DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF311 and E430018J23Rik

DIOPT Version :9

Sequence 1:	XP_005249076.1	Gene:	ZNF311 / 282890	HGNCID:	13847	Length:	699	Species:	Homo sapiens
Sequence 2:	NP_932128.2	Gene:	E430018J23Rik / 101604	MGIID:	2141981	Length:	461	Species:	Mus musculus

Alignment Length:	537	Identity:	180/537 - (33%)
Similarity:	248/537 - (46%)	Gaps:	135/537 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    62 YPAFTKDGSQGNLPQADITLMSQAQDSRSILFQESVTFEDVAVNFTNREWQCLTYAQRHLYKDVM 126
            :|||.|.|                          :|:|.||||.|:..||:||..|||.||::||
Mouse    13 WPAFLKPG--------------------------TVSFADVAVYFSPEEWRCLRPAQRTLYREVM 51

Human   127 LENYGNMVSLGFPFPKPPLISHLEREVDPCVQDPQDRESLSCSYPVSADKMWPENEKASSQQEIF 191
            .|.||.:.||.....||.||                     |         |.|.|     .|::
Mouse    52 RETYGLLASLEVGGDKPALI---------------------C---------WVEEE-----SEVW 81

Human   192 ENGEAYWMKFNSLLKVDSRDPKVREVCVQDVKLENQWETSIREKLREEKEGS---EEVTCKKGKN 253
            ..|              :::|:| .:|          .|.:....|.||||.   ||....|
Mouse    82 GPG--------------AQEPEV-AMC----------RTEVHSDCRHEKEGKRPREETKATK--- 118

Human   254 QKVLSKNL-----NPNSKHSQCNKVLIAQKLHECARCGKNFSWHSDLILHEQIHSGEKPHVCNEC 313
             |:||...     .|:.....||..|:.:...:         .|..:.:|..|...::.|.|:.|
Mouse   119 -KILSPEAGPMEPRPSFASPSCNLELLFKNSQQ---------GHPTVAVHNPILKADQRHGCHVC 173

Human   314 GKAFKTRNQLSMHRIIHTGEKPFNCTQCGKAFNSRSALCRHKKTHSGEKPHECRDCGKAFKTRNR 378
            ||:|..:::|..|...|||||||.|..|.|.|...|:|..|:..|.||:||:|.||||:|..|:.
Mouse   174 GKSFAHQSKLVEHLYTHTGEKPFQCPDCDKYFGRASSLSMHRAIHRGERPHQCPDCGKSFTQRST 238

Human   379 LCMHQLIHTGEKPYKCNCCGKAFQFKHSLTIHGRIHTGEKPYECEECGKAFSGSSDLTKHIRIHT 443
            |..|...||||||:.|..|.|:|....||:.|..||.||:|:.|.:||:||:..|.|..|:|:||
Mouse   239 LVAHMYTHTGEKPFHCPDCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLIAHLRVHT 303

Human   444 GERPYECSKCGRAFSRSSDLSKHKRIHTREKHYGCPQCGKDFSIKAELTKHRRIHTEEKRYRCEE 508
            ||:||.|:.|||.||:||.|.:|:|:                           :|:....:.|..
Mouse   304 GEKPYCCADCGRCFSQSSGLREHQRV---------------------------VHSGVTPFTCTH 341

Human   509 CGKAFRHNCKRRAHEREHTGEKPYQCRDCGKTFQDKHCLTIHQRIHTGEKPYKCLECGKAFSGKS 573
            ||:||......:.|.|.|||||||.|.|||:.|:....:..|:|.|:||:||.|.:||:.|..||
Mouse   342 CGRAFARAAYLQCHMRTHTGEKPYSCPDCGRCFRQSSDMAAHRRTHSGERPYPCPQCGRRFPTKS 406

Human   574 NLTNHRRIH-TGEKPHK 589
            .:|.|:.:| .|.|.||
Mouse   407 AVTKHQWVHRPGAKGHK 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF311	XP_005249076.1	KRAB	97..157	CDD:214630	27/59 (46%)
		KRAB	97..136	CDD:279668	21/38 (55%)
		C2H2 Zn finger	282..302	CDD:275368	2/19 (11%)
		zf-H2C2_2	294..319	CDD:290200	8/24 (33%)
		COG5048	306..>633	CDD:227381	120/285 (42%)
		C2H2 Zn finger	310..330	CDD:275368	7/19 (37%)
		zf-H2C2_2	323..347	CDD:290200	13/23 (57%)
		C2H2 Zn finger	338..358	CDD:275368	7/19 (37%)
		zf-H2C2_2	353..375	CDD:290200	12/21 (57%)
		C2H2 Zn finger	366..386	CDD:275368	9/19 (47%)
		C2H2 Zn finger	394..414	CDD:275368	7/19 (37%)
		zf-C2H2	420..442	CDD:278523	9/21 (43%)
		C2H2 Zn finger	422..442	CDD:275368	9/19 (47%)
		zf-H2C2_2	434..459	CDD:290200	14/24 (58%)
		C2H2 Zn finger	450..470	CDD:275368	11/19 (58%)
		C2H2 Zn finger	478..498	CDD:275368	0/19 (0%)
		zf-H2C2_2	490..515	CDD:290200	6/24 (25%)
		C2H2 Zn finger	506..526	CDD:275368	7/19 (37%)
		zf-H2C2_2	520..541	CDD:290200	13/20 (65%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
		zf-H2C2_2	547..570	CDD:290200	10/22 (45%)
		C2H2 Zn finger	562..582	CDD:275368	8/19 (42%)
		zf-H2C2_2	574..599	CDD:290200	7/17 (41%)
		C2H2 Zn finger	590..610	CDD:275368	180/537 (34%)
		zf-H2C2_2	603..627	CDD:290200
		C2H2 Zn finger	618..638	CDD:275368
		zf-H2C2_2	634..653	CDD:290200
		C2H2 Zn finger	646..664	CDD:275368
E430018J23Rik	NP_932128.2	KRAB	22..81	CDD:214630	32/93 (34%)
		KRAB	22..61	CDD:279668	21/38 (55%)
		C2H2 Zn finger	170..190	CDD:275368	7/19 (37%)
		zf-H2C2_2	183..207	CDD:290200	13/23 (57%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		zf-H2C2_2	210..235	CDD:290200	13/24 (54%)
		COG5048	<223..383	CDD:227381	75/186 (40%)
		C2H2 Zn finger	226..246	CDD:275368	9/19 (47%)
		zf-H2C2_2	239..259	CDD:290200	10/19 (53%)
		C2H2 Zn finger	254..302	CDD:275368	21/47 (45%)
		zf-H2C2_2	298..319	CDD:290200	13/20 (65%)
		C2H2 Zn finger	310..331	CDD:275368	11/47 (23%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		zf-H2C2_2	351..376	CDD:290200	14/24 (58%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		zf-H2C2_2	383..402	CDD:290200	10/18 (56%)
		C2H2 Zn finger	395..415	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000449
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910