Protein Alignment MYO1H and myo1

DIOPT Version :10

• Sequence 1: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_595402.1
• Gene: myo1 / 2539659
• PomBaseID: SPBC146.13C
• Length: 1217
• Species: Schizosaccharomyces pombe
• Alignment Length: 1077
• Identity: 370/1077 - (34%)
• Similarity: 532/1077 - (49%)
• Gaps: 208/1077 - (19%)

Human     6 TARDKVGVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQ 70
            |.:..|||.|..||...|.|. ...||..||....||||||.:|:||||:::|||||:..::.||
pombe    35 TRKKTVGVDDLTLLSKITDEE-INKNLELRFRNGEIYTYIGHVLISVNPFRDLGIYTMDILKSYQ 98

Human    71 GVNFFELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEASKKILEYFA-VTCPMTQSLQI 134
            |.|..|..|||||||:|||..|.:...|..|:||||||||||||:|:|::|.. |:..:...::.
pombe    99 GKNRLETSPHVYAIAENAYYQMKSYHENQCIIISGESGAGKTEAAKRIMQYITHVSKSVGTEIER 163

Human   135 ARDRLLFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGE 199
            ..:.:|.:||:||:||.|:||||:||||.|||:::.|:..|:|||..|.:||:||:|:|.|...|
pombe   164 VSEIILATNPLLESFGCAKTLRNNNSSRHGKYLEMIFNSGGVPVGAKITNYLLEKNRIVNQVRNE 228

Human   200 RNFHIFYQLLAGGEEERLSYLGLERDPQLYKYLSQGHCAKESSISDKNDWKTVSNAFSVIDFTEA 264
            ||||||||......::.....|:: .|:.|.|.|...|.....|||:.|::...||..||..||.
pombe   229 RNFHIFYQFTKSAPQKYRDTYGIQ-GPENYVYTSACQCLSVDGISDEKDFQGTMNAMKVIGITEP 292

Human   265 DLENLFGIIASVLHLGNIGFEEDDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHRKIEAK--- 326
            :.:.:|.:::.:|.||||.|:|...|.:.|.|....:::..|:||..:.:..|||.|.::.:
pombe   293 EQDEIFRMLSIILWLGNIQFQEGQDGGSVISDKSITEFLGYLIGVPVAAIERALTIRIMQTQHGA 357

Human   327 ----TEEVICPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTVIGLLDIYGFEV 387
                ..||  ||....::..|||::.|:|...|.|:|.::|.:||..|.:....||:|||||||:
pombe   358 RRGSVYEV--PLNPTQALAVRDALSMAIYNCLFDWIVERVNKALVTSDNSVSNSIGILDIYGFEI 420

Human   388 FDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIICDLVE-ERHKGII 451
            |:.|.|||.||||.||||||:.||.|||.||.||..|.|.|.||||||||::|||:| :|..|:.
pombe   421 FENNSFEQLCINYVNEKLQQIFIELTLKTEQEEYVREQIAWTPIKYFNNKVVCDLIESKRPPGLF 485

Human   452 SILDEECI---RPGPATDLSFLEKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTY 513
            :.:::...   ....|.|.:|.::| ..:..:.|||.|:            .:|.:.||||:|||
pombe   486 AAMNDAIATAHADSAAADSAFAQRL-NFLSSNPHFEQRQ------------NQFIVKHYAGDVTY 537

Human   514 CTKGFLEKNNDLLYRHLKEVLCKSKNIILRECFLLAELEN-RRRPPTVGTQFKNSLSSLLETLIS 577
            ...|..:||.|.|...:..::..|.|..::..|.:||..| ||||||.|.:.|.|.:.|:|||:.
pombe   538 SITGMTDKNKDQLATDILNLIHSSNNEFMKSIFPVAEESNSRRRPPTAGDRIKTSANDLVETLMK 602

Human   578 KEPSYIRCIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRY--LGVEL 640
            .:|||||.||||..|.|:.:|..::.||||||||.|::|:||||||||:.::.|.||:  |..:.
pombe   603 CQPSYIRTIKPNQTKSPNDYDQQMVLHQIKYLGLQENIRIRRAGFAYRQAFDTFAQRFAVLSGKT 667

Human   641 SHWVERLMMSLFYKDRYKSLCPDTWPHWHGPPAEGVERLIKYIGYKPEEYKLGKTKIFIRFPRTL 705
            |           |...|.         |.|......|:::|.......||::|.:|:||:.|.||
pombe   668 S-----------YAGEYT---------WQGDDKSACEQILKDTNIPSSEYQMGTSKVFIKNPETL 712

Human   706 FATEDAFEFSKHQLVARIQATYKRCLGRREYVKKR-QAAIKLEAHWR---------------GAL 754
            ||.||..:.....:..|||..:      |.||::| :||..::..|.               ..|
pombe   713 FALEDMRDKFWDTMATRIQRAW------RSYVRRRSEAAACIQKLWNRNKVNMELERVRNEGTKL 771

Human   755 ARKAIQRRKWAVRIIRKFIKGFISRNKPLCPDNEEFIVFVRKNYILNLRYHLPKTVLDKSWLRPP 819
            .:...|||::::...|||...::|.:||              |..|              | ...
pombe   772 LQGKKQRRRYSILGSRKFYGDYLSASKP--------------NGTL--------------W-NTC 807

Human   820 GILENASDLLRKMCVRNLVQKYCRGITAERKAMMQQKVVTSEIFRGRKDGYTESLNQPFVNSRID 884
            |:.:|...:....| ..||.|..|               ||
pombe   808 GLSQNDHVIFSMRC-EVLVHKLGR---------------TS------------------------ 832

Human   885 EGDINPKVLQLISHEKIQYGVPVIKYDRKGFKARQRQLILTQKAAYVVELAKI---------KQK 940
                                           |...|||:||:|..|:| :.||         ::|
pombe   833 -------------------------------KPSPRQLVLTKKNLYLV-ITKIVDQKLTQQVEKK 865

Human   941 IEYSALKGVSTSNLSDGILVIHVSPEDSKQKGDAVLQCGHVFEAVTKLVMLVKKENIVNVVQGSL 1005
            ...|::..|..:||.|..:.|.   ..|.|.||..|:|....|.:|.|..:  ..||..:|..::
pombe   866 FAVSSIDSVGLTNLQDDWVAIR---NKSSQNGDMFLRCFFKTEFITTLKRI--NRNIQVIVGPTI 925

Human  1006 QFFISPG-------------------KEGTIVFDTGL 1023
            |:...||                   |.|||...|||
pombe   926 QYCRKPGKVQTVKTAKDETTKDYDYYKSGTIHVGTGL 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1H	XP_011536525.1	MYSc_Myo1	26..700	CDD:276829	281/688 (41%)
		Adgb_C_mid-like	<696..>763	CDD:412094	23/82 (28%)
		globin helix H	696..720	CDD:412094	10/23 (43%)
		IQ motif	744..762	CDD:412094	3/32 (9%)
		Myosin_TH1	856..1037	CDD:461801	42/196 (21%)
myo1	NP_595402.1	COG5022	1..1217	CDD:227355	370/1077 (34%)