DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDH20 and CadN2

DIOPT Version :9

Sequence 1:	NP_114097.2	Gene:	CDH20 / 28316	HGNCID:	1760	Length:	801	Species:	Homo sapiens
Sequence 2:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster

Alignment Length:	898	Identity:	231/898 - (25%)
Similarity:	371/898 - (41%)	Gaps:	233/898 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     3 TSGRMSNA---KNWLGLGMSLYFWGLMDLTTTVLSDTPTPQGELEAL----------------LS 48
            |.|.:.||   :|..|:   :|....:|..|     .|..:..|||.                ::
  Fly    74 TGGNIGNAFAVQNTTGV---IYVASPLDYET-----RPRYELRLEATRNRKNNYTTVVINVRDVN 130

Human    49 DKPQSHQR-TKRSWVWNQFFVLEEYTGTDP---LYVGKLHSDMDRGDGSIKYILSGEG------A 103
            |.|....| |.|:.      :.||.....|   |.|.....|:|| ..:|.|.|:|:|      |
  Fly   131 DNPPVFDRQTYRTQ------ITEEDDRNLPKRILQVTATDGDVDR-PINIVYFLTGQGIDPDNPA 188

Human   104 GIVFTIDDTTGDIHAIQRLDREE---RAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKF 165
            ...|.|:.|||||..::.|||::   |.|:.....|.| ..|..:...::..:.::|||||.|:|
  Fly   189 NSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQD-EGGEGLVGYADIQVNLKDINDNAPQF 252

Human   166 LDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQ-------GQPYFSVDSKTGVI 223
            ..|.|...|.|....|:||:.::|.|.|||....:|:::|||.:       |.|.|.::.:||:|
  Fly   253 PQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLI 317

Human   224 RTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLES-- 286
            :||:..:|||....|.:.:.|.|.    |||.||.|.:|.:.|:||.||:|.:..:...|.|:
  Fly   318 KTAVCCLDRERTPDYSIQVVAMDG----GGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNG 378

Human   287 -----APISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFE-- 344
                 .||.:    |..:|.||....:.|.....|.|||.|.:..:.: ..|.:.:.:||.:|
  Fly   379 TYIPETPILT----VTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGD-GTGSLKIIQPLDYEDP 438

Human   345 -SKKSYTLKVE---------GANPHLEMRFLNLGPFQDTTTVHISVEDV-DEPPVFEPGFYFVEV 398
             ....:..:::         |.:....:.:         :.|.:.:.|: |..|.|:.....|.:
  Fly   439 LQSSGFRFRIQVNDKGDDGPGGSDKYHVAY---------SWVVVKLRDINDNVPKFDREHIEVSI 494

Human   399 PEDVAIGTTIQIISAKDPDVTNNS-IRYSIDRSSDPGRFFYVDITTGALMTARPLDREEFSWHNI 462
            .||..:||.::...|.|.|...:| :.|.|.||::..|.|.:. ..||:...||||||....|:|
  Fly   495 YEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAIS-DRGAVSIQRPLDRETQDRHHI 558

Human   463 TVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQDD--PRN 525
            .:||::..:|::..:..:|:.|.|||||||.|.:.|:..:.||. :|:.|..|:|.|.||  ..|
  Fly   559 QILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENV-SGKKILEVAAKDPDDRLRGN 622

Human   526 GQHFYYSLAPEAAN--NPNFTI----RDNQDNTARILTRRSGFRQQEQSVFHLPILIADSGQPVL 584
            |..|.:.|.|.|::  ...|.:    |.:.:|...|::....|.::.|..:.:||.|.|:|.|.:
  Fly   623 GGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAM 687

Human   585 SSTGTLTIQVCSCDDDGHVMSCSPEAYMLPVSLSRGALIAILACIFVLLVLVLLILSMRRHRKQP 649
            :.|.|||:.:...:|:          .|.|.|.|                 ||:.....:.:..|
  Fly   688 TGTSTLTVTIGDVNDN----------KMQPGSKS-----------------VLVYNYQGQSQDTP 725

Human   650 ----YIIDDEENIHENIVRYDDEGGGEEDTEAFDIAAMWNPREAQ--------------AGAAPK 696
                |:.|                  .:|.:..|....|..:|.|              ||
  Fly   726 IGRVYVND------------------PDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAG---- 768

Human   697 TRQDMLPEIESLSRYVPQTCAVNSTVHSYVLAKLYEADMDLWAPPFDSLQTYMFEGDGSVAGSLS 761
            ||:         .||             .:..|:|:.:                .|...:..:||
  Fly   769 TRR---------GRY-------------QLRFKVYDRE----------------HGQEDIPANLS 795

Human   762 -SLQSATSDSEQSF-----------DFLTDWGP-----------RFR-KLAEL 790
             :::..|:::.|..           ||:..|.|           ||| |||||
  Fly   796 VTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAEL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDH20	NP_114097.2	CA	85..163	CDD:214520	29/86 (34%)
		Cadherin_repeat	169..270	CDD:206637	38/107 (36%)
		Cadherin_repeat	278..385	CDD:206637	21/126 (17%)
		Cadherin_repeat	394..490	CDD:206637	33/96 (34%)
		Cadherin_repeat	498..595	CDD:206637	32/104 (31%)
		Cadherin_C	643..794	CDD:307269	33/190 (17%)
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	13/65 (20%)
		Cadherin_repeat	140..248	CDD:206637	34/115 (30%)
		Cadherin_repeat	256..359	CDD:206637	37/106 (35%)
		Cadherin_repeat	379..481	CDD:206637	19/115 (17%)
		Cadherin_repeat	489..586	CDD:206637	33/97 (34%)
		Cadherin_repeat	594..703	CDD:206637	32/109 (29%)
		Cadherin_repeat	724..801	CDD:206637	19/136 (14%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010