Protein Alignment HECTD4 and pub1

DIOPT Version :9

• Sequence 1: NP_001103132.4
• Gene: HECTD4 / 283450
• HGNCID: 26611
• Length: 4428
• Species: Homo sapiens
• Sequence 2: NP_594396.1
• Gene: pub1 / 2541818
• PomBaseID: SPAC11G7.02
• Length: 767
• Species: Schizosaccharomyces pombe
• Alignment Length: 1086
• Identity: 205/1086 - (18%)
• Similarity: 326/1086 - (30%)
• Gaps: 435/1086 - (40%)

Human  3408 LLVISGIPTHLDEGVVRGAIRKACNAH-GGVFK----DEIYIPLQEEDTKKPKDKAE-------- 3459
            :|.:.|..||     ...||:|..|.: ...|:    |...|.:|..|.||.|.|.:
pombe    34 VLTVDGEQTH-----TTTAIKKTLNPYWNETFEVNVTDNSTIAIQVFDQKKFKKKGQGFLGVINL 93

Human  3460 ----------GGD-----------------GKV------EPEKTLAFPGTDSMEVSTSSSLTPAM 3491
                      |||                 ||:      ..:.||..|.:     :.|.:.|...
pombe    94 RVGDVLDLAIGGDEMLTRDLKKSNENTVVHGKIIINLSTTAQSTLQVPSS-----AASGARTQRT 153

Human  3492 SISASASTSQASICSSQGISQTVSDLSVDPLPAGLELPIPPGLLEPHAVSSQESLDISLCSTGSL 3556
            ||:....:||:|..|....|......:.|..||.     .|...||...||.|.         ..
pombe   154 SITNDPQSSQSSSVSRNPASSRAGSPTRDNAPAA-----SPASSEPRTFSSFED---------QY 204

Human  3557 GSLGSLGEPLDNAETASVSDMGSMYTVTSLDNQPLAARP----IKGFAVVEIRSRAKIEKIRASL 3617
            |.|....|       ....::|..|.|..........||    :.|.|..|:.|       .||.
pombe   205 GRLPPGWE-------RRTDNLGRTYYVDHNTRSTTWIRPNLSSVAGAAAAELHS-------SASS 255

Human  3618 FNNNDLIGLSSLDGEDELMEMSTEEILTVSVVNQSLFDTQGS----PGLEDYFNDKSIKGEKLVP 3678
            .|..:.:..||    ......:...:||.:..      |.||    ||.|          ::..|
pombe   256 ANVTEGVQPSS----SNAARRTEASVLTSNAT------TAGSGELPPGWE----------QRYTP 300

Human  3679 GAREVLTEIFKSCAHSEQTLSLTPAKPIRVSDIYLSKEQINSQTPGNLLHLFFTNVRPPKKVLED 3743
            ..|....:      |:.:|.                                 |.|.|.::
pombe   301 EGRPYFVD------HNTRTT---------------------------------TWVDPRRQ---- 322

Human  3744 QLTQILRKYGVPKPKFDKSKYSKAGKEQHPVKVVSTKRPITKPPAKDKAVLNSVSRTALSEKKPT 3808
               |.:|.||.|         :.|..:|.|   ||...|:   |:..:..|.:.:|....:
pombe   323 ---QYIRSYGGP---------NNATIQQQP---VSQLGPL---PSGWEMRLTNTARVYFVD---- 365

Human  3809 VKPKSPEKSKPDEKDPEKSPTK-KQEVPEEKYLTLEGFHKFVIDRARQDIRSVWRAILSCGYDLH 3872
                  ..:|....|..:.|:. .|.||:.|                :|.|
pombe   366 ------HNTKTTTWDDPRLPSSLDQNVPQYK----------------RDFR-------------- 394

Human  3873 FERCACIDVRHAQKASRKWTLEMDVALVQYINQLCRHLAITPARLHPHEVYLDPADAADPRVACL 3937
                            ||        |:.:::|        || |||
pombe   395 ----------------RK--------LIYFLSQ--------PA-LHP------------------ 408

Human  3938 LNVPIESLRLRFALLQSLNTTLETFFLPLVELRQTPMYTHSIAALLKEAKGLIFYDTKVTVMNRV 4002
                                              .|...|     :|..:..||.|:...:|
pombe   409 ----------------------------------LPGQCH-----IKVRRNHIFEDSYAEIM--- 431

Human  4003 LNATVQRTADHAAPEITLDPLEIVGGEIRASENSYFCQAARQLASVPSSQLCVKLASGGDPTYAF 4067
                                                    ||.|:....:|.:|
pombe   432 ----------------------------------------RQSATDLKKRLMIK----------- 445

Human  4068 NIRFTGEEVHGTSGSFRHFLWQVCKEL--------QSSSLS--LLLLCPSSAVNKNKGKYILTPS 4122
               |.||:.....|..|.:.:.:..|:        :.||:.  .|.:.|.|.:|         |.
pombe   446 ---FDGEDGLDYGGLSREYFFLLSHEMFNPFYCLFEYSSVDNYTLQINPHSGIN---------PE 498

Human  4123 PITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFE 4187
            .:.|     ..|:|:::|:||.....:....:.||:|.:    |..:..||:.:.:...|.:...
pombe   499 HLNY-----FKFIGRVIGLAIFHRRFVDAFFVVSFYKMI----LQKKVTLQDMESMDAEYYRSLV 554

Human  4188 SI--NDETELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDI 4250
            .|  ||.|.:..|...:...              |....:|     ::|...||:|.|..|||..
pombe   555 WILDNDITGVLDLTFSVEDN--------------CFGEVVT-----IDLKPNGRNIEVTEENKRE 600

Human  4251 YAAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQ 4315
            |...:...|::: :..|...|...|...:||.:|:.:....|:||...|:..|::|..|.||.|:
pombe   601 YVDLVTVWRIQK-RIEEQFNAFHEGFSELIPQELINVFDERELELLIGGISEIDMEDWKKHTDYR 664

Human  4316 VGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPD 4380
             ...|.||.|::||..::.::.|:..:.::|.....|||.     :|..|          :...|
pombe   665 -SYSENDQIIKWFWELMDEWSNEKKSRLLQFTTGTSRIPV-----NGFKD----------LQGSD 713

Human  4381 G-------TAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 4419
            |       .||.| ::..:..||...:.||.|:|.:.:..||..|:
pombe   714 GPRKFTIEKAGEP-NKLPKAHTCFNRLDLPPYTSKKDLDHKLSIAV 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HECTD4	NP_001103132.4	None
pub1	NP_594396.1	HUL4	1..767	CDD:227354	205/1086 (19%)
		C2_Smurf-like	9..131	CDD:176028	22/101 (22%)
		WW	207..236	CDD:278809	5/35 (14%)
		WW	290..319	CDD:278809	9/77 (12%)
		WW	346..378	CDD:197736	6/44 (14%)
		HECTc	413..765	CDD:238033	97/463 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910