Protein Alignment POC1B and wdr-5.1

DIOPT Version :10

• Sequence 1: NP_758440.1
• Gene: POC1B / 282809
• HGNCID: 30836
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_497749.1
• Gene: wdr-5.1 / 175474
• WormBaseID: WBGene00006474
• Length: 376
• Species: Caenorhabditis elegans
• Alignment Length: 310
• Identity: 92/310 - (29%)
• Similarity: 148/310 - (47%)
• Gaps: 16/310 - (5%)

Human     2 ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
            ||.:.:..|....:||..:|:|...||.||.|.|:|.|..:.:||...........|||..|..:
 Worm    71 ASGSANYKLMCTLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDI 135

Human    67 QFSPHGNLLASASRDRTVRLW--IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
            .:|.....:.|||.|:|::::  :..:..|  ..|.|...|...:|:.....:.:.|.|:|:::|
 Worm   136 AWSSDSRCVVSASDDKTLKIFEIVTSRMTK--TLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIW 198

Human   130 SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN---- 190
            .:.....:.:|..|:..|....|:.||.||.|.|.|..::||||.|.||:....|.   .|
 Worm   199 DVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIKTLVDD---ENPPVA 260

Human   191 FVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGTL 252
            ||.|:|:|..|.::..|.|:|:||....|.|:.|..|.....||..:.|   |.::|:.|.|..:
 Worm   261 FVKFSPNGKYILASNLDSTLKLWDFSKGKTLKQYTGHENSKYCIFANFSVTGGKWIISGSEDCKI 325

Human   253 KILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG--ADTQVLLWRTN 300
            .|.:|....::..|:|||.||..........:.|||.  .|.::.:||::
 Worm   326 YIWNLQTREIVQCLEGHTQPVLASDCHPVQNIIASGALEPDNKIHIWRSD 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POC1B	NP_758440.1	WD40	<5..300	CDD:441893	90/305 (30%)
		WD 1	16..55		14/38 (37%)
		WD40 repeat	21..58	CDD:293791	12/36 (33%)
		WD 2	58..99		11/42 (26%)
		WD40 repeat	63..100	CDD:293791	8/38 (21%)
		WD 3	101..139		7/37 (19%)
		WD40 repeat	106..142	CDD:293791	6/35 (17%)
		WD 4	142..181		17/38 (45%)
		WD40 repeat	147..182	CDD:293791	16/34 (47%)
		WD 5	183..223		15/43 (35%)
		WD40 repeat	190..225	CDD:293791	14/38 (37%)
		WD 6	226..265		10/41 (24%)
		WD40 repeat	231..267	CDD:293791	9/38 (24%)
		WD 7	268..307		11/35 (31%)
		WD40 repeat	273..299	CDD:293791	6/27 (22%)
wdr-5.1	NP_497749.1	PRK13914	<2..>96	CDD:237555	7/24 (29%)
		WD40	79..373	CDD:238121	88/298 (30%)
		WD40 repeat	90..127	CDD:293791	12/36 (33%)
		WD40 repeat	133..169	CDD:293791	7/37 (19%)
		WD40 repeat	174..210	CDD:293791	6/35 (17%)
		WD40 repeat	217..252	CDD:293791	15/34 (44%)
		WD40 repeat	259..295	CDD:293791	13/35 (37%)
		WD40 repeat	303..340	CDD:293791	9/36 (25%)
		WD40 repeat	346..372	CDD:293791	5/25 (20%)