DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POC1B and tup11

DIOPT Version :9

Sequence 1:	NP_758440.1	Gene:	POC1B / 282809	HGNCID:	30836	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_592873.1	Gene:	tup11 / 2542299	PomBaseID:	SPAC18B11.10	Length:	614	Species:	Schizosaccharomyces pombe

Alignment Length:	291	Identity:	84/291 - (28%)
Similarity:	130/291 - (44%)	Gaps:	39/291 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     7 DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
            ||..:.|       :.::..||:||.|.|.:.|..:.||:.......|.:.||:..:.|:.||.:
pombe   356 DPSRDLY-------VRTIAFSPDGKYLVTGTEDRQIKLWDLSTQKVRYVFSGHEQDIYSLDFSHN 413

Human    72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF 136
            |..:.|.|.|||.|||..:......:.:.... |.::..|.:.||:|..|.|:.|:|||: ....
pombe   414 GRFIVSGSGDRTARLWDVETGQCILKLEIENG-VTAIAISPNDQFIAVGSLDQIIRVWSV-SGTL 476

Human   137 LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCI 201
            :..|..|...|....||||..:::|.|.|||||:|:.       ..:.|||.:   ...|.|.|.
pombe   477 VERLEGHKESVYSIAFSPDSSILLSGSLDKTIKVWEL-------QATRSVGLS---AIKPEGICK 531

Human   202 ASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTL 266
            |:                    |..|:..|..::..|...:.::.|.|.:::..||..|:...|.
pombe   532 AT--------------------YTGHTDFVLSVAVSPDSRWGLSGSKDRSMQFWDLQTGQSYLTC 576

Human   267 QGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
            |||...|.:|.||..|..||||..|.:..:|
pombe   577 QGHKNSVISVCFSPDGRQFASGSGDLRARIW 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POC1B	NP_758440.1	WD40	10..298	CDD:238121	82/288 (28%)
		WD 1	16..55		9/38 (24%)
		WD40 repeat	21..58	CDD:293791	10/36 (28%)
		WD 2	58..99		14/40 (35%)
		WD40 repeat	63..100	CDD:293791	12/36 (33%)
		WD 3	101..139		11/37 (30%)
		WD40 repeat	106..142	CDD:293791	11/35 (31%)
		WD 4	142..181		14/38 (37%)
		WD40 repeat	147..182	CDD:293791	13/34 (38%)
		WD 5	183..223		7/39 (18%)
		WD40 repeat	190..225	CDD:293791	4/34 (12%)
		WD 6	226..265		8/38 (21%)
		WD40 repeat	231..267	CDD:293791	8/35 (23%)
		WD 7	268..307		13/30 (43%)
		WD40 repeat	273..299	CDD:293791	11/25 (44%)
tup11	NP_592873.1	Tup_N	9..86	CDD:285748
		WD40	<303..610	CDD:225201	84/291 (29%)
		WD40	306..608	CDD:238121	84/291 (29%)
		WD40 repeat	316..358	CDD:293791	1/1 (100%)
		WD40 repeat	364..400	CDD:293791	10/35 (29%)
		WD40 repeat	405..441	CDD:293791	12/35 (34%)
		WD40 repeat	447..481	CDD:293791	10/34 (29%)
		WD40 repeat	487..535	CDD:293791	20/77 (26%)
		WD40 repeat	541..577	CDD:293791	8/35 (23%)
		WD40 repeat	583..607	CDD:293791	10/23 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910