DRSC/TRiP Functional Genomics Resources

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Protein Alignment POC1B and SPBC3D6.12

DIOPT Version :9

Sequence 1:NP_758440.1 Gene:POC1B / 282809 HGNCID:30836 Length:478 Species:Homo sapiens
Sequence 2:NP_595524.1 Gene:SPBC3D6.12 / 2540971 PomBaseID:SPBC3D6.12 Length:922 Species:Schizosaccharomyces pombe


Alignment Length:575 Identity:128/575 - (22%)
Similarity:192/575 - (33%) Gaps:191/575 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     3 SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHA---------------- 51
            ||.|.|       ||:|.:.:|.||.|...:.:.: :..|.|||.|..:                
pombe   388 SAIEIP-------GHRADVRTLALSANHDVILSGA-NGSLKLWNKKTTSCIRTIECGYVLAASFI 444

Human    52 -------RAY-----------------RYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW----- 87
                   .||                 |...|...:..:.....|...|:||.|.||:||     
pombe   445 NNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWSLKSS 509

Human    88 ---IPDKRGKFSEFKAH-------TAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYR 142
               :|....|.:..|..       |..|.:|..|.||:|:|.:..|.::||:.:...:|..:||.
pombe   510 FDFVPGTTRKVTTLKLEQTRQIDFTDDVLAVKISPDGRFVAASLLDNTVKVYYLDSLKFFLNLYG 574

Human   143 HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSD 207
            |...|.....|.|.:|:|:||.||.:|||.                   :||   |.|       
pombe   575 HKLPVLSMDISYDSKLLVTCSADKNVKIWG-------------------LDF---GDC------- 610

Human   208 QTVKVWDVRVNKLLQHYQV--HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGH- 269
                           |..:  |...:..::|.|......|.|.|..::..|.....||..|:|| 
pombe   611 ---------------HKSIFAHQDSIMEVTFQPDTYNFFTCSKDREVRYWDGKSFDLILKLRGHH 660

Human   270 -------TGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLD 327
                   .||.|.|          ||..|..:.||....|.:..:...:|.|:. .::|.  |:.
pombe   661 SEVWALAVGPTFVV----------SGSHDHSIRLWEQGDDLVFLEEERERELEE-QYEST--LVS 712

Human   328 IYPRTPHPHEEK-----------VETVEINPK-LEVI-----DLQISTPPVMDILSFDSTTTTET 375
            .|.......|.|           :|:::...| ||.|     ||.......:|:|        ::
pombe   713 SYENAEADGEVKDGDVAAVTKQTIESLKDGEKILEAITIGIEDLDQEIQYRLDLL--------KS 769

Human   376 SGRT-------LPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSD----LPCE---------- 419
            .|:.       |...|..|..|.||          |..|.::..:.|    ||.|          
pombe   770 PGKARGPRNPILAHLGVSAEEYVLN----------TFKKIRSSHLDDALLVLPFEHVLSLFRFID 824

Human   420 ---SQR-SIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKL 470
               |:: ||||........:......||.||. :...|......|:..|:.::.|
pombe   825 IWASRKWSIPLVSRIIFFLLRTYHRQLTTTVK-MRPLLNNIRSSLRGSLQEERSL 878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POC1BNP_758440.1 WD40 10..298 CDD:238121 80/352 (23%)
WD 1 16..55 14/78 (18%)
WD40 repeat 21..58 CDD:293791 12/76 (16%)
WD 2 58..99 12/48 (25%)
WD40 repeat 63..100 CDD:293791 11/44 (25%)
WD 3 101..139 12/44 (27%)
WD40 repeat 106..142 CDD:293791 11/35 (31%)
WD 4 142..181 13/38 (34%)
WD40 repeat 147..182 CDD:293791 12/34 (35%)
WD 5 183..223 4/39 (10%)
WD40 repeat 190..225 CDD:293791 5/34 (15%)
WD 6 226..265 9/40 (23%)
WD40 repeat 231..267 CDD:293791 8/35 (23%)
WD 7 268..307 12/46 (26%)
WD40 repeat 273..299 CDD:293791 7/25 (28%)
SPBC3D6.12NP_595524.1 WD40 45..368 CDD:238121
WD40 repeat 70..102 CDD:293791
WD40 repeat 107..156 CDD:293791
WD40 152..656 CDD:225201 73/319 (23%)
WD40 repeat 177..212 CDD:293791
WD40 repeat 218..266 CDD:293791
WD40 repeat 274..324 CDD:293791
WD40 repeat 342..394 CDD:293791 4/12 (33%)
WD40 391..686 CDD:238121 82/356 (23%)
WD40 repeat 400..434 CDD:293791 9/34 (26%)
WD40 repeat 438..474 CDD:293791 3/35 (9%)
WD40 repeat 481..532 CDD:293791 12/50 (24%)
WD40 repeat 537..573 CDD:293791 11/35 (31%)
WD40 repeat 579..614 CDD:293791 17/78 (22%)
WD40 repeat 621..645 CDD:293791 5/23 (22%)
WD40 repeat 663..685 CDD:293791 7/31 (23%)
Utp12 789..889 CDD:281932 22/101 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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