Protein Alignment GPR6 and 5-HT1B

DIOPT Version :9

• Sequence 1: NP_001273028.1
• Gene: GPR6 / 2830
• HGNCID: 4515
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 100/539 - (18%)
• Similarity: 147/539 - (27%)
• Gaps: 256/539 - (47%)

Human    86 AVNPWDVLLCVSGTVIAG--------ENALVVALIASTPALRTPMFVLVGSLATADLLAGC---- 138
            ||..|.::..::..|:.|        .|..|:|.|.....|:.....||.|||.|||...|
  Fly    81 AVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMP 145

Human   139 -GLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHL 202
             |.:......:::..|...:.| ...|....||:..|:||..|||.::.| :.|.:.||...|.|
  Fly   146 LGAVYEISNGWILGPELCDIWT-SCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFL 208

Human   203 LLAATWTVSLGLGLLPVLGW------------NCLAER-------AAC----------------- 231
            ::...|..:|.:.|.|..||            :|:..:       |.|
  Fly   209 MIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKI 273

Human   232 --------------------------SVVRPLARSH----------------------------- 241
                                      |.||.|.:..
  Fly   274 YIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQR 338

Human   242 --------------------------VALLSAAFFMVFGIML-----------------HLYVRI 263
                                      ||...||..:.|..:.                 |....:
  Fly   339 RTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTEL 403

Human   264 CQVV-----WR--HAHQI---------ALQQH----------------------CL--------- 281
            ..|.     :|  :|::|         |.|.|                      ||
  Fly   404 TTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKA 468

Human   282 ------------------------------------------APPH--LA---------ATRKGV 293
                                                      |.||  ||         ..||..
  Fly   469 LSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAA 533

Human   294 GTLAVVLGTFGASWLPFAIYCVVGS-HEDPAVYTYAT---LLPATYNSMINPIIYAFRNQEIQRA 354
            .|||::.|.|...||||.:..:..| .::..::|...   |....:||.:||:||...|.|.:||
  Fly   534 QTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRA 598

Human   355 LWLLLCGCFQSKVPFRSRS 373
            ...:|   |..|...|:||
  Fly   599 FKRIL---FGRKAAARARS 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR6	NP_001273028.1	7tmA_GPR6	88..355	CDD:320628	91/517 (18%)
		TM helix 1	89..115	CDD:320628	7/33 (21%)
		TM helix 2	122..147	CDD:320628	10/29 (34%)
		TM helix 3	156..186	CDD:320628	10/29 (34%)
		TM helix 4	198..218	CDD:320628	5/19 (26%)
		TM helix 5	237..266	CDD:320628	7/100 (7%)
		TM helix 6	287..317	CDD:320628	12/38 (32%)
		TM helix 7	323..348	CDD:320628	8/27 (30%)
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	41/182 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910