Protein Alignment POC1B and CG10064

DIOPT Version :10

• Sequence 1: NP_758440.1
• Gene: POC1B / 282809
• HGNCID: 30836
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_648065.1
• Gene: CG10064 / 38761
• FlyBaseID: FBgn0035724
• Length: 742
• Species: Drosophila melanogaster
• Alignment Length: 405
• Identity: 83/405 - (20%)
• Similarity: 151/405 - (37%)
• Gaps: 55/405 - (13%)

Human    17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRD 81
            |..::..:....|...:...|....:.:|:........|.:.:......|:|:..|..:.|...|
  Fly   366 HTKSVYCITFPKNYSGVFATSGKECIRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWND 430

Human    82 RTVRLWIP-DKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM--YRQRFLYSLYRH 143
            ..:|.:.| ..|..::...||.....::..::.|:.:.|...:..::||.:  |||..:..|..|
  Fly   431 GIIRAFTPITGRLIYAIPNAHNKGCSALAVASSGRLIVTGGIEGQVRVWKIDPYRQDLVGVLKDH 495

Human   144 THWVRCAKFSPDGRLIVSCSEDKTIKIWD---TTNKQCVNNFSDSVGFANFVDFNPSGTCIASAG 205
            :..:.....:.....::|...|.:..|||   .|.||.|...:..:..:.|    |:|..:.:.|
  Fly   496 SGPITSLDINYLDTEVISACTDGSCVIWDIKRMTRKQVVTANTQFMSASYF----PTGVQVITCG 556

Human   206 SDQTVKVWDVRVNKLLQHYQV-HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGH 269
            ||..:..|.|....|::.... ....|||::.:.:|:|.||..||..:|:.|...|.::.....|
  Fly   557 SDGRIIYWMVYNGALIRELTASKKSSVNCLAINETGDYFITVGSDLQVKLWDYNSGAVVGIGSEH 621

Human   270 TGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPH 334
            ...|.:.::|....:|.:|..|..:::|                      |.|   .|.:.|...
  Fly   622 ASSVISCAYSPCMTMFVTGSTDGSLIIW----------------------DVP---RDFWGRPNP 661

Human   335 PHEEKVETVEINPKLEVIDLQISTPPVMDILSFDSTTTTETSGRTLPDKGEEACGYFL---NPSL 396
            |...|....:.:.|..:.|:....         :|.|..:|:      |||...|...   ...|
  Fly   662 PDVTKYSLPKTSSKTRMSDVPSRV---------NSGTNLKTT------KGENIDGLLKATPKDDL 711

Human   397 MSPECLPTTTKKKTE 411
            ...|| |...||.|:
  Fly   712 CCVEC-PPCAKKDTK 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POC1B	NP_758440.1	WD40	<5..300	CDD:441893	61/289 (21%)
		WD 1	16..55		4/37 (11%)
		WD40 repeat	21..58	CDD:293791	4/36 (11%)
		WD 2	58..99		8/41 (20%)
		WD40 repeat	63..100	CDD:293791	8/37 (22%)
		WD 3	101..139		8/39 (21%)
		WD40 repeat	106..142	CDD:293791	8/37 (22%)
		WD 4	142..181		10/41 (24%)
		WD40 repeat	147..182	CDD:293791	9/37 (24%)
		WD 5	183..223		9/39 (23%)
		WD40 repeat	190..225	CDD:293791	9/34 (26%)
		WD 6	226..265		12/39 (31%)
		WD40 repeat	231..267	CDD:293791	12/35 (34%)
		WD 7	268..307		7/38 (18%)
		WD40 repeat	273..299	CDD:293791	6/25 (24%)
CG10064	NP_648065.1	WD40	<59..482	CDD:441893	19/115 (17%)
		WD40 repeat	65..106	CDD:293791
		WD40 repeat	111..151	CDD:293791
		WD40 repeat	159..186	CDD:293791
		WD40	366..650	CDD:238121	61/309 (20%)
		WD40 repeat	370..407	CDD:293791	4/36 (11%)
		WD40 repeat	412..449	CDD:293791	8/36 (22%)
		WD40 repeat	456..494	CDD:293791	8/37 (22%)
		WD40 repeat	499..535	CDD:293791	8/35 (23%)
		WD40 repeat	541..576	CDD:293791	9/38 (24%)
		WD40 repeat	583..617	CDD:293791	12/33 (36%)
		WD40 repeat	625..651	CDD:293791	6/47 (13%)