DRSC/TRiP Functional Genomics Resources

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Protein Alignment POC1B and CDC40

DIOPT Version :9

Sequence 1:NP_758440.1 Gene:POC1B / 282809 HGNCID:30836 Length:478 Species:Homo sapiens
Sequence 2:NP_010652.3 Gene:CDC40 / 851968 SGDID:S000002772 Length:455 Species:Saccharomyces cerevisiae


Alignment Length:294 Identity:70/294 - (23%)
Similarity:133/294 - (45%) Gaps:32/294 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    56 YVGHKDVVTSVQFSPH-GNLLASASRDRTVRLWIPDKRGKFS---EFKAHTAPVRSVDFSADGQF 116
            |.||.:..|:::|.|. |:|:.|...|.|:::|  |....:.   :|:.|..|::::.|:.|.|.
Yeast   158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIW--DFYHDYECLRDFQGHNKPIKALRFTEDCQS 220

Human   117 LATASEDKSIKVWSMYRQRFLYSLYRHT--HWVRCAKFSPDGRLIVSCSEDKTIKIWD--TTNKQ 177
            ..::|.|:|:|:|.....:....|:.::  ..|.....:|. ..||..|..|.:...|  :.|:.
Yeast   221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH-EFIVGLSNSKILHYDDRVSENQG 284

Human   178 CVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN---KLLQHYQVHSGGVNCISFHPS 239
            .|..:...:.....:.:.|.|:...|:..|:||::|:.::|   |.:.....||  :..::.|||
Yeast   285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHS--MPFLNVHPS 347

Human   240 GNYLITASSDGTLKILDL-----LEGRLIYTLQGHTGPVFTVS--FSKGGELFASGGADTQVLLW 297
            .||....|.|..:....|     ...:.|:  :||:...:.:|  ||..|....||.:.:::..|
Yeast   348 QNYFCAQSMDNRIYSFSLKPKYKRHPKKIF--KGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410

Human   298 RTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPR 331
            ..|...|      ..|:| :..:.|...:|.:|:
Yeast   411 DWNTSRL------LNNIK-IPGNKPITQVDWHPQ 437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POC1BNP_758440.1 WD40 10..298 CDD:238121 62/259 (24%)
WD 1 16..55
WD40 repeat 21..58 CDD:293791 1/1 (100%)
WD 2 58..99 12/44 (27%)
WD40 repeat 63..100 CDD:293791 11/40 (28%)
WD 3 101..139 10/37 (27%)
WD40 repeat 106..142 CDD:293791 9/35 (26%)
WD 4 142..181 9/42 (21%)
WD40 repeat 147..182 CDD:293791 9/36 (25%)
WD 5 183..223 9/42 (21%)
WD40 repeat 190..225 CDD:293791 9/37 (24%)
WD 6 226..265 11/43 (26%)
WD40 repeat 231..267 CDD:293791 9/40 (23%)
WD 7 268..307 11/40 (28%)
WD40 repeat 273..299 CDD:293791 7/27 (26%)
CDC40NP_010652.3 WD40 154..408 CDD:238121 62/256 (24%)
WD40 repeat 166..204 CDD:293791 11/39 (28%)
WD40 repeat 210..247 CDD:293791 9/36 (25%)
WD40 repeat 252..290 CDD:293791 9/38 (24%)
WD40 repeat 297..332 CDD:293791 9/34 (26%)
WD40 repeat 339..378 CDD:293791 9/40 (23%)
WD40 repeat 386..422 CDD:293791 10/41 (24%)
WD40 repeat 429..453 CDD:293791 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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