DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR3 and gpr186

DIOPT Version :9

Sequence 1:	NP_005272.1	Gene:	GPR3 / 2827	HGNCID:	4484	Length:	330	Species:	Homo sapiens
Sequence 2:	NP_001076384.1	Gene:	gpr186 / 796164	ZFINID:	ZDB-GENE-060503-489	Length:	326	Species:	Danio rerio

Alignment Length:	326	Identity:	157/326 - (48%)
Similarity:	212/326 - (65%)	Gaps:	18/326 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    20 NVSSVG--------------PAEGPTGP-AAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTP 69
            |.|.||              |::.|..| .|.:.:|  ||:.||:||.|:.||||:|||.|..:.
Zfish     4 NSSEVGLEVILAMNQLLDLPPSQMPPKPLEASVMTP--WDITLCVSGVLICCENAIVVATIFSSS 66

Human    70 AFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDR 134
            :.|||||||:||||.||.|||:||:|||.:..|:.|..:.|..||:|..|.:||:.|||.||:||
Zfish    67 SLRAPMFLLIGSLAWADFLAGVGLLLHFLSRRCVYSEALELGSVGLLVSALSASVFSLLGITLDR 131

Human   135 YLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLA 199
            :|||::||||.|:.|.|:|...||:.|..|...|.||.|.||||....:|.|:.||::.||..|.
Zfish   132 FLSLHHALTYGSQRTHTQTRCALAVGWTLAGLQGALPALGWNCLHDGDSCSVLRPLTRVHLATLC 196

Human   200 IAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFT 264
            ..|.:...::|||.|:|||:|.||:.|||||||.||::. ..||:.:.|||::|..||:||:||.
Zfish   197 GGFLLTLALLLQLNARICRVVLRHSHQIALQRHTLPSAR-THTRRRVHTLALILATFASCWIPFA 260

Human   265 VYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSD 329
            :|.||||..||.||||.||:|.|.||::||:|||:||..:|:||....|||..:.....:.:|||
Zfish   261 LYGLLGDGSSPALYTYATLVPVTGNSLLNPLIYAYRNTHIQRVLRQTVCCCLPNTPNKNTHTPSD 325

Human   330 V 330
            |
Zfish   326 V 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR3	NP_005272.1	7tm_GPCRs	41..308	CDD:391938	139/266 (52%)
		TM helix 1	43..67	CDD:341315	15/23 (65%)
		TM helix 2	76..97	CDD:341315	15/20 (75%)
		TM helix 3	110..132	CDD:341315	11/21 (52%)
		TM helix 4	155..171	CDD:341315	5/15 (33%)
		TM helix 5	191..214	CDD:341315	7/22 (32%)
		TM helix 6	243..268	CDD:341315	12/24 (50%)
		TM helix 7	276..301	CDD:341315	15/24 (63%)
gpr186	NP_001076384.1	7tm_1	54..293	CDD:278431	125/239 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341968
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386328at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.810