DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POC1B and MDV1

DIOPT Version :9

Sequence 1:	NP_758440.1	Gene:	POC1B / 282809	HGNCID:	30836	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_012423.1	Gene:	MDV1 / 853332	SGDID:	S000003648	Length:	714	Species:	Saccharomyces cerevisiae

Alignment Length:	349	Identity:	87/349 - (24%)
Similarity:	139/349 - (39%)	Gaps:	84/349 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    37 SWDTFLMLWNFKPHARAYRYVG-----HKDVVTSVQF-SPHGNLLASASRDRTVRLWIPDKRGKF 95
            |:.||..|  ::|..:    :|     |.|.:|.:.| :|.|.|..:...|.||::|...|:.|.
Yeast   376 SFPTFQQL--YEPGTK----IGSIMSTHDDFLTCLDFDAPFGTLCTAGYLDHTVKIWDLSKQNKI 434

Human    96 SEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLY--------------SLYRHT-- 144
            .|...|.|.:..:..:.|...|.|...|.::|:|::...:.||              |...||
Yeast   435 GELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNLAQQLYQETQNLTSPTNHIDSPCVHTFE 499

Human   145 -HWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF------VDFNPSGTCIA 202
             |.......|.|...:||.|:|:||:.||..:.:|:...  .:.|||.      ||.:.| |.:.
Yeast   500 AHTDEVTALSLDPSFLVSGSQDRTIRQWDLRSGKCLQTI--DLSFANVLTTSTNVDLSKS-TLLT 561

Human   203 SAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQ 267
            ......::..        ||.:..               .|.|.:.||.:::.||..|::|.||:
Yeast   562 QRNERPSIGA--------LQSFDA---------------ALATGTKDGVVRLWDLRSGKVIRTLK 603

Human   268 GHTGPVFTVSFSKGGELFASGGADTQVLLW--RTNFDELHCKGLTKRNLKRLHFDSPPHL-LDIY 329
            |||..:.::.|...  ...:|..|..|.:|  ||        ||    |.:.|..|.|.| ||::
Yeast   604 GHTDAITSLKFDSA--CLVTGSYDRTVRIWDLRT--------GL----LNKFHAYSAPVLSLDLF 654

Human   330 PRTPHPHEEKVETVEINPKLEVID 353
                  .|.....|...|.:::.|
Yeast   655 ------QENAAVVVADEPSVQIYD 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POC1B	NP_758440.1	WD40	10..298	CDD:238121	72/291 (25%)
		WD 1	16..55		5/17 (29%)
		WD40 repeat	21..58	CDD:293791	5/20 (25%)
		WD 2	58..99		15/46 (33%)
		WD40 repeat	63..100	CDD:293791	12/37 (32%)
		WD 3	101..139		10/51 (20%)
		WD40 repeat	106..142	CDD:293791	9/49 (18%)
		WD 4	142..181		14/41 (34%)
		WD40 repeat	147..182	CDD:293791	11/34 (32%)
		WD 5	183..223		8/45 (18%)
		WD40 repeat	190..225	CDD:293791	7/40 (18%)
		WD 6	226..265		8/38 (21%)
		WD40 repeat	231..267	CDD:293791	9/35 (26%)
		WD 7	268..307		10/40 (25%)
		WD40 repeat	273..299	CDD:293791	5/27 (19%)
MDV1	NP_012423.1	Mdv1	123..171	CDD:402923
		WD40	397..713	CDD:238121	81/322 (25%)
		WD40 repeat	402..439	CDD:293791	12/36 (33%)
		WD40 repeat	444..499	CDD:293791	11/54 (20%)
		WD40 repeat	506..539	CDD:293791	11/34 (32%)
		WD40 repeat	546..603	CDD:293791	15/80 (19%)
		WD40 repeat	648..683	CDD:293791	7/31 (23%)
		WD40 repeat	690..712	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910