Protein Alignment ADGRD1 and Mayo

DIOPT Version :10

• Sequence 1: NP_001317426.1
• Gene: ADGRD1 / 283383
• HGNCID: 19893
• Length: 906
• Species: Homo sapiens
• Sequence 2: NP_651842.3
• Gene: Mayo / 43678
• FlyBaseID: FBgn0039818
• Length: 802
• Species: Drosophila melanogaster
• Alignment Length: 899
• Identity: 185/899 - (20%)
• Similarity: 317/899 - (35%)
• Gaps: 248/899 - (27%)

Human    75 RNATFVYSNDSAYSNLSATVDIVEGKVNKGIYLKEEKGVTLLYYGRYNSSCISKPEQCGPEGVTF 139
            ||.||.|. |....|.|                 :|...|.|.|      |.|.  .|.||....
  Fly    32 RNGTFQYC-DGEERNSS-----------------DELMQTHLVY------CTSM--FCEPEEFQH 70

Human   140 SFF------------WKTQ--GEQSRPIPSAYGGQVISNGFKVCSSGGRGSVELYTRDNSMTWEA 190
            .:.            ||..  ||::    :.:...::.||..|       :.|...:||...||:
  Fly    71 DYITRNHDQTPHQNKWKRARIGERA----TLHDVCLLRNGMPV-------TRECRVKDNRANWES 124

Human   191 SFSPPGPYWTHVLFTWKSKEGLKVYVNGTLS------------TSDPSGK-----VSRD-YGESN 237
            :     .:|..|:...:.:|..   ::|.|:            |:|..|:     :.|: :.:..
  Fly   125 T-----EHWDPVVCLRRFREHT---ISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRG 181

Human   238 VNLVIGSEQDQAKCYENGAFDEFIIWERALTPDEIAM---YFTAAI--GKHALLSSTLPSLFMTS 297
            .||:                           |.::.|   .|.|.:  .|.|.:|..|     .|
  Fly   182 GNLL---------------------------PADVHMTGQMFGALMQQDKDATVSVDL-----VS 214

Human   298 TASPVMPTDAYHPIITNLTEERKTFQSPGVILSYLQNVSLSLPSKSLSEQTALNLTKTFLKAVGE 362
            ....:|..|:.   :..|:.:.....|   :||..::...:||.:.:.:...           |:
  Fly   215 VCKEIMSCDSK---VLRLSAQLNATNS---LLSQFESYMDALPEQLVPKDRC-----------GK 262

Human   363 ILLLPGWIALSEDSAVVLSLIDTID----TVMGHVSSNLHGSTPQVTVEGSSAMAEFSVAKILPK 423
            ::..|    .|:::....:.::|.:    .|...::.|:.........:..:.:|.||......|
  Fly   263 VVAKP----TSDEAETATTGVETYNFSDIGVQALITGNISVFFANPECDRITGLAIFSAPGDQRK 323

Human   424 TVNSSH-YRFPAHGQSFIQIPHEA-------FHRHAWSTVV--GLLYHSMHYYLNNIWPAHTKIA 478
            |..|.. |||....:...::..|:       ...:.|..|.  |..|.....|.::.....|.:.
  Fly   324 TSASGFWYRFIRFSEDLAKVKEESNLETAAFLPENLWRQVKSRGATYLIFKVYAHDALFVETSLQ 388

Human   479 EAMHHQDCLLFATSHLISLEVSPPPTLSQNLSGSPLITVHLKHRLTRKQHSEATNSSNRVFVYCA 543
            .....:       |.:||:.:   |.|..|....||..: |::...|...|:|
  Fly   389 RTRKPR-------SKVISISI---PGLRSNYLSLPLPFL-LRNENLRNPDSKA------------ 430

Human   544 FLDFSSGEGVWSNHGCALTRGNLTYS----------VCRCTHLTNFAIL-------------MQV 585
             ....||.|.| |:....|.|..|.|          .|...|||.||.|             :.:
  Fly   431 -FSIGSGCGYW-NYETWSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILI 493

Human   586 VPLELARGHQVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVL 650
            .|:     ::..|..||.||||||:|.::...:|.|:..|..:..:.:..:|..|:..:   |::
  Fly   494 TPI-----NEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCL---QMM 550

Human   651 LLISFRLEP---------GTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRY 706
            |.:....:.         .|..|..:...:.|..|..|:|||:.....:...:.|.|.| ...||
  Fly   551 LFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIE-RPPRY 614

Human   707 YYG---MGWGFPLLICIISLSFAMDSYGTS--------NNCWLSLASGAIWAFVAPALFVIVVNI 760
            ...   :.|..||:..::......|||..|        ..|:.| ..|.|:..|.|...:.|.|:
  Fly   615 ILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTDTGICYPS-GYGLIFGVVLPVTLITVCNL 678

Human   761 GILIAVTRVISQISADNYKIHGDPSAFKLTAKAV---AVLLPILGTSWVFGVLAVNGCAVVFQYM 822
            .|.:.|...||...:.:  ||.:..  |:..|.:   .:|..:||.:|:||:.|.....|.|.|:
  Fly   679 VIFVYVFYSISHSLSQS--IHKNEK--KMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYL 739

Human   823 FATLNSLQGLFIFLFHCLLNSEVRAAF--------------KHKTKVWSLTSSS 862
            |....::||..:|::..||:|..|..:              |..|::.|:|:||
  Fly   740 FCITATMQGFVMFIYFVLLDSTNRRLWVGLICPTKMELDVQKRTTELQSMTTSS 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADGRD1	NP_001317426.1	Laminin_G_3	<170..273	CDD:463865	17/120 (14%)
		GPS	542..582	CDD:460350	15/49 (31%)
		7tmB2_GPR133	595..854	CDD:320384	72/295 (24%)
		TM helix 1	597..622	CDD:320384	11/24 (46%)
		TM helix 2	634..656	CDD:320384	4/21 (19%)
		TM helix 3	665..692	CDD:320384	6/26 (23%)
		TM helix 4	704..722	CDD:320384	5/20 (25%)
		TM helix 5	741..770	CDD:320384	8/28 (29%)
		TM helix 6	786..813	CDD:320384	9/29 (31%)
		TM helix 7	817..842	CDD:320384	8/24 (33%)
Mayo	NP_651842.3	7tmB2_Adhesion	498..766	CDD:320168	71/276 (26%)
		TM helix 1	500..525	CDD:320168	11/24 (46%)
		TM helix 2	535..557	CDD:320168	4/24 (17%)
		TM helix 3	574..600	CDD:320168	6/25 (24%)
		TM helix 4	615..635	CDD:320168	3/19 (16%)
		TM helix 5	659..688	CDD:320168	8/28 (29%)
		TM helix 6	704..730	CDD:320168	8/25 (32%)
		TM helix 7	734..759	CDD:320168	8/24 (33%)