DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPBWR2 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_005277.2	Gene:	NPBWR2 / 2832	HGNCID:	4530	Length:	333	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	339	Identity:	126/339 - (37%)
Similarity:	177/339 - (52%)	Gaps:	33/339 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     8 EPLDSRGSFSLPTMGANVSQDNGTGHNATFSEPLPFLYVLLPAVYSGICAVGLTGNTAVILVILR 72
            :|.:|.....|||....::..|.            |..:....:|..:|.:||.|||.||.|:||
  Fly    52 QPEESLYGTDLPTYQHCIATRNS------------FADLFTVVLYGFVCIIGLFGNTLVIYVVLR 104

Human    73 APKMKTVTNVFILNLAVADGLFTLVLPVNIAEHLLQYWPFGELLCKLVLAVDHYNIFSSIYFLAV 137
            ..||:||||::||||||||..|.:.:|..:....:..|.|||.:||..:.......|:|..||.:
  Fly   105 FSKMQTVTNIYILNLAVADECFLIGIPFLLYTMRICSWRFGEFMCKAYMVSTSITSFTSSIFLLI 169

Human   138 MSVDRYLVVLATVRSRHMPWRTYRGAKVASLCVWLGVTVLVLPFFSFAGVYSNELQVP-SCGLSF 201
            ||.|||:.|...:.|..  :||...|||.|...|....||:||...:|.....|..:. ||.:.
  Fly   170 MSADRYIAVCHPISSPR--YRTLHIAKVVSAIAWSTSAVLMLPVILYASTVEQEDGINYSCNIM- 231

Human   202 PWPEQVWFKASR----VYTLVLGFVLPVCTICVLYTDLLRRLRAVRLRSGAKALGK--ARRKVTV 260
             ||: .:.|.|.    :||..|||..|:|.|...|..::|:||:|..:.|.|:..|  |.||||.
  Fly   232 -WPD-AYKKHSGTTFILYTFFLGFATPLCFILSFYYLVIRKLRSVGPKPGTKSKEKRRAHRKVTR 294

Human   261 LVLVVLAVCLLCWTPFHLASVVAL------TTDLPQTPLVISMSYVITSLSYANSCLNPFLYAFL 319
            |||.|::|.:|||.| |..|.|||      ..||.:..::|.:  ::.:|.|:||.:||.|||||
  Fly   295 LVLTVISVYILCWLP-HWISQVALIHSNPAQRDLSRLEILIFL--LLGALVYSNSAVNPILYAFL 356

Human   320 DDNFRKNFRSILRC 333
            .:||||:|.....|
  Fly   357 SENFRKSFFKAFTC 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPBWR2	NP_005277.2	7tmA_NPBWR	46..327	CDD:320215	117/293 (40%)
		TM helix 1	47..73	CDD:320215	11/25 (44%)
		TM helix 2	80..106	CDD:320215	12/25 (48%)
		TM helix 3	117..147	CDD:320215	11/29 (38%)
		TM helix 4	161..183	CDD:320215	9/21 (43%)
		TM helix 5	209..238	CDD:320215	11/32 (34%)
		TM helix 6	253..283	CDD:320215	17/31 (55%)
		TM helix 7	295..320	CDD:320215	11/24 (46%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	117/287 (41%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	104/266 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010