DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POC1B and wdr-5.3

DIOPT Version :9

Sequence 1:	NP_758440.1	Gene:	POC1B / 282809	HGNCID:	30836	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_001024299.1	Gene:	wdr-5.3 / 179489	WormBaseID:	WBGene00013862	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	297	Identity:	76/297 - (25%)
Similarity:	136/297 - (45%)	Gaps:	6/297 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
            |.:...||..:::.:..|..||.|.|.|.|..:.:||............|:..:....:|.:...
Worm   205 LVKTISGHTKSVSVIKFSYCGKYLGTGSADKQIKVWNTVDMTYLQTLASHQLGINDFSWSSNSQF 269

Human    75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139
            :||||.|.||:::...........:.||..|....|:.....:|:|..|::::||.......:..
Worm   270 IASASDDTTVKIFDVISGACLRTMRGHTNYVFCCSFNPQSSLIASAGFDETVRVWDFKTGLCVKC 334

Human   140 LYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDS-VGFANFVDFNPSGTCIAS 203
            :..|:..:....::.||..:.:.|.|..|::||..:..|:....|: .....||.|:|:|..:.|
Worm   335 IPAHSDPITSISYNHDGNTMATSSYDGCIRVWDAASGSCLKTLVDTDHAPVTFVCFSPNGKYLLS 399

Human   204 AGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH---PSGNYLITASSDGTLKILDLLEGRLIYT 265
            |..|.::|:||.:..|.|::|..|.....|:..:   |.|.::|:.|.||.:.:..:...:::..
Worm   400 AQLDSSLKLWDPKKAKPLKYYNGHKNKKYCLFANMSVPLGKHIISGSEDGRILVWSIQTKQIVQI 464

Human   266 LQGHTGPVFTVSFSKGGELFASGG--ADTQVLLWRTN 300
            |:|||.||..........:.||||  .|..:.:||.|
Worm   465 LEGHTTPVLATDSHPTLNIIASGGLEPDNVIRIWRRN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POC1B	NP_758440.1	WD40	10..298	CDD:238121	73/293 (25%)
		WD 1	16..55		11/38 (29%)
		WD40 repeat	21..58	CDD:293791	9/36 (25%)
		WD 2	58..99		9/40 (23%)
		WD40 repeat	63..100	CDD:293791	8/36 (22%)
		WD 3	101..139		9/37 (24%)
		WD40 repeat	106..142	CDD:293791	6/35 (17%)
		WD 4	142..181		9/38 (24%)
		WD40 repeat	147..182	CDD:293791	8/34 (24%)
		WD 5	183..223		14/40 (35%)
		WD40 repeat	190..225	CDD:293791	13/34 (38%)
		WD 6	226..265		8/41 (20%)
		WD40 repeat	231..267	CDD:293791	7/38 (18%)
		WD 7	268..307		13/35 (37%)
		WD40 repeat	273..299	CDD:293791	7/27 (26%)
wdr-5.3	NP_001024299.1	WD40	<200..501	CDD:225201	75/295 (25%)
		WD40	205..499	CDD:238121	73/293 (25%)
		WD40 repeat	216..253	CDD:293791	9/36 (25%)
		WD40 repeat	259..295	CDD:293791	8/35 (23%)
		WD40 repeat	300..336	CDD:293791	7/35 (20%)
		WD40 repeat	343..378	CDD:293791	8/34 (24%)
		WD40 repeat	385..421	CDD:293791	13/35 (37%)
		WD40 repeat	429..466	CDD:293791	7/36 (19%)
		WD40 repeat	472..498	CDD:293791	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161450765
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840