Protein Alignment HECTD4 and herc-1

DIOPT Version :9

• Sequence 1: NP_001103132.4
• Gene: HECTD4 / 283450
• HGNCID: 26611
• Length: 4428
• Species: Homo sapiens
• Sequence 2: NP_490834.1
• Gene: herc-1 / 171700
• WormBaseID: WBGene00021685
• Length: 1019
• Species: Caenorhabditis elegans
• Alignment Length: 1333
• Identity: 254/1333 - (19%)
• Similarity: 421/1333 - (31%)
• Gaps: 481/1333 - (36%)

Human  3246 CGGSGGAAAGDQGRFSTYFHALMEGCLAVAE--VTLPTNMSVTASGVTSAT-------------- 3294
            ||.:|....|.:         |.|..:.|.|  :..|.:|..||  |||.|
 Worm     8 CGHTGEGQLGVR---------LSESTIQVPERIIGAPNDMDGTA--VTSVTCGEQHTVFLTKDGK 61

Human  3295 ----APNLSDSSSSSSSSPGQTPQSP-SLLSKRKKVKMKREKASSSGKRQSSRTVDSDPTVLSIG 3354
                ..|:.......|.:.|.....| |..|..|.:::       |..|..:.:|..|..|.: .
 Worm    62 MWSVGSNMDGQLGRGSRTEGSFSIYPVSWTSSAKIIQI-------SAGRSHTVSVTDDGRVFA-W 118

Human  3355 GSKPEDMLWFHRALTLLIILRHLTRKDPQGLGVTSDAI-----ADACQAL--------VGPTAHS 3406
            ||.....|......|        .:..|:.:...:|.:     ::.|.||        .|..|..
 Worm   119 GSNEHGQLGMESKFT--------WQGTPRRVQEINDIVQVASGSNHCIALDEGGRVFVWGEQADG 175

Human  3407 RLL-------VISGIPTHLDEGVVR---GAIR-KACNAHGGVF------KDEIYIPLQEEDTKKP 3454
            |.:       .:||:|      :||   ||.. .|.:|.|.||      ..|:.|     |..:|
 Worm   176 RCIHRPEPVEQLSGVP------IVRVLAGARHCLALSASGAVFTWGQNNSGELGI-----DDLRP 229

Human  3455 KDKAE-----GGDGKVEPE-------------KTLAFPGTDSM-------EVSTSSSLTPAMSIS 3494
            :...:     .|.|.||..             :|.:| |:|::       :|...::.|....:.
 Worm   230 QTSVQHVHQMDGLGVVEAACGDNHTVLLTHCGRTFSF-GSDALGQCGFGKKVEKRTNPTAVSDLI 293

Human  3495 ASASTSQASICSSQGISQTVSDLSVDPLPAGLELPIPPGLLEPHAVSSQESLDISLCSTGSLGS- 3558
            .|..|..|:     |...|::.....|.|.||.                        |:|.||:
 Worm   294 GSHVTRIAA-----GACHTIAICKGAPYPFGLN------------------------SSGQLGNG 329

Human  3559 -LGSLGEPLDNAETASVSDMGSMYTVTSLDNQPLAARPIKGFAVVEIRSRAKIEKIRASLFNNND 3622
             :.:...|....|...|:.:.:.|..|..                 :||...||:        |:
 Worm   330 KIMTQSTPRKTDELDHVTGVFAGYHQTFF-----------------VRSSGTIEQ--------NE 369

Human  3623 LIGLS-------SLDGEDELMEMSTEEILTVSVVNQSLFDTQGSPGLEDYFNDK----------- 3669
            ::|.|       .||.|.....:...:.|.|..:.:|:|.:..|..:...:.|:
 Worm   370 IVGPSCPMQYPIKLDHESLKKLLDEGDALEVMSLIESVFSSLASMNMSFLYKDERRYNVGFCFER 434

Human  3670 --SIKGEKLV---------PGAREVLTEIFKS--CAHSEQTLSLTPAKPIRV----SDIYLSKEQ 3717
              .|..::::         |..|:.:..|..|  .|..|.:.:|...:.:||    ..:.:..|.
 Worm   435 SHGIDMDQVMEAFMLFDEYPMKRQYMELIVDSLKIAFQEWSENLKGIECLRVLLMLPWLPIFTEN 499

