Protein Alignment MYO1H and Mhc

DIOPT Version :9

• Sequence 1: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_001162991.1
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1058
• Identity: 334/1058 - (31%)
• Similarity: 511/1058 - (48%)
• Gaps: 189/1058 - (17%)

Human    31 NLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGVNFFELPPHVYAIADNAYRMMCAE 95
            |||:|:...|||||.|...|::|||:...:||....::|:|....|:|||::||:|.||..|...
  Fly   105 NLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTN 169

Human    96 LNNHFILISGESGAGKTEASKKILEYFAVTCPMTQSLQIAR------DRLLFSNPVLEAFGNART 154
            ..|..:||:|||||||||.:||::.|||......::.:.|:      |:::.:||||||||||:|
  Fly   170 HVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKT 234

Human   155 LRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNFHIFYQLLAGGEEERLSY 219
            :||||||||||::.|.|...|...|..|.:||:||:||:.|...||::|||||:::|      |.
  Fly   235 VRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG------SV 293

Human   220 LGLE----RDPQLYKY--LSQGHCAKESSISDKNDWKTVSNAFSVIDFTEADLENLFGIIASVLH 278
            .|::    ....:|.|  :|||. ...:||.|..::.....||.::.||:.:.|:::.|.|:|:|
  Fly   294 PGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMH 357

Human   279 LGNIGFEE---DDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHRKIEAKTEEVICPLTLELSV 340
            :|.:.|::   ::|  |......|...::||.|...:.|.:.|...:|:...|.|.....::...
  Fly   358 MGGMKFKQRGREEQ--AEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVT 420

Human   341 YARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKL 405
            .:..|:.|.|:.|.|.|||.|.|.:|..:. .|:..||:|||.|||:|:.|||||.|||:.||||
  Fly   421 NSIGALCKGVFDRLFKWLVKKCNETLDTQQ-KRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKL 484

Human   406 QQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIIC-DLVEERHKGIISILDEECIRPGPATDLSF 469
            ||.........||.||:.|||:|..|.:..:.:.| ||: |:..||:|||:||.:.| .|||.:|
  Fly   485 QQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLI-EKPMGILSILEEESMFP-KATDQTF 547

Human   470 LEKL-EEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKGFLEKNNDLLYRHLKEV 533
            .||| ...:||.|.|:..|...| |::.   ..|.:.||||.|:|...|:||||.|.|...:.:.
  Fly   548 SEKLTNTHLGKSAPFQKPKPPKP-GQQA---AHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQ 608

Human   534 LCKSKNIILRECFL----------LAELENRRRP---PTVGTQFKNSLSSLLETLISKEPSYIRC 585
            ..||:|.:|.|.|.          .|:....::.   .||.:.:|..|:||:.||.|.:|.::||
  Fly   609 FKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRC 673

Human   586 IKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYLGVELSHWVERLMMS 650
            |.||:.|:|...|..|:.||:...|::|.:|:.|.||..|..|..|
  Fly   674 IIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDF------------------- 719

Human   651 LFYKDRYKSLCPDTWPHWHGPPAEGVER-------LIKYIGYKPEEYKLGKTKIFIRFPRTLFAT 708
               |.|||.:||..        .:|||:       :||:|....::|:||.||:|.| ...|...
  Fly   720 ---KMRYKIMCPKL--------LQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFR-AGVLGQM 772

Human   709 EDAFEFSKHQLVARIQATYKRCLGRREYVKKRQAAIKLEAHWRGALARKAIQRRKW--------- 764
            |:..:....::::.:||..:..|.|:.:.|.::..:.|:...|.  .||.:|.|.|
  Fly   773 EEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRN--LRKYLQLRTWPWYKLWQKV 835

Human   765 --AVRIIRKFIKGFISRNKPLCPDNEEF---IVFVRKNY-ILNLRYHLPKTVLDKSWLRPPGILE 823
              .:.:.|  |:..|:|.:......||.   .|.|||.. .||.:....||.|..|.....|.|:
  Fly   836 KPLLNVSR--IEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQ 898

Human   824 -----NASDLLRKMCVRNLVQKYCRGITAE---RKAMMQQK--------------------VVTS 860
                 ||....:|..:.|.::.....:|.|   |..:.|||                    |..:
  Fly   899 DYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKA 963

Human   861 EIFRGRKDGYTESLNQPFVNSRIDE------------GDINPKVLQLISHEKIQYGVPVIKYDRK 913
            |..:..||....:||....:.  ||            |:.|.|     :.|::|.....|.:..|
  Fly   964 EQDKATKDHQIRNLNDEIAHQ--DELINKLNKEKKMQGETNQK-----TGEELQAAEDKINHLNK 1021

Human   914 GFKARQRQ-----------------------------LILTQKAAYVVELAKIKQKIEYS----- 944
             .||:..|                             |.|||:|  |.:|.:.|:::|.:
  Fly  1022 -VKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEA--VADLERNKKELEQTIQRKD 1083

Human   945 -ALKGVSTSNLSDGILVI 961
             .|..: |:.|.|..:|:
  Fly  1084 KELSSI-TAKLEDEQVVV 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1H	XP_011536525.1	MYSc	8..711	CDD:214580	262/716 (37%)
		MYSc_Myo1	26..700	CDD:276829	259/705 (37%)
		Myosin_TH1	856..1019	CDD:283635	33/173 (19%)
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	262/718 (36%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	259/705 (37%)
		Myosin_tail_1	842..1897	CDD:279860	60/272 (22%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910