DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OR4C13 and htr7

DIOPT Version :9

Sequence 1:	NP_001001955.2	Gene:	OR4C13 / 283092	HGNCID:	15169	Length:	309	Species:	Homo sapiens
Sequence 2:	XP_031762460.1	Gene:	htr7 / 100494876	XenbaseID:	XB-GENE-1013674	Length:	440	Species:	Xenopus tropicalis

Alignment Length:	389	Identity:	69/389 - (17%)
Similarity:	128/389 - (32%)	Gaps:	129/389 - (33%)

- Green bases have known domain annotations that are detailed below.

Human     3 NRNNVTEFILLGLTENPKMQKIIFVVFSVIYINAMIGNVLIVVTITASPSLRSPMYFFLAYLSFI 67
            |.....|.::|......|:  :|..:.|:|.:..:.||.|:|:::.....||.|..:.:..|:..
Frog    61 NDTQCGELMILNYGHIEKL--VIGAILSLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALA 123

Human    68 DACYSSVNTPKLITDSLYENKTILFNGCMTQVFGEHFFRGV-----------EVILLTVMAYDHY 121
            |...:....|       :.:.|.|..|  ..:|| |.|..|           .::.|.|::.|.|
Frog   124 DLSVAIAVMP-------FVSVTDLIGG--EWIFG-HVFCNVFIAMDVMCCTASIMTLCVISIDRY 178

Human   122 VAICKPLHYTTVMKQHVCSLLVGVSWVGGFLHATIQILFICQLPFCG--PNVIDHFMCDLYTLIN 184
            :.|.:||.|.........:.::...|:   |.|:|.:     .|..|  .||.|..:|
Frog   179 LGITRPLTYPVRQNGRCMAKMILCVWL---LSASITL-----PPLFGWAQNVNDDKVC------- 228

Human   185 LACTNTHTLGLFIAANSGFICLLNCLLLLVSCVVILY---------------------------- 221
                       .|:.:.|:......:...:...|:|:
Frog   229 -----------LISQDFGYTIYSTAVAFYIPMSVMLFMYYRIFKAAKRSAAKHKFTGLPRPEESE 282

Human   222 -------SLKTH--------------------SLEARHEALSTCVSHITVVILSFIPCIFVYM-- 257
                   ::|||                    |:..|.:..:|.:.   :::.:|..|...:.
Frog   283 GMISANGNVKTHKESEECTNLSKLLRNDRKNISIFKREQKAATTLG---IIVGAFTICWLPFFLL 344

Human   258 ---RP----------PATLPIDKAVAVFYTMITSMLNPLIYTLRNAQMKNAIRKL--CSRKAIS 306
               ||          |..|   :...::.....|::||.||...|..::...|.|  |..:.|:
Frog   345 STARPFICGTECSCIPLWL---ERTFLWLGYANSLINPFIYAFFNRDLRTTYRNLLQCRYRNIN 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OR4C13	NP_001001955.2	7tm_4	29..303	CDD:304433	63/358 (18%)
OR4C13	NP_001001955.2	7tm_1	39..285	CDD:278431	55/328 (17%)
htr7	XP_031762460.1	7tmA_5-HT7	80..393	CDD:320452	61/354 (17%)
		TM helix 1	81..105	CDD:320452	7/23 (30%)
		TM helix 2	114..136	CDD:320452	3/28 (11%)
		TM helix 3	153..175	CDD:320452	3/21 (14%)
		TM helix 4	198..214	CDD:320452	4/23 (17%)
		TM helix 5	234..257	CDD:320452	3/22 (14%)
		TM helix 6	324..346	CDD:320452	3/24 (13%)
		TM helix 7	361..386	CDD:320452	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910