DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRD1 and CG11318

DIOPT Version :9

Sequence 1:	NP_001317426.1	Gene:	ADGRD1 / 283383	HGNCID:	19893	Length:	906	Species:	Homo sapiens
Sequence 2:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster

Alignment Length:	904	Identity:	185/904 - (20%)
Similarity:	318/904 - (35%)	Gaps:	258/904 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    75 RNATFVYSNDSAYSNLSATVDIVEGKVNKGIYLKEEKGVTLLYYGRYNSSCISKPEQCGPEGVTF 139
            ||.||.|. |....|.|                 :|...|.|.|      |.|.  .|.||....
  Fly    32 RNGTFQYC-DGEERNSS-----------------DELMQTHLVY------CTSM--FCEPEEFQH 70

Human   140 SFF------------WKTQ--GEQSRPIPSAYGGQVISNGFKVCSSGGRGSVELYTRDNSMTWEA 190
            .:.            ||..  ||::    :.:...::.||..|       :.|...:||...||:
  Fly    71 DYITRNHDQTPHQNKWKRARIGERA----TLHDVCLLRNGMPV-------TRECRVKDNRANWES 124

Human   191 SFSPPGPYWTHVLFTWKSKEGLKVYVNGTLS------------TSDPSGK-----VSRD-YGESN 237
            :     .:|..|:...:.:|..   ::|.|:            |:|..|:     :.|: :.:..
  Fly   125 T-----EHWDPVVCLRRFREHT---ISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRG 181

Human   238 VNLVIGSEQDQAKCYENGAFDEFIIWERALTPDEIAM---YFTAAI--GKHALLSSTLPSLFMTS 297
            .||:                           |.::.|   .|.|.:  .|.|.:|..|     .|
  Fly   182 GNLL---------------------------PADVHMTGQMFGALMQQDKDATVSVDL-----VS 214

Human   298 TASPVMPTDAYHPIITNLTEERKTFQSPGVILSYLQNVSLSLPSKSLSEQTALNLTKTFLKAVGE 362
            ....:|..|:.   :..|:.:.....|   :||..::...:||.:.:.:...           |:
  Fly   215 VCKEIMSCDSK---VLRLSAQLNATNS---LLSQFESYMDALPEQLVPKDRC-----------GK 262

Human   363 ILLLPGWIALSEDSAVVLSLIDTID----TVMGHVSSNLHGSTPQVTVEGSSAMAEFSVAKILPK 423
            ::..|    .|:::....:.::|.:    .|...::.|:.........:..:.:|.||......|
  Fly   263 VVAKP----TSDEAETATTGVETYNFSDIGVQALITGNISVFFANPECDRITGLAIFSAPGDQRK 323

Human   424 TVNSSH-YRFPAHGQSFIQIPHEAFHRHAWSTVVGLLYHSMHYYLNNIW-----PAHTKIAEAMH 482
            |..|.. |||....:...::..|:            ...:..:...|:|     ...|.:...::
  Fly   324 TSASGFWYRFIRFSEDLAKVKEES------------NLETAAFLPENLWRQVKSRGATYLIFKVY 376

Human   483 HQDCLLFAT---------SHLISLEVSPPPTLSQNLSGSPLITVHLKHRLTRKQHSEATNSSNRV 538
            ..|.|...|         |.:||:.:   |.|..|....||..: |::...|...|:|
  Fly   377 AHDALFVETSLQRTRKPRSKVISISI---PGLRSNYLSLPLPFL-LRNENLRNPDSKA------- 430

Human   539 FVYCAFLDFSSGEGVWSNHGCALTRGNLTYS----------VCRCTHLTNFAIL----------- 582
                  ....||.|.| |:....|.|..|.|          .|...|||.||.|
  Fly   431 ------FSIGSGCGYW-NYETWSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLG 488

Human   583 --MQVVPLELARGHQVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVL 645
              :.:.|:     ::..|..||.||||||:|.::...:|.|:..|..:..:.:..:|..|:..:
  Fly   489 EEILITPI-----NEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCL- 547

Human   646 VAQVLLLISFRLEP---------GTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSED 701
              |::|.:....:.         .|..|..:...:.|..|..|:|||:.....:...:.|.|.|
  Fly   548 --QMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIE- 609

Human   702 SKHRYYYG---MGWGFPLLICIISLSFAMDSYGTS--------NNCWLSLASGAIWAFVAPALFV 755
            ...||...   :.|..||:..::......|||..|        ..|:.| ..|.|:..|.|...:
  Fly   610 RPPRYILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTDTGICYPS-GYGLIFGVVLPVTLI 673

Human   756 IVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAV---AVLLPILGTSWVFGVLAVNGCAV 817
            .|.|:.|.:.|...||...:.:  ||.:..  |:..|.:   .:|..:||.:|:||:.|.....|
  Fly   674 TVCNLVIFVYVFYSISHSLSQS--IHKNEK--KMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGV 734

Human   818 VFQYMFATLNSLQGLFIFLFHCLLNSEVRAAF--------------KHKTKVWSLTSSS 862
            .|.|:|....::||..:|::..||:|..|..:              |..|::.|:|:||
  Fly   735 AFSYLFCITATMQGFVMFIYFVLLDSTNRRLWVGLICPTKMELDVQKRTTELQSMTTSS 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRD1	NP_001317426.1	None
CG11318	NP_651842.3	GPS	437..475	CDD:280071	11/38 (29%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	66/258 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810