Human  3718 INSQTPGNLLHLFFTNVRPP------------KKVLEDQLTQILRKYGVPKPKFDKSKYSKAGKE 3770
            :|.||        ..||..|            :..||...||:..::
 Worm   500 VNVQT--------IKNVHTPFVDAMCLITGDLRAALEKWWTQLSTRH------------------ 538

Human  3771 QHPVKVVSTKRPITKPPAKDKAVLNSVSRTALSEKKPTVKPKSPEKSKPDEKDPEKSPTKKQEVP 3835
                    .:|.:|            |.:||:         |:..|:|...:|
 Worm   539 --------FRRMVT------------VFKTAI---------KAMLKAKKGPRD------------ 562

Human  3836 EEKYLTLEGFHKFVIDRARQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKWTLEMDVALV 3900
                     .|||::             |:                   ||.|
 Worm   563 ---------CHKFIL-------------IM-------------------QKLS------------ 574

Human  3901 QYINQLCRHLAITPARLHPHEVYLDPADAADPRVACLLNVPIESLRLRFALLQSLNTTLETFFLP 3965
             .||: ..|:                             :|:|:.     .:..|||:::.....
 Worm   575 -LINK-TYHI-----------------------------IPLETF-----YIDELNTSVDLKLEY 603

Human  3966 LVEL-RQTP------MYTHSIAALLKEAKG-LIFYDTKVTVMNRVLNATVQRTAD-----HAAPE 4017
            ::|| ||.|      .:||....|...||| |||.:.       .|..|::|.:.     |....
 Worm   604 VLELTRQDPNKTELDYWTHFPFLLNGVAKGELIFVEA-------WLMQTLRRQSSLFNTAHGTII 661

Human  4018 ITLDPLEI-VGGEIRASENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSG 4081
            ..|..||: |..|...|:      ...|:|.:..|.|...|          .:...||:.....|
 Worm   662 FELPHLELTVRREFIVSD------TMNQMAGLSESDLQKPL----------KVNIAGEDADDAGG 710

Human  4082 SFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGKYILTPS--PITYGEEQLLHFLGQLLGIAI- 4143
            ..:.|...|.:::..|...:.        ::::..:::..|  |..:.:.:..|.||:|:|::|
 Worm   711 VRKEFFILVMRKILQSDYGMF--------SEDEESHLVWFSGLPSEFCDREQFHQLGRLVGLSIY 767

Human  4144 -RADVPLPLDLLPSFWKTLVGEPLDPEQDLQEAD---------ILTYNYVKKFESINDETELEAL 4198
             .:.||.|..|  :.:|.|:..|.|.| ||.|..         :|:|          :|.::|
 Worm   768 NHSIVPFPFPL--ALYKYLLDTPPDLE-DLCELSPSEGKGLKMLLSY----------EEDDVE-- 817

Human  4199 CAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLREL 4263
              ::...:.           |..|..|..| ...||.|.|....|...|:|.|.......||...
 Worm   818 --DVFGLNF-----------CISFNILGET-HTTELLSGGTEKPVTNANRDEYVRLYVHHRLELG 868

Human  4264 QNVECVTAV---RAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHI 4325
            .|.|.....   |.|....:..:.|....|.|::....|....:....:...||:.....:...|
 Worm   869 YNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTI 933

Human  4326 EFFWGALEMFTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRY 4390
            :.||.|....|.:|..||::|.....|||.:      |.:..|....|          .:|:|..
 Worm   934 QAFWKAFFALTDDERRKFLQFLTGSTRIPVS------GWEELHAAIQP----------SAPESLP 982

Human  4391 IRVETCMFMIKLPQYSSLEIMLEKLRCAIHYRE 4423
            : ..||..::.||..:....:|.:||.:|.:.|
 Worm   983 V-AHTCFNLLDLPNIADDVELLRRLRISIEHTE 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HECTD4	NP_001103132.4	None
herc-1	NP_490834.1	ATS1	2..359	CDD:227511	84/435 (19%)
		HECTc	667..1016	CDD:238033	90/418 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910