Protein Alignment MYO1H and hum-5

DIOPT Version :9

• Sequence 1: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_497809.1
• Gene: hum-5 / 175521
• WormBaseID: WBGene00002038
• Length: 1017
• Species: Caenorhabditis elegans
• Alignment Length: 1091
• Identity: 417/1091 - (38%)
• Similarity: 589/1091 - (53%)
• Gaps: 155/1091 - (14%)

Human    12 GVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGVNFFE 76
            ||:|.|||.....:|. |.||:.||.:..||||||.:||:||||::||||..|.::.|:|...:|
 Worm    12 GVEDLVLLSTIDLKSV-VQNLQLRFQKGRIYTYIGEVLVAVNPYRQLGIYEKSTVDQYKGREIYE 75

Human    77 LPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTCPMTQSLQIARDR--L 139
            ..|||:||||.|||.|.....:..|:|||||||||||.||.|::|.|....:.|..:|.|.:  |
 Worm    76 RAPHVFAIADAAYRSMKRFGRDSCIVISGESGAGKTETSKIIMKYLAAITNVRQQGEIERVKNVL 140

Human   140 LFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNFHI 204
            |.||.:|||||.|:|.||||||||||||.|.||:.|.||||:|.:||:||||||.|.|||||||:
 Worm   141 LRSNCILEAFGCAKTTRNDNSSRFGKYMHINFDYDGDPVGGNISNYLLEKSRVVRQQEGERNFHV 205

Human   205 FYQLLAGGEEERLSYLGLERDPQLYKYLSQGHCAKESSISDKNDWKTVSNAF-SVIDFTEADLEN 268
            ||||:.||::..|...||.:|.:.|.:|:||...|.:||:|..|:..|..|. |:..|.:.|:|:
 Worm   206 FYQLVNGGDDGLLRQFGLTKDAKQYYFLNQGQSHKVASINDSRDFAEVQTALRSIHTFDKQDVES 270

Human   269 LFGIIASVLHLGNIGF--EEDDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHRKIEAKTEEVI 331
            ::.:||.::||||:.|  .|:..|...|.:...::..|:.|.|.|..|.::|:.:.:.|..:.|.
 Worm   271 MWSVIAGLIHLGNVRFIDGENSSGAVHIAEKAALQNAARCLNVTPDELAKSLSSQVVAAHGDIVK 335

Human   332 CPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLV---NKDFTRKTVIGLLDIYGFEVFDKNGF 393
            ....:..:.|.|||:|||:|.|.|:|:|:|:|.::.   :..:::..|||:|||||||:|..|.|
 Worm   336 KQHDVNAAYYTRDALAKALYERLFSWMVSKVNEAISVQNSSRYSKSHVIGVLDIYGFEIFGTNSF 400

Human   394 EQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIICDLVEERHKGIISILDEEC 458
            ||.||||||||||||.||..||.||.|||.|||:|..|:|||||:||||||....||:|||||.|
 Worm   401 EQLCINYCNEKLQQLFIELVLKQEQEEYEREGIKWVKIEYFNNKVICDLVEIPRTGILSILDEAC 465

Human   459 IRPGPATDLSFLEKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKGFLEKNN 523
            ...|..||..||.:|::|:..|.|:.:|.|  .:..|.:|:.||::.||||:|||...||::||.
 Worm   466 ASIGNVTDKVFLGELDKKLKSHKHYTSRNL--KQSDKSMGFEEFKITHYAGDVTYSVMGFMDKNK 528

Human   524 DLLYRHLKEVLCKSKNIILRECF-----LLAELENRRRPPTVGTQFKNSLSSLLETLISKEPSYI 583
            |.|::.||.:|..|||.:::..|     .:||:  .|||||.|..||||:|.|::.|..|||.||
 Worm   529 DTLFQDLKRLLYHSKNRLVKSLFPDGSKSMAEV--NRRPPTAGFLFKNSMSELVKQLAQKEPHYI 591

Human   584 RCIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYLGVELSHWVERLM 648
            ||||||:.|..:.||...:.||::||||:|::||||||||:|..|:.|:
 Worm   592 RCIKPNEEKNSNVFDLERVEHQVRYLGLLENVRVRRAGFAHRMPYDRFV---------------- 640

Human   649 MSLFYKDRYKSLCPDTWPHWHGPPAEGVE------RLIKYIGYKPEEYKLGKTKIFIRFPRTLFA 707
                  :|||.:|..|||:    |..|.:      ::::..|. .::...|:||||||.|:|:|.
 Worm   641 ------NRYKLICASTWPN----PRRGQQLKDSCMQILESAGL-AQDCVQGRTKIFIRSPQTVFR 694

Human   708 TEDAFEFSKHQLVARIQATYKRCLG--RREYVKKRQAAIKLEAHWRGALARKAIQRRKW----AV 766
            .|   |....||...|....|...|  :||..::..|..|:    .||..|..::...|    |.
 Worm   695 LE---ELRTEQLPNVITFLQKMVRGVQQRERYRRMLAVRKI----IGAYRRYKLKSYIWQLINAF 752

Human   767 RIIRKFIKGFISRNKPLCPDNEEFIVFVRKNYILNLRYHLPKTVLDKSWLRPPGILENASDLLRK 831
            |.:|:.                               ..|.|::   .|..||.:|......||.
 Worm   753 RDVRRM-------------------------------RDLGKSI---RWPAPPLVLAQFVSRLRV 783

Human   832 MCVRNLVQKYCRGITAERKAMMQQKVVTSEIFRGRKD--GYT-----------ESLNQPFVNSRI 883
            |..|.........:....:|.:.||:...|:...:|:  |||           |.|..|...|..
 Worm   784 MHQRWRAATILARMPPHLRASLPQKIAAFEVLNNKKENWGYTRMWRGDYLSQQEELELPTTVSTY 848

Human   884 DEGDINPKVLQLI--SHE--KIQYGVPVIKYDRKGFKARQRQLILTQKAAYVVELAK---IKQKI 941
            .:|      :|.:  ||.  |:.:...|.|:: |..|:..|.||:|.:....:|..|   :|:.|
 Worm   849 HDG------IQALRQSHPFGKVLFSTYVQKFN-KFNKSSLRVLIVTDRFVAKLENKKFKLLKEPI 906

Human   942 EYSALKGVSTSNLSDGILVIHVSPED----------SKQKGDAVLQCGHVFEAVTKLVMLVKKEN 996
            ...::..:|....|:|:.||||...|          .::.|:.:   |.:.....|:.|......
 Worm   907 PLQSISRISVCAESNGLFVIHVGDNDIVGCAKNTKNEERVGEMI---GTLLAHYDKITMRRSPVL 968

Human   997 IVNVVQGSLQFFISPGKEGTI-VFDTGLEE--QVYKNKNG--------QLT 1036
            |.:.|..:|     .||..|| |||.....  .|:| |||        |||
 Worm   969 IQSAVVCTL-----GGKTRTIRVFDAENNNVPPVFK-KNGNDVDLICHQLT 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1H	XP_011536525.1	MYSc	8..711	CDD:214580	331/717 (46%)
		MYSc_Myo1	26..700	CDD:276829	319/692 (46%)
		Myosin_TH1	856..1019	CDD:283635	46/193 (24%)
hum-5	NP_497809.1	MYSc	6..699	CDD:214580	332/721 (46%)
		MYSc_Myo1	26..687	CDD:276829	319/692 (46%)
		Myosin_TH1	808..986	CDD:283635	46/192 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720