   130 LEKFGASSEECDRLNASLSCLRSVHKSGSSLSKQDWAIQWPATESGKENNPVTQQETAQWIRTHL 194

Human   196 SQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRH-AVR 259
            ||||:|.|||:|||||. |....|:||:||||||:||||||...  |:||||||||||||| |..
Frog   195 SQSPKVQSKCIQHYCHL-PVAHGPMYTNVDRLTVEAYPGLCQLS--ETGHRSLPPSPRQRHTAHN 256

Human   260 TPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDE 324
            .||||||||||:|||||||:|:|||||||||||||||||||||||||:||||||||||:||||||
Frog   257 NPPRTPNIVTTMTPPGTPPVRRKNKLKPPGTPPPSSRKLIHLIPGFTSLHRSKSHEFQVGHRVDE 321

Human   325 AHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS 389
            :||||||||:||||||||:|||||||||| |||||||||||||||||:...||||||||||.: |
Frog   322 SHTPKAKKKNKPLNLKIHNSVGSCENIPS-QRSPLLSERSLRSFFVGYPSVLPSTPPVHTEPS-S 384

Human   390 ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAP 454
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   385 ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAP 449

Human   455 PCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSS 519
            ||||||||||  |||||||||||||||||||||||||||:|||||||||||||||||||||||||
Frog   450 PCHLLIIHRG--ARLVRTESVPCDINNPLRKPPRYSDLHVSQTLPKTNKINKDHIPVPYQPDSSS 512

Human   520 NPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLP---------------ASHYYKY 569
            ||||||||||||||||||||||||||||||||||||||.||||               .||||||
Frog   513 NPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKPFNLPGSNSTSHPCTSSLLQGSHYYKY 577

Human   570 KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEE 634
            |||||||||  |||.||||||||||||.||||.|||||||||||||||||:.::.||||||||||
Frog   578 KQQFIFPDV--VPEIPTRAPQVILHPVNSNPINEGNPLLQIEVEPTSENEDGNERAEESEDDFEE 640

Human   635 MNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERD 699
            ||..|||||:||||||||||||||||||||||||||:|||||||.||||||||||||||||||||
Frog   641 MNHLLLSARNFPRKASQTSIFLQEWDIPFEQLEIGEMIGKGRFGLVYHGRWHGEVAIRLIDIERD 705

Human   700 NEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTR 764
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   706 NEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTR 770

Human   765 QIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWL 829
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
Frog   771 QIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIPNGWL 835

Human   830 CHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNL 894
            ||||||||.|||||||||||||||||||||||||||||||||||||:|||||||||:|:||||||
Frog   836 CHLAPEIICQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKSQPAEAIIWQVGSGMKPNL 900

Human   895 SQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL 950
            :||||||||||||:|||.|||||||||||||:||||||||||||||||||||||||
Frog   901 AQIGMGKEISDILMFCWVFEQEERPTFTKLMEMLEKLPKRNRRLSHPGHFWKSAEL 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KSR2	NP_775869.4	KSR1-SAM	24..152	CDD:404435	109/127 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..296		46/57 (81%)
		C1	408..464	CDD:412127	55/55 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..556		57/57 (100%)
		PK_KSR2	665..934	CDD:271055	257/268 (96%)
ksr2	XP_031748677.1	KSR1-SAM	23..151	CDD:404435	109/127 (86%)
		C1	403..459	CDD:412127	55/55 (100%)
		PK_KSR2	671..940	CDD:271055	257/268 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	905	1.000	Domainoid score	I872
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45469
Inparanoid	1	1.050	1725	1.000	Inparanoid score	I1003
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45551
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	1	1.000	-	-		oto154170
Panther	1	1.100	-	-	LDO	PTHR23257
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080