DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR4 and TkR86C

DIOPT Version :9

Sequence 1:	NP_005273.1	Gene:	GPR4 / 2828	HGNCID:	4497	Length:	362	Species:	Homo sapiens
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	398	Identity:	92/398 - (23%)
Similarity:	158/398 - (39%)	Gaps:	96/398 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    12 DSRVDHLFP------------PSLYIFVIG----VGLPTNCLALWAAYRQVQQRNELGVYLMNLS 60
            |...:.|||            .:::..:.|    |.:..|.:.||........|.....:|:|||
  Fly    62 DFLTECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLS 126

Human    61 IADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRF 125
            |||||......::...|:.:.:|..|...|.:..|:....:..|:..|..||.|||:|:.|||:.
  Fly   127 IADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKR 191

Human   126 ARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRY----NHTFCFEKFPMEGWVAWM----- 181
            ...||....:.|  ::||.....::..|.:..:....|    :.|.||..:|...:...|
  Fly   192 RTSRRKVRIILV--LIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAY 254

Human   182 NLYRVFVGFLFPWALMLLSYRGILRAVRGSVS----TERQ-----EKAKIKRLALSLIAIVLVCF 237
            ||..:.:.:..|..:||:.|..:.|.:.||.|    |:||     .|.|:.|:.:::::|..:|:
  Fly   255 NLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICW 319

Human   238 APYHVLLLSR------------SAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVN 290
            .|||:..:..            ..:|||..|               ||.:  |.:.:|::|..:|
  Fly   320 LPYHLFFIYAYHNNQVASTKYVQHMYLGFYW---------------LAMS--NAMVNPLIYYWMN 367

Human   291 EGARSDVAKAL---------HNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAA-- 344
            :..|....:.:         |   ||   |.|          ::.||:|.:|......|...|
  Fly   368 KRFRMYFQRIICCCCVGLTRH---RF---DSP----------KSRLTNKNSSNRHTRGGYTVAHS 416

Human   345 ----TPPS 348
                :||:
  Fly   417 LPNSSPPT 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR4	NP_005273.1	7tmA_GPR4	18..297	CDD:320488	78/324 (24%)
		TM helix 1	20..44	CDD:320488	6/39 (15%)
		TM helix 2	53..74	CDD:320488	9/20 (45%)
		TM helix 3	91..113	CDD:320488	4/21 (19%)
		TM helix 4	136..152	CDD:320488	3/15 (20%)
		TM helix 5	179..202	CDD:320488	6/27 (22%)
		TM helix 6	223..245	CDD:320488	6/21 (29%)
		TM helix 7	265..290	CDD:320488	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..362		4/20 (20%)
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	74/302 (25%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	70/281 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910