DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPBWR1 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_005276.2	Gene:	NPBWR1 / 2831	HGNCID:	4522	Length:	328	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	110/329 - (33%)
Similarity:	178/329 - (54%)	Gaps:	32/329 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    24 SNASTLAPLPAPLAVAVP------------------VVYAVICAVGLAGNSAVLYVLLRAPRMKT 70
            |.:||:.|..:.....:|                  |:|..:|.:||.||:.|:||:||..:|:|
  Fly    46 SGSSTIQPEESLYGTDLPTYQHCIATRNSFADLFTVVLYGFVCIIGLFGNTLVIYVVLRFSKMQT 110

Human    71 VTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRY 135
            |||::|||||:|||.|.:.:|..:....:..|.|||.|||..:......:|:|..||.:||||||
  Fly   111 VTNIYILNLAVADECFLIGIPFLLYTMRICSWRFGEFMCKAYMVSTSITSFTSSIFLLIMSADRY 175

Human   136 LVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFA-RLDDEQG-RRQCVLVFPQPEAF 198
            :.|.....|.|.  ||...|:.||...|....:::||..::| .::.|.| ...|.:::  |:|:
  Fly   176 IAVCHPISSPRY--RTLHIAKVVSAIAWSTSAVLMLPVILYASTVEQEDGINYSCNIMW--PDAY 236

Human   199 WWRASR---LYTLVLGFAIPVSTICVLYTTLLCRLHAM--RLDSHAKALERAKKRVTFLVVAILA 258
            ...:..   |||..||||.|:..|...|..::.:|.::  :..:.:|...||.::||.||:.:::
  Fly   237 KKHSGTTFILYTFFLGFATPLCFILSFYYLVIRKLRSVGPKPGTKSKEKRRAHRKVTRLVLTVIS 301

Human   259 VCLLCWTPYHLSTVVALTTDLPQ---TPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQ 320
            |.:|||.|:.:|.|..:.::..|   :.|.|.|...:.:|.|:||.:||.|||||..:||::..:
  Fly   302 VYILCWLPHWISQVALIHSNPAQRDLSRLEILIFLLLGALVYSNSAVNPILYAFLSENFRKSFFK 366

Human   321 LITC 324
            ..||
  Fly   367 AFTC 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPBWR1	NP_005276.2	7tmA_NPBWR	47..318	CDD:320215	101/280 (36%)
		TM helix 2	72..98	CDD:320215	12/25 (48%)
		TM helix 3	109..139	CDD:320215	12/29 (41%)
		TM helix 4	153..175	CDD:320215	6/21 (29%)
		TM helix 5	200..229	CDD:320215	10/31 (32%)
		TM helix 6	244..274	CDD:320215	13/29 (45%)
		TM helix 7	286..311	CDD:320215	12/24 (50%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	101/283 (36%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	91/262 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3389
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960