DRSC/TRiP Functional Genomics Resources

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Protein Alignment NPBWR2 and npr-24

DIOPT Version :9

Sequence 1:NP_005277.2 Gene:NPBWR2 / 2832 HGNCID:4530 Length:333 Species:Homo sapiens
Sequence 2:NP_510833.3 Gene:npr-24 / 187897 WormBaseID:WBGene00020086 Length:373 Species:Caenorhabditis elegans


Alignment Length:339 Identity:91/339 - (26%)
Similarity:165/339 - (48%) Gaps:41/339 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    24 NVSQDNGTGHNATFSEPLPFLYVLLPAVYSGICAVGLTGNTAVILVILRAPKMKTVTNVFILNLA 88
            |.::.|       |:|.:..:..:....:.....:|:..|..|:..|:....|:|::|::|.|||
 Worm     4 NTNEQN-------FTEVIDPIKTVAHLTWCLTALIGIPANLFVLAAIVYFRDMRTISNIYIFNLA 61

Human    89 VADGLFTLVLPVNI-AEHLLQYWPFGELLCKLVLAVDHYNIFSSIYFLAVMSVDRYLVVLATVRS 152
            |||.||...:||:: |:.....|.:|.::|||.::.:..:.|:|..|:|::|.||||.|...::|
 Worm    62 VADLLFLCGIPVSLFAQSSHDGWIWGPIMCKLYISGNAVSQFASAVFIAILSFDRYLAVCRPIQS 126

Human   153 RHMPWRTYRGAKVASLCVWLGVTVLVLPFFSFAGVY----SNELQVPSCGLSFPWPEQVWFKASR 213
            :  .:||.:.|...|:..|:.|.:.:.|.|.|..:.    :.|.:..||.| |.....|...|:.
 Worm   127 K--SFRTTQAAFALSVAAWIMVILEMTPLFLFVKLIKSSSAGEARGGSCML-FVGNVTVLESATE 188

Human   214 V---------------------YTLVLGFVLPVCTICVLYTDLLRRL--RAVRLRSGAKALGKAR 255
            :                     ||..|.:::|:..:...|..::.::  |..::::...|..|..
 Worm   189 MNETLLNEIEQNMLASRRFFISYTFALSYLIPLVAVWYFYFKIILKMCQRKRQMQTKRTATKKRT 253

Human   256 RKVTVLVLVVLAVCLLCWTPFHLA--SVVALTTDLPQTPLVISMSYVITSLSYANSCLNPFLYAF 318
            .|||::.|.::.....||.||.:.  |:.|...:..:. |:...::...:|.|.||..|||||.|
 Worm   254 TKVTIMGLAIVISYTHCWLPFWIVQWSIEANLFEKSKY-LLFCCTHFAFALQYINSAANPFLYVF 317

Human   319 LDDNFRKNFRSILR 332
            |.|:|:||.:.:||
 Worm   318 LSDSFQKNIQKLLR 331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPBWR2NP_005277.2 7tmA_NPBWR 46..327 CDD:320215 84/310 (27%)
TM helix 1 47..73 CDD:320215 4/25 (16%)
TM helix 2 80..106 CDD:320215 13/26 (50%)
TM helix 3 117..147 CDD:320215 12/29 (41%)
TM helix 4 161..183 CDD:320215 5/21 (24%)
TM helix 5 209..238 CDD:320215 6/49 (12%)
TM helix 6 253..283 CDD:320215 10/31 (32%)
TM helix 7 295..320 CDD:320215 10/24 (42%)
npr-24NP_510833.3 7tm_GPCRs 25..326 CDD:391938 84/304 (28%)
TM helix 1 25..46 CDD:341315 4/20 (20%)
TM helix 2 53..80 CDD:341315 13/26 (50%)
TM helix 3 91..121 CDD:341315 12/29 (41%)
TM helix 4 133..155 CDD:341315 5/21 (24%)
TM helix 5 185..234 CDD:341315 6/48 (13%)
TM helix 6 251..281 CDD:341315 9/29 (31%)
TM helix 7 293..319 CDD:341315 10/25 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 134 1.000 Domainoid score I3439
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 156 1.000 Inparanoid score I3303
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1011272at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X22
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.070

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