DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OR4C13 and drd1

DIOPT Version :9

Sequence 1:	NP_001001955.2	Gene:	OR4C13 / 283092	HGNCID:	15169	Length:	309	Species:	Homo sapiens
Sequence 2:	XP_017947694.2	Gene:	drd1 / 100485463	XenbaseID:	XB-GENE-6035431	Length:	451	Species:	Xenopus tropicalis

Alignment Length:	369	Identity:	78/369 - (21%)
Similarity:	132/369 - (35%)	Gaps:	89/369 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     3 NRNNVTEFILLGLTENPKMQKIIFVVF-SVIYINAMIGNVLIVVTITASPSLRSPM-YFFLAYLS 65
            |..::.|.:|  |.|.....:::...| ||:.::.::||.|:...:.....|||.: .||:..|:
Frog     4 NITSMDEDVL--LAERDSSFRVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLA 66

Human    66 FIDACYSSVNTP-KLITD-------SLYENKTILFN-GCMTQVFGEHFFRGVEVILLTVMAYDHY 121
            ..|...:.:..| |.:.:       ..:.|..:.|: .|.|          ..::.|.|::.|.|
Frog    67 VSDLLVAVLVMPWKAVAEIAGFWPFGTFCNIWVAFDIMCST----------ASILNLCVISVDRY 121

Human   122 VAICKPLHYTTVMKQHVCSLLVGVSWVGGFLHATIQILFI-CQLPFCGPNVIDHFMCDLYTLINL 185
            .||..|..|...|...|..:::.|:|.     .:|.|.|| .||.:........|..:: ||...
Frog   122 WAISSPFRYERKMTPKVAFIMISVAWT-----LSILISFIPVQLNWHKAKTTSFFDLNI-TLHGR 180

Human   186 ACTN-THTLGLFIAANSGFICLLNCLLLLVSCVVILY---------------------------- 221
            ...| ..:|....|.:|..|.....:.:::.....:|
Frog   181 TMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAAKQIRRISALERAAVHAKNCQNSTG 245

Human   222 ------------SLKTHSLEARHEALSTCVSHITVVILSFIP-----CIFVYMRPPATLPIDKA- 268
                        |||| |.:...:.|.|....:.|.:..::|     ||..:..|..|....:.
Frog   246 NRNSLDCQQPESSLKT-SFKRETKVLKTLSVIMGVFVCCWLPFFILNCIVPFCDPSLTTSGTEPF 309

Human   269 --------VAVFYTMITSMLNPLIYTLRNAQMKNAIRKL--CSR 302
                    |.|::....|.|||:||.. ||..:.|...|  |.|
Frog   310 CISSTTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSNLLGCYR 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OR4C13	NP_001001955.2	7tm_4	29..303	CDD:304433	73/343 (21%)
OR4C13	NP_001001955.2	7tm_1	39..285	CDD:278431	62/311 (20%)
drd1	XP_017947694.2	7tmA_D1A_dopamine_R	22..344	CDD:320443	69/339 (20%)
		TM helix 1	25..49	CDD:320443	6/23 (26%)
		TM helix 2	59..81	CDD:320443	5/21 (24%)
		TM helix 3	96..118	CDD:320443	6/31 (19%)
		TM helix 4	141..157	CDD:320443	5/20 (25%)
		TM helix 5	191..214	CDD:320443	3/22 (14%)
		TM helix 6	270..292	CDD:320443	4/21 (19%)
		TM helix 7	313..338	CDD:320443	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910