DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POC1B and wdr-5.1

DIOPT Version :9

Sequence 1:	NP_758440.1	Gene:	POC1B / 282809	HGNCID:	30836	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_497749.1	Gene:	wdr-5.1 / 175474	WormBaseID:	WBGene00006474	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	310	Identity:	92/310 - (29%)
Similarity:	148/310 - (47%)	Gaps:	16/310 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     2 ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
            ||.:.:..|....:||..:|:|...||.||.|.|:|.|..:.:||...........|||..|..:
Worm    71 ASGSANYKLMCTLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDI 135

Human    67 QFSPHGNLLASASRDRTVRLW--IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
            .:|.....:.|||.|:|::::  :..:..|  ..|.|...|...:|:.....:.:.|.|:|:::|
Worm   136 AWSSDSRCVVSASDDKTLKIFEIVTSRMTK--TLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIW 198

Human   130 SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN---- 190
            .:.....:.:|..|:..|....|:.||.||.|.|.|..::||||.|.||:....|.   .|
Worm   199 DVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIKTLVDD---ENPPVA 260

Human   191 FVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGTL 252
            ||.|:|:|..|.::..|.|:|:||....|.|:.|..|.....||..:.|   |.::|:.|.|..:
Worm   261 FVKFSPNGKYILASNLDSTLKLWDFSKGKTLKQYTGHENSKYCIFANFSVTGGKWIISGSEDCKI 325

Human   253 KILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG--ADTQVLLWRTN 300
            .|.:|....::..|:|||.||..........:.|||.  .|.::.:||::
Worm   326 YIWNLQTREIVQCLEGHTQPVLASDCHPVQNIIASGALEPDNKIHIWRSD 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POC1B	NP_758440.1	WD40	10..298	CDD:238121	88/298 (30%)
		WD 1	16..55		14/38 (37%)
		WD40 repeat	21..58	CDD:293791	12/36 (33%)
		WD 2	58..99		11/42 (26%)
		WD40 repeat	63..100	CDD:293791	8/38 (21%)
		WD 3	101..139		7/37 (19%)
		WD40 repeat	106..142	CDD:293791	6/35 (17%)
		WD 4	142..181		17/38 (45%)
		WD40 repeat	147..182	CDD:293791	16/34 (47%)
		WD 5	183..223		15/43 (35%)
		WD40 repeat	190..225	CDD:293791	14/38 (37%)
		WD 6	226..265		10/41 (24%)
		WD40 repeat	231..267	CDD:293791	9/38 (24%)
		WD 7	268..307		11/35 (31%)
		WD40 repeat	273..299	CDD:293791	6/27 (22%)
wdr-5.1	NP_497749.1	WD40	<76..372	CDD:225201	88/300 (29%)
		WD40	79..373	CDD:238121	88/298 (30%)
		WD40 repeat	90..127	CDD:293791	12/36 (33%)
		WD40 repeat	133..169	CDD:293791	7/37 (19%)
		WD40 repeat	174..210	CDD:293791	6/35 (17%)
		WD40 repeat	217..252	CDD:293791	15/34 (44%)
		WD40 repeat	259..295	CDD:293791	13/35 (37%)
		WD40 repeat	303..340	CDD:293791	9/36 (25%)
		WD40 repeat	346..372	CDD:293791	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161450764
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840