DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF311 and Gm14308

DIOPT Version :9

Sequence 1:	XP_005249076.1	Gene:	ZNF311 / 282890	HGNCID:	13847	Length:	699	Species:	Homo sapiens
Sequence 2:	NP_001092819.1	Gene:	Gm14308 / 100043381	MGIID:	3782921	Length:	498	Species:	Mus musculus

Alignment Length:	568	Identity:	247/568 - (43%)
Similarity:	316/568 - (55%)	Gaps:	84/568 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    97 VTFEDVAVNFTNREWQCLTYAQRHLYKDVMLENYGNMVSLGFPFPKPPLISHLEREVDPCVQDPQ 161
            ||::||.||||..||..|..:|:.|||.||||.|.|:.::|:.:.:..:..|.:      .....
Mouse     4 VTYDDVHVNFTQDEWALLDPSQKSLYKGVMLETYKNLTAIGYIWEEHTIEDHFQ------TSRSH 62

Human   162 DRESLSCSYPVSADKMWPENEKASSQQEIFENGEAYWMKFNSLLKVDSRDPKVREVCVQDVKLEN 226
            .|...|||              |....|..:.|:|:
Mouse    63 GRHERSCS--------------AEQPSEFIQCGKAF----------------------------- 84

Human   227 QWETSIREKLREEKEGSEEVTCKKGKNQKVLSKNLNPNSKHSQCNKVLIAQKLHECARCGKNFSW 291
                                ..:.|:.:..:..|               .:|.|:|.:|||:|..
Mouse    85 --------------------AYESGRQRHQIKHN---------------GEKHHDCNQCGKDFRT 114

Human   292 HSDLILHEQIHSGEKPHVCNECGKAFKTRNQLSMHRIIHTGEKPFNCTQCGKAFNSRSALCRHKK 356
            .:.|.:|::.|:||||:.|.:|||.|.....|.:|...|.|||.:.|.||||||..|..|..||:
Mouse   115 WNVLQIHKRTHTGEKPYDCKQCGKVFARSCHLQIHNRTHAGEKQYECNQCGKAFKRRINLQIHKR 179

Human   357 THSGEKPHECRDCGKAFKTRNRLCMHQLIHTGEKPYKCNCCGKAFQFKHSLTIHGRIHTGEKPYE 421
            ||:||||:||..|||||.:...|..|:..|||||||:|..|||||.....|.||.|.||||||||
Mouse   180 THTGEKPYECNQCGKAFASSGELQKHKRTHTGEKPYECKQCGKAFSQSSHLRIHKRTHTGEKPYE 244

Human   422 CEECGKAFSGSSDLTKHIRIHTGERPYECSKCGRAFSRSSDLSKHKRIHTREKHYGCPQCGKDFS 486
            |.:|||||:.|.||.||.|.||||:||||.:||:||:.||.|.||:|.||.:|.|.|.||||.|:
Mouse   245 CNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHSSHLHKHERTHTGDKPYECKQCGKAFA 309

Human   487 IKAELTKHRRIHTEEKRYRCEECGKAFRHNCKRRAHEREHTGEKPYQCRDCGKTFQDKHCLTIHQ 551
            :...|..|:|.||.:|.|.|::|||||......:.|:|.|||||||:|:.|||.|.....|.||:
Mouse   310 VIYTLQMHKRTHTGDKPYECKQCGKAFAVIYTLQMHKRTHTGEKPYKCKQCGKAFARSCHLRIHK 374

Human   552 RIHTGEKPYKCLECGKAFSGKSNLTNHRRIHTGEKPHKCEVCGMAFHHSSVLRQHKRIHTGEKPY 616
            |.|||||||:|.:|||||:..|.|..|.|.||||||::|..||.||....||:.|||.|||||||
Mouse   375 RTHTGEKPYECNQCGKAFAESSTLQIHNRTHTGEKPYECNQCGKAFITRRVLQIHKRTHTGEKPY 439

Human   617 TCSECGTSFRQGSALIGHKRVHTGEKPYECEECGKAFRVSSNLTGHKK 664
            .|::||.:|.:...|..|||.|||||||||..|||||..||:|..||:
Mouse   440 ECNQCGKAFARSCDLQKHKRTHTGEKPYECNHCGKAFAQSSSLRIHKR 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF311	XP_005249076.1	KRAB	97..157	CDD:214630	23/59 (39%)
		KRAB	97..136	CDD:279668	21/38 (55%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		zf-H2C2_2	294..319	CDD:290200	12/24 (50%)
		COG5048	306..>633	CDD:227381	180/326 (55%)
		C2H2 Zn finger	310..330	CDD:275368	7/19 (37%)
		zf-H2C2_2	323..347	CDD:290200	13/23 (57%)
		C2H2 Zn finger	338..358	CDD:275368	11/19 (58%)
		zf-H2C2_2	353..375	CDD:290200	15/21 (71%)
		C2H2 Zn finger	366..386	CDD:275368	8/19 (42%)
		C2H2 Zn finger	394..414	CDD:275368	10/19 (53%)
		zf-C2H2	420..442	CDD:278523	14/21 (67%)
		C2H2 Zn finger	422..442	CDD:275368	12/19 (63%)
		zf-H2C2_2	434..459	CDD:290200	17/24 (71%)
		C2H2 Zn finger	450..470	CDD:275368	11/19 (58%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		zf-H2C2_2	490..515	CDD:290200	13/24 (54%)
		C2H2 Zn finger	506..526	CDD:275368	8/19 (42%)
		zf-H2C2_2	520..541	CDD:290200	13/20 (65%)
		C2H2 Zn finger	534..554	CDD:275368	9/19 (47%)
		zf-H2C2_2	547..570	CDD:290200	16/22 (73%)
		C2H2 Zn finger	562..582	CDD:275368	10/19 (53%)
		zf-H2C2_2	574..599	CDD:290200	14/24 (58%)
		C2H2 Zn finger	590..610	CDD:275368	10/19 (53%)
		zf-H2C2_2	603..627	CDD:290200	15/23 (65%)
		C2H2 Zn finger	618..638	CDD:275368	8/19 (42%)
		zf-H2C2_2	634..653	CDD:290200	15/18 (83%)
		C2H2 Zn finger	646..664	CDD:275368	10/17 (59%)
Gm14308	NP_001092819.1	KRAB	3..44	CDD:396083	21/39 (54%)
		COG5048	74..486	CDD:227381	217/475 (46%)
		C2H2 Zn finger	79..97	CDD:275368	3/66 (5%)
		C2H2 Zn finger	105..125	CDD:275368	7/19 (37%)
		C2H2 Zn finger	133..153	CDD:275368	7/19 (37%)
		C2H2 Zn finger	161..181	CDD:275368	11/19 (58%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		C2H2 Zn finger	217..237	CDD:275368	10/19 (53%)
		C2H2 Zn finger	245..265	CDD:275368	12/19 (63%)
		C2H2 Zn finger	273..293	CDD:275368	11/19 (58%)
		C2H2 Zn finger	301..321	CDD:275368	9/19 (47%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..405	CDD:275368	10/19 (53%)
		C2H2 Zn finger	413..433	CDD:275368	10/19 (53%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		C2H2 Zn finger	469..488	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910