DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POC1B and Y41C4A.32

DIOPT Version :9

Sequence 1:	NP_758440.1	Gene:	POC1B / 282809	HGNCID:	30836	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_499518.2	Gene:	Y41C4A.32 / 189814	WormBaseID:	WBGene00270321	Length:	291	Species:	Caenorhabditis elegans

Alignment Length:	299	Identity:	70/299 - (23%)
Similarity:	127/299 - (42%)	Gaps:	33/299 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNF------------KPHARAYRYVGHKDVVTSV 66
            |..|...:.|:|.......:.||.....:.:||:            :...||.:::..|
Worm     8 FVSHSDRVKSVDFHSEKPWILTALHTGNVQIWNYDTKTLVKAMEVSEKSTRAAKFIHRK------ 66

Human    67 QFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
                  |.:|:||.|:.:|::..:.....:||.||:..:||:.......:|.:||:|:.|:||..
Worm    67 ------NWIATASDDQQIRIFDAETFSLINEFTAHSDFIRSLTVHPTLPYLISASDDRKIRVWDW 125

Human   132 YRQ-RFLYSLYRHTHWVRCAKFSP-DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDF 194
            ..: |.......|.|::.....:| |..:.||.|.|||:|:|....::.:..........|.|:|
Worm   126 ENEWRMEQEFQEHAHYIMQIAVNPEDPEMFVSGSLDKTLKVWKLGEQESICTLEGHEKGVNCVEF 190

Human   195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ-VHSGGVNCISFHPSGNYLITASSDGTLKILDLL 258
            ...|. |.|...|.::.|||::..|.::..: .|...|..::  |...::|:.:.|.|:||.:..
Worm   191 LTGGR-IVSGSDDCSICVWDIQTQKCIETLKNAHKNNVTFVT--PFKTWIISGAEDSTVKIWNSQ 252

Human   259 EGRLIYTLQGHTGPVFTVSFSKGGEL---FASGGADTQV 294
            ...|...|....|..:.|:..|...:   |.||....::
Worm   253 TFSLEKELNFEKGRAWCVAAGKSDAIAVGFDSGAVTVEI 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POC1B	NP_758440.1	WD40	10..298	CDD:238121	70/299 (23%)
		WD 1	16..55		9/50 (18%)
		WD40 repeat	21..58	CDD:293791	8/48 (17%)
		WD 2	58..99		8/40 (20%)
		WD40 repeat	63..100	CDD:293791	8/36 (22%)
		WD 3	101..139		11/38 (29%)
		WD40 repeat	106..142	CDD:293791	10/36 (28%)
		WD 4	142..181		12/39 (31%)
		WD40 repeat	147..182	CDD:293791	10/35 (29%)
		WD 5	183..223		11/39 (28%)
		WD40 repeat	190..225	CDD:293791	11/34 (32%)
		WD 6	226..265		9/38 (24%)
		WD40 repeat	231..267	CDD:293791	8/35 (23%)
		WD 7	268..307		6/30 (20%)
		WD40 repeat	273..299	CDD:293791	5/25 (20%)
Y41C4A.32	NP_499518.2	WD40	8..271	CDD:238121	65/277 (23%)
		WD40 repeat	17..52	CDD:293791	6/34 (18%)
		WD40 repeat	58..94	CDD:293791	11/47 (23%)
		WD40 repeat	99..136	CDD:293791	10/36 (28%)
		WD40 repeat	143..179	CDD:293791	10/35 (29%)
		WD40 repeat	185..220	CDD:293791	11/35 (31%)
		WD40 repeat	224..251	CDD:293791	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910