DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POC1B and SPAC227.12

DIOPT Version :9

Sequence 1:	NP_758440.1	Gene:	POC1B / 282809	HGNCID:	30836	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_592966.1	Gene:	SPAC227.12 / 2541477	PomBaseID:	SPAC227.12	Length:	462	Species:	Schizosaccharomyces pombe

Alignment Length:	294	Identity:	79/294 - (26%)
Similarity:	133/294 - (45%)	Gaps:	15/294 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP---------H 71
            |.:..|..:..|.||...|:.||...:.:||....:....:.||.|.|:.:.:.|         .
pombe   170 GGERPIAIVRFSNNGNHFASGSWGGQVKVWNSDNLSEVQLFRGHTDRVSGLDWYPLCQAWDADSE 234

Human    72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF 136
            ...||:.:.|.||.||...:.......:.|.|.|..|.|...|.:|.:||.|.:.::|.::....
pombe   235 QLTLATGAADNTVCLWKASQSTPLLRLEGHLARVGRVAFHPSGDYLVSASFDTTWRLWDVHTGVE 299

Human   137 LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCI 201
            |.....|:..:......|||.|:.|...|...:|||..:.:.:....:.:.....:.::|:|..:
pombe   300 LLMQEGHSEGIFSIACQPDGSLVSSGGNDAIGRIWDLRSGKSIMVLDEHIRQIVAMAWSPNGYQL 364

Human   202 ASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG--NYLITASSDGTLKILDLLEGRLIY 264
            |::.:|.|||:||:|...|......||..|:.:.:..||  .::.|:..||.:|:.:.|...||.
pombe   365 ATSSADDTVKIWDLRKVSLAHTIPAHSSLVSDVRYIESGVNRFIATSGYDGCVKLWNPLNCSLIK 429

Human   265 TLQGHTGPVFTVSFSKG-GELFASGGADTQVLLW 297
            ::.||...|.:|.   | |:.|.|.|.|..:.||
pombe   430 SMVGHEEKVMSVD---GYGDRFISSGYDRTIKLW 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POC1B	NP_758440.1	WD40	10..298	CDD:238121	79/294 (27%)
		WD 1	16..55		10/38 (26%)
		WD40 repeat	21..58	CDD:293791	9/36 (25%)
		WD 2	58..99		12/49 (24%)
		WD40 repeat	63..100	CDD:293791	9/45 (20%)
		WD 3	101..139		12/37 (32%)
		WD40 repeat	106..142	CDD:293791	9/35 (26%)
		WD 4	142..181		10/38 (26%)
		WD40 repeat	147..182	CDD:293791	9/34 (26%)
		WD 5	183..223		11/39 (28%)
		WD40 repeat	190..225	CDD:293791	11/34 (32%)
		WD 6	226..265		12/40 (30%)
		WD40 repeat	231..267	CDD:293791	10/37 (27%)
		WD 7	268..307		12/31 (39%)
		WD40 repeat	273..299	CDD:293791	10/26 (38%)
SPAC227.12	NP_592966.1	SFM	48..92	CDD:128776
		WD40	174..460	CDD:238121	76/288 (26%)
		WD40	<178..460	CDD:225201	75/284 (26%)
		WD40 repeat	178..212	CDD:293791	8/33 (24%)
		WD40 repeat	218..263	CDD:293791	8/44 (18%)
		WD40 repeat	268..304	CDD:293791	10/35 (29%)
		WD40 repeat	311..346	CDD:293791	9/34 (26%)
		WD40 repeat	352..384	CDD:293791	10/31 (32%)
		WD40 repeat	394..432	CDD:293791	10/37 (27%)
		WD40 repeat	438..460	CDD:293791	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910