DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSNK2A3 and cka1

DIOPT Version :9

Sequence 1:	NP_001243615.1	Gene:	CSNK2A3 / 283106	HGNCID:	2458	Length:	391	Species:	Homo sapiens
Sequence 2:	NP_593642.1	Gene:	cka1 / 2541972	PomBaseID:	SPAC23C11.11	Length:	332	Species:	Schizosaccharomyces pombe

Alignment Length:	323	Identity:	213/323 - (65%)
Similarity:	268/323 - (82%)	Gaps:	0/323 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     2 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV 66
            :.||.|.:|||..||...||||||||:....:|.||:|:::||:||||||||||.:|:.||.|.:
pombe     6 AAPVVSVSRVYAHVNEEMPREYWDYENMQEVFGYQDNYEIIRKVGRGKYSEVFEGLNVLNNSKCI 70

Human    67 VKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY 131
            :|:|||||.||||||||||:||.||||||:|.|||:||.|:||:|:||.|:|.||:.||.||:||
pombe    71 IKVLKPVKYKKIKREIKILQNLAGGPNIISLLDIVRDPESKTPSLIFEFVDNIDFRTLYPTLSDY 135

Human   132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 196
            |||:|.||:|||||:|||.||||||||||||||||:.|||||||||||||||.|.||||||||||
pombe   136 DIRYYSYELLKALDFCHSRGIMHRDVKPHNVMIDHKKRKLRLIDWGLAEFYHAGMEYNVRVASRY 200

Human   197 FKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYDQLVRIAKFLGTEDLYGYIDKY 261
            |||||||||::.||||||:|..|.|.|::||:|:.||.|||||||||:|||.|||::|:.|:.||
pombe   201 FKGPELLVDFREYDYSLDIWSFGVMFAALIFKKDTFFRGRDNYDQLVKIAKVLGTDELFAYVQKY 265

Human   262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
            .|.||.::::|||::.::.|..||:.:|:.|.:.||:|.|::|||||||.|||.:|||.||||
pombe   266 QIVLDRQYDNILGQYPKRDWYSFVNRDNRSLANDEAIDLLNRLLRYDHQERLTCQEAMAHPYF 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSNK2A3	NP_001243615.1	STKc_CK2_alpha	20..325	CDD:271034	205/305 (67%)
		Pkinase	39..324	CDD:278497	192/284 (68%)
		PE_PPE_C	332..>389	CDD:289267
cka1	NP_593642.1	STKc_CK2_alpha	24..329	CDD:271034	205/305 (67%)
cka1	NP_593642.1	S_TKc	43..328	CDD:214567	192/284 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	429	1.000	Domainoid score	I94
eggNOG	1	0.900	-	-		E1_KOG0668
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	469	1.000	Inparanoid score	I325
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000968
OrthoInspector	1	1.000	-	-		otm53850
orthoMCL	1	0.900	-	-		OOG6_100821
Panther	1	1.100	-	-	O	PTHR24054
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.860