Protein Alignment MYO1H and Mhc

DIOPT Version :10

• Sequence 1: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1064
• Identity: 337/1064 - (31%)
• Similarity: 519/1064 - (48%)
• Gaps: 183/1064 - (17%)

Human    22 YTSESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGVNFFELPPHVYAIAD 86
            |.::::.:.|||:|:...|||||.|...|::|||:...:||....::|:|....|:|||::||:|
  Fly    96 YLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISD 160

Human    87 NAYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTCPMTQSLQIAR------DRLLFSNPV 145
            .||..|.....|..:||:|||||||||.:||::.|||......::.:.|:      |:::.:|||
  Fly   161 GAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPV 225

Human   146 LEAFGNARTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNFHIFYQLLA 210
            |||||||:|:||||||||||::.|.|...|...|..|.:||:||:||:.|...||::|||||:::
  Fly   226 LEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMS 290

Human   211 GGEEERLSYLGLE----RDPQLYKY--LSQGHCAKESSISDKNDWKTVSNAFSVIDFTEADLENL 269
            |      |..|::    ....:|.|  :|||. ...:||.|..::.....||.::.||:.:.|::
  Fly   291 G------SVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDV 348

Human   270 FGIIASVLHLGNIGFEE---DDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHRKIEAKTEEVI 331
            :.|.|:|:|:|.:.|::   ::|  |......|...::||.|...:.|.:.|...:|:...|.|.
  Fly   349 YRITAAVMHMGGMKFKQRGREEQ--AEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVT 411

Human   332 CPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTVIGLLDIYGFEVFDKNGFEQF 396
            ....::....:..|:.|.|:.|.|.|||.|.|.:|..:. .|:..||:|||.|||:|:.|||||.
  Fly   412 QGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQ-KRQHFIGVLDIAGFEIFEYNGFEQL 475

Human   397 CINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIIC-DLVEERHKGIISILDEECIR 460
            |||:.||||||.........||.||:.|||||..|.:..:..:| ||: |:..||:|||:||.:.
  Fly   476 CINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLI-EKPMGILSILEEESMF 539

Human   461 PGPATDLSFLEKL-EEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKGFLEKNND 524
            | .|||.:|.||| ...:||.|.|:..|...| |::.   ..|.:.||||.|:|...|:||||.|
  Fly   540 P-KATDQTFSEKLTNTHLGKSAPFQKPKPPKP-GQQA---AHFAIAHYAGCVSYNITGWLEKNKD 599

Human   525 LLYRHLKEVLCKSKNIILRECFL----------LAELENRRRP---PTVGTQFKNSLSSLLETLI 576
            .|...:.:...||:|.:|.|.|.          .|:....::.   .||.:.:|..|:||:.||.
  Fly   600 PLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLR 664

Human   577 SKEPSYIRCIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYLGVELS 641
            |.:|.::|||.||:.|:|...|..|:.||:...|::|.:|:.|.||..|..|..|
  Fly   665 STQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDF---------- 719

Human   642 HWVERLMMSLFYKDRYKSLCPDTWPHWHGPPAEGVER-------LIKYIGYKPEEYKLGKTKIFI 699
                        |.|||.:||..        .:|||:       :||:|....::|:||.||:|.
  Fly   720 ------------KMRYKIMCPKL--------LQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFF 764

Human   700 RFPRTLFATEDAFEFSKHQLVARIQATYKRCLGRREYVKKRQAAIKLEAHWRGALARKAIQRRKW 764
            | ...|...|:..:....::::.:||..:..|.|:.:.|.::..:.|:...|.  .||.:|.|.|
  Fly   765 R-AGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRN--LRKYLQLRTW 826

Human   765 A-VRIIRKF--------IKGFISRNKPLCPDNEEF---IVFVRKNY-ILNLRYHLPKTVLDKSWL 816
            . .::.:|.        |:..|:|.:......||.   .|.|||.. .||.:....||.|..|..
  Fly   827 PWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLS 891

Human   817 RPPGILE-----NASDLLRKMCVRNLVQKYCRGITAE---RKAMMQQK----------------- 856
            ...|.|:     ||....:|..:.|.::.....:|.|   |..:.|||
  Fly   892 GEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDL 956

Human   857 ---VVTSEIFRGRKDGYTESLNQPFVNSRIDE------------GDINPKVLQLISHEKIQYGVP 906
               |..:|..:..||....:||....:.  ||            |:.|.|     :.|::|....
  Fly   957 ELNVQKAEQDKATKDHQIRNLNDEIAHQ--DELINKLNKEKKMQGETNQK-----TGEELQAAED 1014

Human   907 VIKYDRKGFKARQRQ-----------------------------LILTQKAAYVVELAKIKQKIE 942
            .|.:..| .||:..|                             |.|||:|  |.:|.:.|:::|
  Fly  1015 KINHLNK-VKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEA--VADLERNKKELE 1076

Human   943 YSAL---KGVS--TSNLSDGILVI 961
            .:..   |.:|  |:.|.|..:|:
  Fly  1077 QTIQRKDKELSSITAKLEDEQVVV 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1H	XP_011536525.1	MYSc_Myo1	26..700	CDD:276829	260/710 (37%)
		Adgb_C_mid-like	<696..>763	CDD:412094	15/66 (23%)
		globin helix H	696..720	CDD:412094	5/23 (22%)
		IQ motif	744..762	CDD:412094	5/17 (29%)
		Myosin_TH1	856..1037	CDD:461801	34/172 (20%)
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	260/710 (37%)
		Myosin_tail_1	842..1922	CDD:460256	60/269 (22%)