DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR4 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_005273.1	Gene:	GPR4 / 2828	HGNCID:	4497	Length:	362	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	103/378 - (27%)
Similarity:	169/378 - (44%)	Gaps:	66/378 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     5 TWEGCHV--DSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYI 67
            |::.|..  :|..| ||...||.||..:||..|.|.::...|..:.:....:|::||::||..::
  Fly    64 TYQHCIATRNSFAD-LFTVVLYGFVCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVADECFL 127

Human    68 CTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNI--YISIAFLCCISVDRYLAVAHPLRFARLRR 130
            ..:|..: |.:...:|..|...||  .::..|:|  :.|..||..:|.|||:||.||:...|.|.
  Fly   128 IGIPFLL-YTMRICSWRFGEFMCK--AYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRT 189

Human   131 VKTAVAVSSVVWAT-----------------ELGAN-SAPLFHDELFRDRYNHTFCFEKFPMEGW 177
            :..|..||::.|:|                 |.|.| |..:...:.::.....||.
  Fly   190 LHIAKVVSAIAWSTSAVLMLPVILYASTVEQEDGINYSCNIMWPDAYKKHSGTTFI--------- 245

Human   178 VAWMNLYRVFVGFLFPWALMLLSYRGILRAVR------GSVSTE-RQEKAKIKRLALSLIAIVLV 235
                 ||..|:||..|...:|..|..::|.:|      |:.|.| |:...|:.||.|::|::.::
  Fly   246 -----LYTFFLGFATPLCFILSFYYLVIRKLRSVGPKPGTKSKEKRRAHRKVTRLVLTVISVYIL 305

Human   236 CFAPYHVLLLSRSAIYLGRP--WDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVA 298
            |:.|:.:   |:.|:....|  .|....|.:......:|.::  |...:||||..::|..|....
  Fly   306 CWLPHWI---SQVALIHSNPAQRDLSRLEILIFLLLGALVYS--NSAVNPILYAFLSENFRKSFF 365

Human   299 KALHNLLRFLASDKPQEMANASLTLE----TPLTSKRNSTAKAMTGSWAATPP 347
            ||      |...:| |:: ||.|.||    |...||:...:|.:..|....||
  Fly   366 KA------FTCMNK-QDI-NAQLQLEPSVFTKQGSKKRGGSKRLLTSNPQIPP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR4	NP_005273.1	7tmA_GPR4	18..297	CDD:320488	82/307 (27%)
		TM helix 1	20..44	CDD:320488	8/23 (35%)
		TM helix 2	53..74	CDD:320488	6/20 (30%)
		TM helix 3	91..113	CDD:320488	6/23 (26%)
		TM helix 4	136..152	CDD:320488	8/33 (24%)
		TM helix 5	179..202	CDD:320488	7/22 (32%)
		TM helix 6	223..245	CDD:320488	6/21 (29%)
		TM helix 7	265..290	CDD:320488	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..362		4/13 (31%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	78/307 (25%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	70/280 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910