Protein Alignment MYO1H and MYO3

DIOPT Version :9

• Sequence 1: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_012793.2
• Gene: MYO3 / 853729
• SGDID: S000001612
• Length: 1272
• Species: Saccharomyces cerevisiae
• Alignment Length: 1080
• Identity: 360/1080 - (33%)
• Similarity: 550/1080 - (50%)
• Gaps: 200/1080 - (18%)

Human     8 RDKVGVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGV 72
            :.:||:.|..||...:.|| ..:||:|||...:||||||.:|:||||:::|||||.:.:|.|:|.
Yeast    33 KKEVGISDLTLLSKISDES-INENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGK 96

Human    73 NFFELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTC-PMTQSLQIAR 136
            |..|:||||:|||::.|..:.:...|..::||||||||||||:|:|::|.|... ..::|:...:
Yeast    97 NRLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASNSHSESIGKIK 161

Human   137 DRLLFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERN 201
            |.:|.:||:||:||.|:||||:||||.|||::|:|:.|..|..|:|.:||:||.|||.|.:.|||
Yeast   162 DMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNERN 226

Human   202 FHIFYQLLAGGEEERLSYLGLERDPQLYKYLSQGHCAKESSISDKNDWKTVSNAFSVIDFTEADL 266
            ||||||...|..:......|::. |:.|.|.:...|....:|.|..|::....|...|...:.:.
Yeast   227 FHIFYQFTKGASDTYKQMFGVQM-PEQYIYTAAAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQ 290

Human   267 ENLFGIIASVLHLGNIGFEEDDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHRKIEA----KT 327
            :.:|.::|::|.:|||.|.|:::|.|.:.||....::|.||.|..|:|::.|..|.::.    |.
Yeast   291 DQIFRMLAAILWIGNISFIENEEGNAQVGDTSVTDFVAYLLQVDASLLVKCLVERIMQTSHGMKR 355

Human   328 EEVI-CPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTVIGLLDIYGFEVFDKN 391
            ..|. .||....:...|||:|||:|...|.|:|:::|.||.......|: ||:|||||||:|:.|
Yeast   356 GSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPGADKS-IGILDIYGFEIFEHN 419

Human   392 GFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIICDLVEERH-KGIISILD 455
            .|||.||||.||||||:.|:.||||||..||.|.|:|.|||||:||::|||:|.:: .||::.::
Yeast   420 SFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDLIEAKNPPGILAAMN 484

Human   456 EECI---RPGPATDLSFLEKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKG 517
            :...   ....|.|.:|.::| .....:.:||.|.            .:|.:.||||:|||...|
Yeast   485 DSIATAHADSNAADQAFAQRL-NLFNSNPYFELRA------------NKFVIKHYAGDVTYDING 536

Human   518 FLEKNNDLLYRHLKEVLCKSKNIILRECFL-LAELENRRRPPTVGTQFKNSLSSLLETLISKEPS 581
            ..:||.|.|.:.|.|::..:.|..|...|. ..:.:::|||||.|.:...|.:.|:|||...|||
Yeast   537 ITDKNKDQLQKDLIELIGTTTNTFLSTIFPDDVDKDSKRRPPTAGDKIIKSANELVETLSKAEPS 601

Human   582 YIRCIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQR-YLGVELSHWVE 645
            |||.||||..|.|:.:||..:.||:|||||.|::|:||||||||:.:|.|::| ||
Yeast   602 YIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFYL--------- 657

Human   646 RLMMSLFYKDRYKSLCPDTWPHWHGPPAEGVERLIKYIGYKPEEYKLGKTKIFIRFPRTLFATED 710
             |.....|...|.         |.|...|.|:.:::......:|::||.|.:||:.|.:|||.||
Yeast   658 -LSPDCSYAGDYT---------WDGDTLEAVKLILRDAMIPEKEFQLGVTSVFIKTPESLFALED 712

Human   711 AFEFSKHQLVARIQATYKRCLGRR------------------EYVKKRQAAIKLEAHWRGALARK 757
            ..:...:.:.||||..::|.|.||                  :|||.|....||       ||.|
Yeast   713 MRDKYWYNMAARIQRAWRRFLQRRIDAAIKIQRTIREKKGGNKYVKLRDYGTKL-------LAGK 770

Human   758 AIQRRKWAVRIIRKFIKGFISRNKPLCPDNEEFIVFVRKNYILNLRYHLPKTVLDKSWLRPPGIL 822
            . :||..::...|.|:..::|.|:                         .||
Yeast   771 K-ERRSMSLLGYRAFMGDYLSCNE-------------------------SKT------------- 796

Human   823 ENASDLLRKMCVRNLVQKYCRGITAERKAMMQQKVVTSEIFRGRKDGYTESLNQPFVNSRIDEGD 887
                                :|....|:..::.|||.|  .:|      |.|:..|..|.
Yeast   797 --------------------KGSYIRRQVGIKDKVVFS--IKG------ECLHSKFGRSA----- 828

Human   888 INPKVLQLISHEKIQYGVPVIKYDRKGFKARQRQLILTQKAAYVV------ELAKIKQ--KIEYS 944
                                        :..::..|||:|..|::      ...|..|  ||:..
Yeast   829 ----------------------------QRLKKVFILTKKTFYIIGQTREQNAMKYTQDYKIDVG 865

Human   945 ALKGVSTSNLSD---GILVIHVSPEDSKQKGDAVLQCGHVFEAVTKLVMLVKKENIVNVVQGSLQ 1006
            .:|.||.:||.|   |::::      :..:.|.::......|.:|:|..|  .|.|:..|..:::
Yeast   866 KIKQVSLTNLQDDWMGVILV------NSTQSDPLINTPFKTELMTRLKKL--NEKIMIKVGPTIE 922

Human  1007 FFISPGKEGTI---VFDTGLE-EQVYKNKNGQLTVVSVRR 1042
            :...|.|..|:   :.|:..: ..:||:     :.:.|||
Yeast   923 YHKQPNKLHTVRSKISDSAPKYGDIYKS-----STIYVRR 957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1H	XP_011536525.1	MYSc	8..711	CDD:214580	290/714 (41%)
		MYSc_Myo1	26..700	CDD:276829	278/685 (41%)
		Myosin_TH1	856..1019	CDD:283635	36/176 (20%)
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	360/1080 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770