Protein Alignment HECTD4 and ran-3

DIOPT Version :9

• Sequence 1: NP_001103132.4
• Gene: HECTD4 / 283450
• HGNCID: 26611
• Length: 4428
• Species: Homo sapiens
• Sequence 2: NP_495753.1
• Gene: ran-3 / 174332
• WormBaseID: WBGene00004304
• Length: 569
• Species: Caenorhabditis elegans
• Alignment Length: 639
• Identity: 118/639 - (18%)
• Similarity: 197/639 - (30%)
• Gaps: 245/639 - (38%)

Human  1892 SEQEDPSDPASKIASLLLAKLADYVVPGCQTVLSPTASEPDTTLTKTSPKNSLKGDKDPGEESEA 1956
            ||.|.|:|..::                 |...:|.|.:|:         :|..|.::.||:.|.
 Worm    11 SEVELPNDNVNE-----------------QGNKTPRADQPE---------SSASGARNHGEDEEV 49

Human  1957 VDGKLSIFIHKREDQSSHEVLQ--PLLSSSEGRPFRLGTGANMEKVVKMDRDMTKGGCCEVITEE 2019
            .:   .:.:...|.::|..::.  |......|||.:|.:                       |..
 Worm    50 TE---QVELAAMETEASDSIVDNVPKTPRRAGRPKKLPS-----------------------TST 88

Human  2020 AAAALRKATKWAQSGLIVSIGPPVESINPETVSGLSTGDKKK---TAQTSICRERNSELARTDPV 2081
            |||                     ||    .|:....|.|:|   :..|:|....||.|  .:|.
 Worm    89 AAA---------------------ES----AVTPGKRGRKRKGSESVNTTINSTMNSTL--NEPK 126

Human  2082 RPFISGHVANSMAAEVIALLHSLLMAPESNAAQIWTTTAEKVLSRALMYIPQLGKYAESILENGS 2146
            .|      ....|..|..||...|.||        :...::|||        .|: .|::...|.
 Worm   127 TP------GRKQAKLVAPLLTYDLFAP--------SIIGDRVLS--------CGE-GEALGHPGR 168

Human  2147 SSGRKLAKLQRIARQAVAALCALGGFKETIKIGSEVQVLGRGISGSIGVVASINEQEG----IAT 2207
            ::.:|..|:.....:.:..|.|:.|...:..:.||.:|...||:....|.|...|:||    .|.
 Worm   169 TTTKKPRKVDIFEEEGLKPLQAVAGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAK 233

Human  2208 VRFPPIDCRKTSQ-----ASDTLTIPLSRLCVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSLS 2267
            |:|.. |..|..:     |..:.|                  .::|::........|....|::.
 Worm   234 VKFEE-DIEKEGKIVMLAAGASFT------------------AALTDQGSVIAWGNLRNSNGNVD 279

Human  2268 IHTSLPATGDGSAPVMAV-------VRL------LAEIRTRACLV------MAQL--------LE 2305
            :|..|....:  |||:.|       |::      |..:..:.||:      |.||        :.
 Worm   280 VHPLLHKMQE--APVVIVHQAKRKIVKIAAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIR 342

Human  2306 DSLFCEEFIQQCPAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYRDCARPPPPPLQADRRQPK 2370
            ....|:|                    :|:.|.|                     ||:...:
 Worm   343 SKYMCDE--------------------SGDHLLV---------------------PLRFKHK--- 363

Human  2371 EITWSPSRVFPPVRACMFSSHLTSVTF----------------------LADPSAGGGLPRGTFI 2413
                  .:.|..|...:|:|...::..                      .||....|...|...:
 Worm   364 ------GKFFDVVAKNVFASGFWTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRV 422

Human  2414 YATSPLPVQAPSF-----YWEIEIVSYGDTDDDTGPIVSFGFTTEAEKRDGAWT 2462
            :    ||.:||:|     :..||.|.:.......|.:.:.|..|:.....|.||
 Worm   423 F----LPAEAPAFGAERTFVNIEGVQHVVILGSDGKVFAMGKNTDNALGLGNWT 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HECTD4	NP_001103132.4	None
ran-3	NP_495753.1	ATS1	163..569	CDD:227511	68/385 (18%)
		RCC1_2	189..215	CDD:290274	7/25 (28%)
		RCC1_2	246..276	CDD:290274	4/47 (9%)
		RCC1_2	302..331	CDD:290274	5/28 (18%)
		RCC1	510..565	CDD:278826

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900